| Entry |
|
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| Name |
pyrimidine-nucleoside phosphorylase;
Py-NPase |
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| Class |
Transferases;
Glycosyltransferases;
Pentosyltransferases
 |
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| Sysname |
pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase |
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| Reaction(IUBMB) |
a pyrimidine nucleoside + phosphate = a pyrimidine base +
alpha-D-ribose 1-phosphate [RN:R02298] |
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| Reaction(KEGG) |
R02298 > R02296
 |
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| Substrate |
pyrimidine nucleoside [CPD:C03169];
phosphate [CPD:C00009] |
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| Product |
pyrimidine base [CPD:C00396];
alpha-D-ribose 1-phosphate [CPD:C00620] |
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| Comment |
Both uridine and thymidine are substrates [3]. |
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| Pathway |
PATH: ec00240 Pyrimidine metabolism
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00756 pyrimidine-nucleoside phosphorylase |
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| Genes |
BBA: Bd3855(pdp)
ACP: A2cp1_0651
AFW: Anae109_0662
ANK: AnaeK_0651
MXA: MXAN_5710(pdp)
SCL: sce2436(pdp)
HOH: Hoch_6093
BSU: BSU39400(pdp)
BHA: BH1533(pdp)
BAN: BA1894(pyn-1) BA4307(pyn-2)
BAR: GBAA1894(pyn-1) GBAA4307(pyn-2)
BAA: BA_4765
BAT: BAS1756 BAS3995
BAH: BAMEG_2698(pyn1) BAMEG_4346(pyn2)
BAI: BAA_1962(pyn1) BAA_4328(pyn2)
BCE: BC1822 BC4085
BCA: BCE_1977(pyn) BCE_4154(pyn)
BCZ: BCZK1705(pyn) BCZK3842(pdp)
BCR: BCAH187_A2004(pyn1) BCAH187_A4218(pyn2)
BCB: BCB4264_A1897(pyn1) BCB4264_A4195(pyn2)
BCU: BCAH820_1929(pyn1) BCAH820_4109(pyn2)
BCG: BCG9842_B1042(pyn2) BCG9842_B3449(pyn1)
BCQ: BCQ_1889(pyn) BCQ_3876(pdp)
BCX: BCA_1962(pyn1) BCA_4197(pyn2)
BCY: Bcer98_2784
BTK: BT9727_1734(pyn) BT9727_3826(pdp)
BTL: BALH_1676 BALH_3703
BWE: BcerKBAB4_1754 BcerKBAB4_3916
BLI: BL00227(pdp)
BLD: BLi04227(pdp)
BCL: ABC1784(pdp)
BAY: RBAM_036460(pdp)
BPU: BPUM_3585(pdp)
OIH: OB1844(pdp)
GKA: GK2312
GTN: GTNG_2243
GWC: GWCH70_2254
GYM: GYMC10_5645
GYC: GYMC61_0370
AFL: Aflv_1000
SAU: SA1938(pdp)
SAV: SAV2136(pdp)
SAW: SAHV_2120(pdp)
SAM: MW2060(pdp)
SAR: SAR2224(pyn)
SAS: SAS2039
SAC: SACOL2128(pdp)
SAB: SAB2020c(pyn)
SAA: SAUSA300_2089(pdp)
SAX: USA300HOU_2125(pdp)
SAO: SAOUHSC_02377
SAJ: SaurJH9_2172
SAH: SaurJH1_2210
SAE: NWMN_2040(pdp)
SAD: SAAV_2191
SEP: SE1735
SER: SERP1744(pdp)
SHA: SH0898(deoA)
SSP: SSP0748
SCA: Sca_2012(pdp)
LMO: lmo1993(pdp)
LMF: LMOf2365_2016(pyn)
LMH: LMHCC_0567
LMC: Lm4b_02005(pdp)
LIN: lin2101
LWE: lwe2013(pdp)
LSP: Bsph_1711
ESI: Exig_1004
EAT: EAT1b_0449
MCL: MCCL_1795(pdp)
BBE: BBR47_23840(pdp)
PJD: Pjdr2_2337
LLA: L64175(pdp)
LLK: LLKF_1548(pdp)
LLC: LACR_1531
LLM: llmg_1060(pdp)
SPN: SP_0842
SPD: SPD_0736(pdp)
SPR: spr0744(pdp)
SPW: SPCG_0784(pdp)
SPX: SPG_0762(pdp)
SNE: SPN23F_07630(deoA)
SPV: SPH_0941
SNM: SP70585_0878
SJJ: SPJ_0779
SPP: SPP_0848
