| Entry |
|
|---|
| Name |
nicotinate-nucleotide---dimethylbenzimidazole
phosphoribosyltransferase;
nicotinate mononucleotide-dimethylbenzimidazole
phosphoribosyltransferase;
nicotinate ribonucleotide:benzimidazole (adenine)
phosphoribosyltransferase;
nicotinate-nucleotide:dimethylbenzimidazole
phospho-D-ribosyltransferase;
CobT;
nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole
phosphoribosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Pentosyltransferases
 |
|---|
| Sysname |
nicotinate-nucleotide:5,6-dimethylbenzimidazole
phospho-D-ribosyltransferase |
|---|
| Reaction(IUBMB) |
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole =
nicotinate + alpha-ribazole 5'-phosphate [RN:R04148] |
|---|
| Reaction(KEGG) |
R04148
 |
|---|
| Substrate |
beta-nicotinate D-ribonucleotide [CPD:C01185];
5,6-dimethylbenzimidazole [CPD:C03114] |
|---|
| Product |
nicotinate [CPD:C00253];
alpha-ribazole 5'-phosphate [CPD:C04778] |
|---|
| Comment |
Also acts on benzimidazole, and the clostridial enzyme acts on
adenine to form 7-alpha-D-ribosyladenine 5'-phosphate. The product
of the reaction, alpha-ribazole 5'-phosphate, forms part of the
corrin-biosynthesis pathway and is a substrate for EC 2.7.8.26,
adenosylcobinamide-GDP ribazoletransferase [4]. It can also be
dephosphorylated to form alpha-ribazole by the action of EC
3.1.3.73, alpha-ribazole phosphatase. |
|---|
| Pathway |
PATH: ec00740 Riboflavin metabolism
PATH: ec00860 Porphyrin and chlorophyll metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00768 nicotinate-nucleotide--dimethylbenzimidazole
phosphoribosyltransferase |
|---|
| Genes |
ECO: b1991(cobT)
ECJ: JW1969(cobT)
ECD: ECDH10B_2135(cobT)
EBW: BWG_1785(cobT)
ECE: Z3151(cobT)
ECS: ECs2786(cobT)
ECF: ECH74115_2836(cobT)
ETW: ECSP_2656(cobT)
ECG: E2348C_2124(cobT)
ECC: c2477(cobT)
ECI: UTI89_C2229(cobT)
ECP: ECP_1989(cobT)
ECV: APECO1_1072(cobT)
ECW: EcE24377A_2273(cobT)
ECX: EcHS_A2114(cobT)
ECM: EcSMS35_1133(cobT)
ECY: ECSE_2275(cobT)
ECL: EcolC_1637(cobT)
ECK: EC55989_2225(cobT)
ECQ: ECED1_2327(cobT)
ECR: ECIAI1_2072(cobT)
ECT: ECIAI39_1056(cobT)
ECZ: ECS88_2056(cobT)
EUM: ECUMN_2327(cobT)
ELF: LF82_0336(cobT)
EBL: B21_01889(cobT)
EBD: ECBD_1658
EBR: ECB_01900(cobT)
EOH: ECO103_2452(cobT)
EOI: ECO111_2637(cobT)
EOJ: ECO26_2881(cobT)
STY: STY2219(cobT)
STT: t0858(cobT)
SPT: SPA0855(cobT)
SEK: SSPA0800(cobT)
SPQ: SPAB_01089(cobT)
SEI: SPC_1699(cobT)
SEC: SC2024(cobT)
SEH: SeHA_C2238(cobT)
SEE: SNSL254_A2192(cobT)
SEW: SeSA_A2185(cobT)
SEA: SeAg_B2138(cobT)
SED: SeD_A2351(cobT)
