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Entry
EC 2.4.2.22                 Enzyme                                 
Name xanthine phosphoribosyltransferase;
Xan phosphoribosyltransferase;
xanthosine 5'-phosphate pyrophosphorylase;
xanthylate pyrophosphorylase;
xanthylic pyrophosphorylase;
XMP pyrophosphorylase;
5-phospho-alpha-D-ribose-1-diphosphate:xanthine
phospho-D-ribosyltransferase;
9-(5-phospho-beta-D-ribosyl)xanthine:diphosphate
5-phospho-alpha-D-ribosyltransferase
Class Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase
Reaction(IUBMB) XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate +
xanthine [RN:R02142]
Reaction(KEGG) R02142;
(other) R01229
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Substrate XMP [CPD:C00655];
diphosphate [CPD:C00013]
Product 5-phospho-alpha-D-ribose 1-diphosphate [CPD:C00119];
xanthine [CPD:C00385]
Pathway PATH: ec00230  Purine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00769  xanthine phosphoribosyltransferase
KO: K03816  xanthine phosphoribosyltransferase
Genes ECO: b0238(gpt)
ECJ: JW0228(gpt)
ECD: ECDH10B_0220(gpt)
EBW: BWG_0220(gpt)
ECE: Z0299(gpt)
ECS: ECs0265
ECF: ECH74115_0283(gpt)
ETW: ECSP_0272(gpt)
ECG: E2348C_0231(gpt)
ECC: c0384(gpt)
ECI: UTI89_C0278(gpt)
ECP: ECP_0267
ECV: APECO1_1731(gpt)
ECW: EcE24377A_0270(gpt)
ECX: EcHS_A0265(gpt)
ECM: EcSMS35_0292(gpt)
ECY: ECSE_0258
ECL: EcolC_3343
ECK: EC55989_0262(gpt)
ECQ: ECED1_0272(gpt)
ECR: ECIAI1_0277(gpt)
ECT: ECIAI39_0413(gpt)
ECZ: ECS88_0273(gpt)
EUM: ECUMN_0304(gpt)
ELF: LF82_0920(gpt)
EBL: B21_00236(gpt)
EBD: ECBD_3383
EBR: ECB_00233(gpt)
EOH: ECO103_0253(gpt)
EOI: ECO111_0300(gpt)
EOJ: ECO26_0294(gpt)
EFE: EFER_2740(gpt)
STY: STY0362(gpt)
STT: t2533(gpt)
SPT: SPA2438(gpt)
SEK: SSPA2276
SPQ: SPAB_03285
SEI: SPC_0328(gpt)
SEC: SC0318(gpt)
SEH: SeHA_C0358(gpt)
SEE: SNSL254_A0356(gpt)
SEW: SeSA_A0366(gpt)
SEA: SeAg_B0351(gpt)
SED: SeD_A0347(gpt)
SEG: SG0328(gpt)
SET: SEN0300(gpt)
SES: SARI_02695
STM: STM0317(gpt)
YPE: YPO3225(gpt)
YPK: y0963(gpt)
YPM: YP_0708(gpt)
YPA: YPA_2717
YPN: YPN_0868
YPG: YpAngola_A3304(gpt)
YPP: YPDSF_2854
YPS: YPTB0901(gpt)
YPI: YpsIP31758_3153(gpt)
YPY: YPK_3291
YPB: YPTS_0943
YEN: YE3205(gpp)
SFL: SF0286(gpt)
SFX: S0307(gpt)
SFV: SFV_0292(gpt)
SSN: SSON_0280(gpt)
SBO: SBO_0244(gpt)
SBC: SbBS512_E0235(gpt)
SDY: SDY_0479(gpt)
ECA: ECA3466(gpt)
PCT: PC1_3289
PWA: Pecwa_3436
ETA: ETA_25980(gpt)
PLU: plu1241(gpt)
PAY: PAU_03220
BUC: BU251(gpt)
BAS: BUsg242(gpt)
BAB: bbp232(gpt)
BAP: BUAP5A_246(gpt)
BAU: BUAPTUC7_248(gpt)
SGL: SG0598
ENT: Ent638_0764
ESA: ESA_03115
CTU: Ctu_08500(gpt)
KPN: KPN_00250(gpt)
KPE: KPK_4482(gpt)
KPU: KP1_1096(gpt)
CKO: CKO_02958
SPE: Spro_0964
