KEGG   ENZYME: 2.4.2.12Help
Entry
EC 2.4.2.12                 Enzyme                                 

Name
nicotinamide phosphoribosyltransferase;
NMN pyrophosphorylase;
nicotinamide mononucleotide pyrophosphorylase;
nicotinamide mononucleotide synthetase;
NMN synthetase;
nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
nicotinamide-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase
Reaction(IUBMB)
nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01271]
Reaction(KEGG)
Substrate
nicotinamide D-ribonucleotide [CPD:C00455];
diphosphate [CPD:C00013]
Product
nicotinamide [CPD:C00153];
5-phospho-alpha-D-ribose 1-diphosphate [CPD:C00119]
History
EC 2.4.2.12 created 1961
Pathway
Nicotinate and nicotinamide metabolism
Orthology
K03462  
nicotinamide phosphoribosyltransferase
Genes
HSA: 
10135(NAMPT)
PTR: 
463648(NAMPT) 741031
PPS: 
GGO: 
101151211(NAMPT)
PON: 
100453575(NAMPT)
MCC: 
698609(NAMPT)
MCF: 
102144763(NAMPT)
MMU: 
59027(Nampt)
RNO: 
297508(Nampt)
CGE: 
HGL: 
101708723(Nampt)
TUP: 
CFA: 
100856598(NAMPT)
AML: 
FCA: 
101081370(NAMPT)
BTA: 
520472(NAMPT)
BOM: 
102277699(NAMPT)
PHD: 
102326145(NAMPT)
CHX: 
102173810(NAMPT)
SSC: 
595123(NAMPT)
CFR: 
102519471(NAMPT)
ECB: 
100059684(NAMPT)
MYB: 
102242336(NAMPT)
MDO: 
SHR: 
100925196(NAMPT)
OAA: 
GGA: 
417707(NAMPT)
MGP: 
TGU: 
100223583(NAMPT)
FAB: 
101808963(NAMPT)
PHI: 
102107305(NAMPT)
APLA: 
101800925(NAMPT)
FPG: 
101920910(NAMPT)
FCH: 
102047445(NAMPT)
CLV: 
102094757(NAMPT)
ASN: 
102386190(NAMPT)
PSS: 
102458338(NAMPT)
ACS: 
XLA: 
398502(nampt) 735059
XTR: 
496856(nampt)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352973(NAMPT)
BFO: 
SPU: 
ISC: 
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
TAD: 
AQU: 
MBR: 
CFF: 
SYN: 
CPI: 
NKO: 
SCN: 
MTT: 
DRA: 
MST: 
MSI: 
MEB: 
 » show all
Taxonomy
Reference
1  [PMID:13416279]
  Authors
PREISS J, HANDLER P.
  Title
Enzymatic synthesis of nicotinamide mononucleotide.
  Journal
J. Biol. Chem. 225 (1957) 759-70.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-27-7

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