SEG: SG2040(cobT)
SET: SEN2014(cobT)
SES: SARI_00872(cobT)
STM: STM2016(cobT)
YEN: YE2707(cobT)
SFL: SF2059(cobT)
SFX: S2169(cobT)
SFV: SFV_2063(cobT)
SSN: SSON_2052(cobT)
SBO: SBO_1212(cobT)
SBC: SbBS512_E0967(cobT)
SDY: SDY_2242(cobT)
PLU: plu2980(cobT)
PAY: PAU_01618(cobT)
KPN: KPN_02463(cobT) KPN_03182(cobT)
KPE: KPK_0934(cobT) KPK_1724(cobT)
KPU: KP1_3667(cobT) KP1_4446(cobT)
CKO: CKO_00822(cobT)
EIC: NT01EI_1851
ETR: ETAE_1847(cobT)
XCC: XCC3059(cobT)
XCB: XC_1099(cobT)
XCA: xccb100_1136(cobT)
XCV: XCV3315(cobT)
XAC: XAC3186(cobT)
XOO: XOO1351(cobT)
XOM: XOO_1241(cobT)
XOP: PXO_01924(cobT)
VCH: VC1237(cobT)
VCO: VC0395_A0859(cobT)
VCM: VCM66_1192(cobT)
VCJ: VCD_003111
VVU: VV1_2788(cobT)
VVY: VV1474(cobT)
VPA: VP1304(cobT)
VHA: VIBHAR_02126(cobT)
VSP: VS_1702(cobT)
VEX: VEA_003693
PPR: PBPRA1182(cobT)
PAE: PA1279(cobT)
PAU: PA14_47670(cobT)
PAP: PSPA7_4111(cobT)
PAG: PLES_40331(cobT)
PPU: PP_1679(cobT)
PPF: Pput_4040(cobT)
PPG: PputGB1_1278(cobT)
PPW: PputW619_1238(cobT)
PST: PSPTO_1715(cobT)
PSB: Psyr_3674(cobT)
PSP: PSPPH_3695(cobT)
PFL: PFL_4424(cobT)
PFO: Pfl01_1648(cobT)
PFS: PFLU4483
PEN: PSEEN1385(cobT)
PMY: Pmen_1757(cobT)
PSA: PST_1299(cobT)
CJA: CJA_2896(cobT)
AVN: Avin_33050(cobU)
PCR: Pcryo_1026
PRW: PsycPRwf_0843
ACB: A1S_1660
ABY: ABAYE1993(cobT)
ABC: ACICU_01687
ABN: AB57_1885(cobT)
ABB: ABBFA_001837(cobT)
SON: SO_1035(cobT)
SFR: Sfri_0876(cobT)
SAZ: Sama_0762(cobT)
SBL: Sbal_3364(cobT)
SBM: Shew185_0977(cobT)
SBN: Sbal195_1011(cobT)
SBP: Sbal223_0999(cobT)
SLO: Shew_0714(cobT)
SPC: Sputcn32_2961(cobT)
SSE: Ssed_3734(cobT)
SPL: Spea_3380(cobT)
SHE: Shewmr4_0842(cobT)
SHM: Shewmr7_3180(cobT)
SHN: Shewana3_3278(cobT)
SHW: Sputw3181_0986(cobT)
SHL: Shal_3458(cobT)
SWD: Swoo_4084(cobT)
SWP: swp_0996(cobT)
CPS: CPS_3659
PHA: PSHAa2999(cobT)
PAT: Patl_1139
SDE: Sde_0630
MAQ: Maqu_0270
TTU: TERTU_3616(cobT)
MCA: MCA0463(cobT)
AEH: Mlg_2823
HHA: Hhal_1854
HCH: HCH_00964(cobT)
ABO: ABO_2378(cobT)
MMW: Mmwyl1_1409
TAU: Tola_1662 Tola_2005
CVI: CV_0493(cobT)
LHK: LHK_03224(cobT)
RSO: RSc2397(cobT)
RPI: Rpic_2663(cobT)
RPF: Rpic12D_2205
REU: Reut_A0658(cobT)
REH: H16_A2968(cobT)
RME: Rmet_2785(cobT)
CTI: RALTA_A2442(cobT)
BMA: BMA0688(cobT)
BMV: BMASAVP1_A2324(cobT)
BML: BMA10229_A2962(cobT)
BMN: BMA10247_1636(cobT)
BPS: BPSL0979(cobT)
BPM: BURPS1710b_1191(cobT)
BPL: BURPS1106A_1037
BPD: BURPS668_1031(cobT)
BPR: GBP346_A1029(cobT)
BTE: BTH_I0837(cobT)
BVI: Bcep1808_2537(cobT)
BUR: Bcep18194_A5784(cobT)
BCN: Bcen_1842(cobT)
BCH: Bcen2424_2453(cobT)
BCM: Bcenmc03_2458(cobT)
BCJ: BCAL2663(cobT)