PMR: PMI0366(gpt)
EIC: NT01EI_0912
ETR: ETAE_0793(gpt)
DDA: Dd703_0930
DDC: Dd586_3246
DZE: Dd1591_0897
HIN: HI0674(gptA) HI0692(gptB)
HIT: NTHI0796(gpt) NTHI0814(gpt2)
HIP: CGSHiEE_08725 CGSHiEE_08800
HIQ: CGSHiGG_06650 CGSHiGG_06750
HDU: HD1831(gpt)
HAP: HAPS_1466(gpt)
HSO: HS_0003(gptA)
HSM: HSM_1894
PMU: PM1369(gpt)
MSU: MS2117(apt)
APL: APL_0255(gpt)
APJ: APJL_0263(gpt)
APA: APP7_0257
ASU: Asuc_0179
AAP: NT05HA_2023
AAT: D11S_0732
VCH: VC2277
VCO: VC0395_A1867(gpt)
VCM: VCM66_2200(gpt)
VCJ: VCD_002065
VVU: VV1_0329
VVY: VV0855
VPA: VP0673
VHA: VIBHAR_01159
VSP: VS_2420
VEX: VEA_004271
VFI: VF_0738(gpt)
VFM: VFMJ11_0757
VSA: VSAL_I0975(gpt)
PPR: PBPRA0836
PAE: PA5298
PAU: PA14_69940(xpt)
PAP: PSPA7_6072(xpt)
PAG: PLES_56931
PPU: PP_5265(xpt)
PPF: Pput_5175
PPG: PputGB1_5317
PPW: PputW619_0205
PST: PSPTO_0112(xpt)
PSB: Psyr_0076
PSP: PSPPH_0081(xpt)
PFL: PFL_6032(xpt)
PFO: Pfl01_5520
PFS: PFLU5962(xpt)
PEN: PSEEN5411(xpt)
PMY: Pmen_0251
PSA: PST_0487(xpt)
AVN: Avin_47930(xpt)
ACI: ACIAD3164(xpt)
ACB: A1S_3035
ABM: ABSDF0471(xpt)
ABY: ABAYE0456(xpt)
ABC: ACICU_03231
ABN: AB57_3483(xpt)
ABB: ABBFA_000483(xpt)
SPL: Spea_2433
SHL: Shal_1847
ILO: IL0887(gpt)
HCH: HCH_01089
CSA: Csal_2097
MMW: Mmwyl1_3674
AHA: AHA_3424(gpt)
ASA: ASA_0890(gpt)
TAU: Tola_0808
LHK: LHK_00303(xpt)
HPY: HP0735
HPJ: jhp0672(gpt)
HPA: HPAG1_0719
HPS: HPSH_03165
HPG: HPG27_691
HPP: HPP12_0744(gpt)
HPB: HELPY_0632
HAC: Hac_0684(gpt)
WSU: WS2175
TDN: Suden_0395
CJE: Cj1370
CJR: CJE1562
CJJ: CJJ81176_1373
CJU: C8J_1289
CJD: JJD26997_0280
CFF: CFF8240_0582
CCV: CCV52592_0222
CHA: CHAB381_0833
CCO: CCC13826_1485(cadF)
CLA: Cla_0429
ABU: Abu_0867
SDL: Sdel_1684
NIS: NIS_0649
SUN: SUN_1505
NAM: NAMH_0531
DVU: DVU1066(gpt)
DVL: Dvul_1928
DVM: DvMF_3025
DDE: Dde_1506
DSA: Desal_2452
DBA: Dbac_3234
DRT: Dret_0213
DPS: DP0680
DAT: HRM2_02560(xpt)
ADE: Adeh_1006
ACP: A2cp1_1067
AFW: Anae109_3172
ANK: AnaeK_1064
SAT: SYN_03353
MLO: mll0141
MES: Meso_1335
SME: SMc00945(gpt)
SMD: Smed_1386
ATU: Atu1731(gpt)
ATC: AGR_C_3180(gpt)
ARA: Arad_2052(gpt)
AVI: Avi_2602(gpt)
RET: RHE_CH01754(gpt)
REC: RHECIAT_CH0001840(gpt)
RLE: RL1948(gpt)
RLT: Rleg2_1415
RLG: Rleg_1591
RHI: NGR_c14770(gpt)
BME: BMEI0940
BMF: BAB1_1066
BMC: BAbS19_I09880
BMS: BR1046
BMT: BSUIS_A1089(gpt)
BCS: BCAN_A1060(gpt)
BMR: BMI_I1049
OAN: Oant_2133
BJA: bll5610(gpt)
BRA: BRADO2909(gpt)
BBT: BBta_5270(gpt)
RPA: RPA2179
RPB: RPB_3213
RPC: RPC_3155
RPD: RPD_2243
RPE: RPE_2299
RPT: Rpal_2473
NWI: Nwi_2188
NHA: Nham_2590
OCA: OCAR_5508
MET: M446_6953
MNO: Mnod_7666
BID: Bind_1131
MSL: Msil_2116
SIL: SPO2143(gpt)
SIT: TM1040_1146
RSP: RSP_2342(gpt)
RSH: Rsph17029_1017
RSQ: Rsph17025_1049
RSK: RSKD131_0668