SNT: SPT_1361
SMU: SMU.1124(pdp)
STC: str0801 str0802 str0803 str0804
STL: stu0801 stu0802 stu0803 stu0804
SSA: SSA_1035(pdp)
SSU: SSU05_1086
SSV: SSU98_1097
SSB: SSUBM407_0846(deoA)
SSI: SSU0937(deoA)
SSS: SSUSC84_0978(deoA)
SGO: SGO_1079(pdp)
SEQ: SZO_10270
SEZ: Sez_0933(pdp)
SEU: SEQ_1058
SUB: SUB0953(deoA)
SDS: SDEG_1050(pdp)
LSA: LSA0801(pdp)
LBR: LVIS_1591
LCA: LSEI_2206
LCB: LCABL_23870(pdp)
LRE: Lreu_0113
LRF: LAR_0107
LRH: LGG_02209(pdp)
LRL: LC705_02198(pdp)
EFA: EF0173(pyn)
CAC: CAC1546(deoA)
CPE: CPE1807(deoA)
CPF: CPF_2062(pdp)
CPR: CPR_1776(pdp)
CTC: CTC01993
CNO: NT01CX_1499
CDF: CD1225(deoA)
CDC: CD196_1085(deoA)
CDL: CDR20291_1063(deoA)
CBO: CBO1863(pdp)
CBA: CLB_1799(pdp)
CBH: CLC_1806(pdp)
CBY: CLM_2024(pdp)
CBL: CLK_1249(pdp)
CBK: CLL_A0735
CBB: CLD_2777(pdp)
CBI: CLJ_B2036(pdp)
CBT: CLH_0703
CBF: CLI_1865(pdp)
CKL: CKL_1243(pdp)
CKR: CKR_1140
CPY: Cphy_2591
CCE: Ccel_1750
AMT: Amet_2527
AOE: Clos_1589
STH: STH1039
SWO: Swol_0609
VPR: Vpar_0408
ATE: Athe_1775
DHD: Dhaf_3447
DAE: Dtox_2054
DAU: Daud_1280
HMO: HM1_0316(pdp)
APR: Apre_0039
EEL: EUBELI_01112
CHY: CHY_1554(pdp)
ADG: Adeg_1318
CPO: COPRO5265_0792(pdp)
NTH: Nther_1665
HOR: Hore_06970
MHY: mhp298(deoA)
MCP: MCAP_0757(deoA)
MAT: MARTH_orf238(deoA)
MCO: MCJ_005580(deoA) MCJ_005590(deoA)
MHO: MHO_3340(deoA)
UPA: UPA3_0384(pdp)
UUE: UUR10_0377(pdp)
ACL: ACL_0683(deoA)
MSM: MSMEG_1675(deoA)
APV: Apar_0147
TDE: TDE2191(pdp)
SRU: SRU_1163(pyn)
RMR: Rmar_0075
CPI: Cpin_2563
LBA: Lebu_0788
STR: Sterm_1789
SMF: Smon_0508
OTE: Oter_1625
GAU: GAU_0793(pdp)
RBA: RB10231(pyn)
TAI: Taci_1021
CTS: Ctha_0612
CAG: Cagg_3238
CHL: Chy400_0507
HAU: Haur_4182
DRA: DR_0443
DDR: Deide_01070
TMA: TM1653
TLE: Tlet_0988
TRQ: TRQ2_1176
TNA: CTN_0734
TNP: Tnap_1153
TME: Tmel_1840
TAF: THA_136
FNO: Fnod_1488
PMO: Pmob_0877
KOL: Kole_1573
DTH: DICTH_1361
DTU: Dtur_1471
 |
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| Structures |
PDB: 1BRW 2DSJ 3H5Q |
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Reference
Authors
Title
Journal
|
1
Friedkin, M. and Kalckar, H.
Nucleoside phosphorylases.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 5, Academic Press, New York, 1961, p. 237-255. |
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Reference
Authors
Title
Journal
Organism
|
2 [PMID:4978445]
Saunders PP, Wilson BA, Saunders GF.
Purification and comparative properties of a pyrimidine nucleoside
phosphorylase from Bacillus stearothermophilus.
J. Biol. Chem. 244 (1969) 3691-7.
Bacillus stearothermophilus |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:8782414]
Hamamoto T, Noguchi T, Midorikawa Y.
Purification and characterization of purine nucleoside phosphorylase
and pyrimidine nucleoside phosphorylase from Bacillus
stearothermophilus TH 6-2.
Biosci. Biotechnol. Biochem. 60 (1996) 1179-80.
Bacillus stearothermophilus |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.2.2
IUBMB Enzyme Nomenclature: 2.4.2.2
ExPASy - ENZYME nomenclature database: 2.4.2.2
BRENDA, the Enzyme Database: 2.4.2.2
CAS: 9055-35-0 |
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