BAM: Bamb_2501(cobT)
BAC: BamMC406_2369(cobT)
BMU: Bmul_0841(cobT)
BMJ: BMULJ_02417(cobT)
BXE: Bxe_A3499(cobT)
BPH: Bphy_2210(cobT)
BPY: Bphyt_0998(cobT)
BGL: bglu_1g28190
RFR: Rfer_2611
POL: Bpro_0741
PNA: Pnap_0642
AAV: Aave_1553
AJS: Ajs_3176
DAC: Daci_2816
DIA: Dtpsy_2527
VAP: Vapar_2566
CTT: CtCNB1_1856
MPT: Mpe_A2303 Mpe_A3126 Mpe_B0519(cobT)
HAR: HEAR0954(cobT)
MMS: mma_1087(cobT)
LCH: Lcho_2660 Lcho_3417
EBA: ebA4008(cobT)
AZO: azo3560(cobT)
DAR: Daro_0148(cobT)
TBD: Tbd_2712(cobT)
MFA: Mfla_0098
MMB: Mmol_0264
MEI: Msip34_0135
APP: CAP2UW1_1379
GSU: GSU3009(cobT)
GME: Gmet_0467(cobT)
GUR: Gura_4187(cobT)
GLO: Glov_3082(cobT) Glov_3678(cobT)
GBM: Gbem_3813(cobT)
GEO: Geob_0539
GEM: GM21_3897
PCA: Pcar_0486(cobT)
PPD: Ppro_2806(cobT)
DVU: DVU3279(cobT)
DVL: Dvul_0111
DVM: DvMF_2122
DDE: Dde_3777
DDS: Ddes_0891
DMA: DMR_38030(cobT)
DSA: Desal_0639
DBA: Dbac_0526
DPS: DP1952
DOL: Dole_2065
DAL: Dalk_0458
DAT: HRM2_06750(cobT1)
SCL: sce4943(cobT1) sce6908(cobT2)
HOH: Hoch_5267
SFU: Sfum_0323
MLO: mll0563(cobT) mlr1389
MES: Meso_1552
PLA: Plav_1058
SME: SMc04214(cobT)
SMD: Smed_1603(cobT)
ATU: Atu1890(cobT)
ATC: AGR_C_3467
ARA: Arad_2733(cobU)
AVI: Avi_2018
RET: RHE_CH02443(cobT)
REC: RHECIAT_CH0002544(cobT)
RLE: RL2781(cobT)
RLT: Rleg2_2081(cobT)
RLG: Rleg_2318
RHI: NGR_c17340(cobU)
BME: BMEI1099(cobT)
BMF: BAB1_0886(cobT)
BMB: BruAb1_0879(cobT)
BMC: BAbS19_I08270(cobT)
BMS: BR0867(cobT)
BMT: BSUIS_A0905(cobT)
BOV: BOV_0859(cobT)
BCS: BCAN_A0881(cobT)
BMR: BMI_I864
OAN: Oant_2360(cobT)
BJA: blr3276(cobT)
BRA: BRADO4918(cobT)
BBT: BBta_3133(cobT)
RPA: RPA0712(cobT) RPA2094(cobT1)
RPB: RPB_0742 RPB_3282
RPC: RPC_3748
RPD: RPD_0640 RPD_2324
RPE: RPE_2229 RPE_3845
RPT: Rpal_0783 Rpal_2384
BHE: BH08100(cobT)
BBK: BARBAKC583_0851(cobT)
BTR: Btr_1128(cobT)
BGR: Bgr_11220(cobT1)
XAU: Xaut_3321
AZC: AZC_3909
MEX: Mext_0911
MEA: Mex_1p0682(cobT)
MDI: METDI1054(cobT)
MRD: Mrad2831_1972
MET: M446_4382
MPO: Mpop_0847
MCH: Mchl_0872 Mchl_5702
MNO: Mnod_3775
BID: Bind_2029
MSL: Msil_1338
CCR: CC_1309
CCS: CCNA_01367
CAK: Caul_2047 Caul_2742
SIL: SPO1423(cobT)
SIT: TM1040_0578(cobT)
RSP: RSP_2428(cobT)
RSH: Rsph17029_1091(cobT)
RSQ: Rsph17025_1056(cobT)
RSK: RSKD131_0742
JAN: Jann_3305(cobT)
RDE: RD1_1827(cobT)
PDE: Pden_1567
DSH: Dshi_0788(cobT2)
HNE: HNE_1510 HNE_2095
HBA: Hbal_1436 Hbal_2151
NAR: Saro_0328
GBE: GbCGDNIH1_0669
GDI: GDI_0845(cobT)
GDJ: Gdia_1171
APT: APA01_22430
RRU: Rru_A0667
RCE: RC1_2371(cobT)
MAG: amb0542
MGM: Mmc1_3279
BHA: BH0284
BCG: BCG9842_B3399
GKA: GK1793
GTN: GTNG_1683(cobT)
GWC: GWCH70_1561
GYM: GYMC10_5183
GYC: GYMC61_2604
AFL: Aflv_2169
LSP: Bsph_1664
BBE: BBR47_12560(cobT)
PJD: Pjdr2_3352
AAC: Aaci_1947
SSA: SSA_0512
LRE: Lreu_1695
LRF: LAR_1583
CAC: CAC1372(cobT)
CPE: CPE1034(cobT)
CPF: CPF_1289(cobT)
CPR: CPR_1108(cobT)
CTC: CTC02290(cobT)
CNO: NT01CX_2077(cobT)
CTH: Cthe_1297(cobT)
CDF: CD3439(cobT)
CDC: CD196_3215(cobT)
CDL: CDR20291_3261(cobT)
CBK: CLL_A2928(cobT)
CBT: CLH_2674(cobT)
CBE: Cbei_1262(cobT)
CKL: CKL_2908(cobT)
CKR: CKR_2578
CPY: Cphy_1105
CCE: Ccel_0646
AMT: Amet_0464
SWO: Swol_1405
VPR: Vpar_1457
DSY: DSY2114(cobT)
DHD: Dhaf_3285
DRM: Dred_2728
DAE: Dtox_3581
PTH: PTH_0931(cobT)
DAU: Daud_1314
HMO: HM1_2401(cobT)
ERE: EUBREC_1925
CHY: CHY_0480(cobT)
MTA: Moth_1101 Moth_1721
ADG: Adeg_1690
MTU: Rv2207(cobT)
MTC: MT2263(cobT)
MRA: MRA_2223(cobT)
MTF: TBFG_12235(cobT)
MTB: TBMG_01774(TBMG_01774.1)
MBO: Mb2230(cobT)
MBB: BCG_2223(cobT)
MBT: JTY_2217(cobT)
MLE: ML0868(cobT)
MLB: MLBr_00868(cobT)
MPA: MAP1948(cobT)
MAV: MAV_2283(cobT)
MSM: MSMEG_4275(cobT)
MUL: MUL_3565(cobT)
MVA: Mvan_3571(cobT)
MGI: Mflv_2942(cobT)
MAB: MAB_1953c(cobT)
MMC: Mmcs_3305(cobT)
MKM: Mkms_3367(cobT)
MJL: Mjls_3316(cobT)
MMI: MMAR_3252(cobT)
CGL: NCgl2120(cobT)
CGB: cg2414(cobT)
CGT: cgR_2081(cobT)
CEF: CE2092(cobT)
CDI: DIP1634(cobT)
CJK: jk0711(cobT)
CUR: cur_1243
CAR: cauri_1705(cobT)
CKP: ckrop_0703(cobT)
NFA: nfa17000(cobT)
RHA: RHA1_ro01145(cobT)
RER: RER_36090(cobU)
ROP: ROP_08720
SCO: SCO2175(cobT)
SMA: SAV_6030(cobT)
SGR: SGR_5335(cobT) SGR_5983
PAC: PPA0441
NCA: Noca_2512 Noca_2886
TCU: Tcur_1322
SRO: Sros_7365
FRA: Francci3_3130(cobT)
FRE: Franean1_1785(cobT)
FAL: FRAAL5141(cobT)
ACE: Acel_0940
NML: Namu_0165
KRA: Krad_3274
SEN: SACE_1650(cobT)
SVI: Svir_08530 Svir_10570
AMI: Amir_1358
STP: Strop_3546
SAQ: Sare_3921
CAI: Caci_1840
RXY: Rxyl_0647
AFO: Afer_1832
SHI: Shel_21120
TDE: TDE0880(cobT)
LIL: LA4204(cobT)
LIC: LIC13356(cobT)
LBJ: LBJ_2826(cobT)
LBL: LBL_0245(cobT)
LBI: LEPBI_I2938(cobT)
LBF: LBF_2838(cobT)
BFR: BF2486
BFS: BF2519
BVU: BVU_3150
PGI: PG0702
PGN: PGN_0736
PDI: BDI_3956
DFE: Dfer_5375
CPI: Cpin_4484
FJO: Fjoh_0087
FPS: FP1460(bluB)
FNU: FN0910
LBA: Lebu_0558
STR: Sterm_1025
AMU: Amuc_1681
CTE: CT0946(cobT)
CPC: Cpar_1173(cobT)
CCH: Cag_1058(cobT)
CPH: Cpha266_0999(cobT)
CPB: Cphamn1_1492(cobT)
CLI: Clim_1079(cobT)
PVI: Cvib_0822(cobT)
PLT: Plut_1132(cobT)
PPH: Ppha_1294(cobT)
PAA: Paes_1254(cobT)
CTS: Ctha_0107
DET: DET0657(cobT-1) DET0691(cobT-2)
DEH: cbdb_A641(cobT)
DEB: DehaBAV1_0626
DEV: DhcVS_595(cobT)
RRS: RoseRS_0559
RCA: Rcas_0647
CAU: Caur_2578
CAG: Cagg_1277
CHL: Chy400_2787
HAU: Haur_3263
DRA: DR_A0240
DGE: Dgeo_2872
DDR: Deide_2p01840(cobT)
TTH: TT_P0005
TTJ: TTHB048
TLE: Tlet_1236
TME: Tmel_0695
TAF: THA_1065(cobT2)
FNO: Fnod_1365
KOL: Kole_0453
TYE: THEYE_A1179
HWA: HQ1408A(cobT)
NPH: NP0736A(cobT)
PTO: PTO0212
 |
|---|
| Structures |
PDB: 1D0S 1D0V 1JH8 1JHA 1JHM 1JHP 1JHQ 1JHR 1JHU 1JHV
1JHX 1JHY 1L4B 1L4E 1L4F 1L4G 1L4H 1L4K 1L4L 1L4M
1L4N 1L5F 1L5K 1L5L 1L5M 1L5N 1L5O 1WX1 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14253445]
FRIEDMANN HC.
PARTIAL PURIFICATION AND PROPERTIES OF A SINGLE DISPLACEMENT
TRANS-N-GLYCOSIDASE.
J. Biol. Chem. 240 (1965) 413-8.
Propionibacterium shermanii |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5780835]
Friedmann HC, Fyfe JA.
Pseudovitamin B 12 biosynthesis. Enzymatic formation of a new
adenylic acid, 7-alpha-D-ribofuranosyladenine 5'-phosphate.
J. Biol. Chem. 244 (1969) 1667-71.
Clostridium sticklandii |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4238408]
Fyfe JA, Friedmann HC.
Vitamin B 12 biosynthesis. Enzyme studies on the formation of the
alpha-glycosidic nucleotide precursor.
J. Biol. Chem. 244 (1969) 1659-66.
Propionibacterium shermanii, Clostridium sticklandii |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:1917841]
Cameron B, Blanche F, Rouyez MC, Bisch D, Famechon A, Couder M,
Cauchois L, Thibaut D, Debussche L, Crouzet J.
Genetic analysis, nucleotide sequence, and products of two
Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide:
dimethylbenzimidazole phosphoribosyltransferase and cobalamin
(5'-phosphate) synthase.
J. Bacteriol. 173 (1991) 6066-73.
Pseudomonas denitrificans |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:11441022]
Cheong CG, Escalante-Semerena JC, Rayment I.
Structural investigation of the biosynthesis of alternative lower
ligands for cobamides by nicotinate mononucleotide:
5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella
enterica.
J. Biol. Chem. 276 (2001) 37612-20.
Salmonella enterica |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:12101181]
Cheong CG, Escalante-Semerena JC, Rayment I.
Capture of a labile substrate by expulsion of water molecules from
the active site of nicotinate
mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase
(CobT) from Salmonella enterica.
J. Biol. Chem. 277 (2002) 41120-7.
Salmonella enterica |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.2.21
IUBMB Enzyme Nomenclature: 2.4.2.21
ExPASy - ENZYME nomenclature database: 2.4.2.21
BRENDA, the Enzyme Database: 2.4.2.21
CAS: 37277-76-2 |
|---|