JAN: Jann_2477
RDE: RD1_3201(gpt)
PDE: Pden_0855
DSH: Dshi_1793(gpt)
ZMO: ZMO0656
ZMN: Za10_0610
GOX: GOX0174
GBE: GbCGDNIH1_1116
ACR: Acry_2747
GDI: GDI_3218(gpt)
GDJ: Gdia_3143
APT: APA01_17640
RRU: Rru_A3319
RCE: RC1_2738
MAG: amb4308
BSU: BSU22070(xpt)
BHA: BH1514
BAN: BA1591(xpt)
BAR: GBAA1591(xpt)
BAA: BA_2109
BAT: BAS1475
BAH: BAMEG_3002(xpt)
BAI: BAA_1660(xpt)
BCE: BC1569
BCA: BCE_1697(xpt)
BCZ: BCZK1448(xpt)
BCR: BCAH187_A1737(xpt)
BCB: BCB4264_A1626(xpt)
BCU: BCAH820_1661(xpt)
BCG: BCG9842_B3719(xpt)
BCQ: BCQ_1635(xpt)
BCX: BCA_1628(xpt)
BCY: Bcer98_1302
BTK: BT9727_1447(xpt)
BTL: BALH_1417
BWE: BcerKBAB4_1490
BLI: BL00680(xpt)
BLD: BLi02348(xpt)
BCL: ABC1443(xpt)
BAY: RBAM_020260(xpt)
BPU: BPUM_1944(xpt)
OIH: OB1061
GTN: GTNG_1397(xpt)
GYM: GYMC10_0727
GYC: GYMC61_2387
SAU: SA0373(xprT)
SAV: SAV0388(xprT)
SAW: SAHV_0385(xprT)
SAM: MW0364(xprT)
SAR: SAR0406(xpt)
SAS: SAS0364
SAC: SACOL0458(xpt)
SAB: SAB0338(xpt)
SAA: SAUSA300_0386(xpt)
SAX: USA300HOU_0411(xprT)
SAO: SAOUHSC_00372
SAJ: SaurJH9_0435
SAH: SaurJH1_0446
SAE: NWMN_0378
SAD: SAAV_0355(xpt)
SEP: SE2350
SER: SERP0067(xpt)
SHA: SH2585(xprT)
SSP: SSP2325
SCA: Sca_0047(xprT)
LMO: lmo1885
LMF: LMOf2365_1914(xpt)
LMH: LMHCC_0672(xpt)
LMC: Lm4b_01901
LIN: lin1998
LWE: lwe1904(xpt)
LSP: Bsph_0743
ESI: Exig_0219
EAT: EAT1b_1976
MCL: MCCL_1944(xprT)
BBE: BBR47_44140(xpt)
PJD: Pjdr2_1053 Pjdr2_2159 Pjdr2_3999
LLA: L159396(xpt)
LLK: LLKF_1171(xpt)
LLC: LACR_1265
LLM: llmg_1346(xpt)
SPY: SPy_1136(xpt)
SPZ: M5005_Spy_0858(xpt)
SPM: spyM18_1096(xpt)
SPG: SpyM3_0794(xpt)
SPS: SPs0993
SPH: MGAS10270_Spy0972(xpt)
SPI: MGAS10750_Spy1007(xpt)
SPJ: MGAS2096_Spy0932(xpt)
SPK: MGAS9429_Spy0975(xpt)
SPF: SpyM50932(xpt)
SPA: M6_Spy0854
SPB: M28_Spy0832(xpt)
SOZ: Spy49_0887(xpt)
SPN: SP_1847
SPD: SPD_1628(xpt)
SPR: spr1662(xpt)
SPW: SPCG_1821(xpt)
SPX: SPG_1731(xpt)
SNE: SPN23F_18620(xpt)
SPV: SPH_1962(xpt)
SNM: SP70585_1901(xpt)
SJJ: SPJ_1752(xpt)
SPP: SPP_1846(xpt)
SNT: SPT_1764(xpt)
SAG: SAG1086(xpt)
SAN: gbs1117
SAK: SAK_1171(xpt)
STC: str1337(xpt)
STL: stu1338
SSA: SSA_1134(xpt)
SGO: SGO_1158(xpt)
SEQ: SZO_09300
SEZ: Sez_1035(xpt)
SEU: SEQ_1154
SUB: SUB0866(xpt)
SDS: SDEG_0895(xpt)
LPL: lp_1139(xpt)
LPJ: JDM1_0936(xpt)
LJO: LJ0227
LJF: FI9785_302(xpt)
LAC: LBA0240
LSA: LSA1557(xpt)
LSL: LSL_1309(xpt)
LDB: Ldb0296(xpt)
LBU: LBUL_0250
LBR: LVIS_1636
LCA: LSEI_1117
LCB: LCABL_12770(xpt)
LGA: LGAS_0229
LRE: Lreu_1447
LRF: LAR_1358
LHE: lhv_0253
LFE: LAF_1478
LRH: LGG_01076(xpt)
LRL: LC705_01153(xpt)
PPE: PEPE_1374
EFA: EF2365(xpt)
OOE: OEOE_0537
LME: LEUM_2059
LCI: LCK_01705
CAC: CAC0873(xpt)
CPE: CPE0335(xpt) CPE1292(xpt)
CPF: CPF_0319(xpt) CPF_1498(xpt)
CPR: CPR_0313(xpt) CPR_1287(xpt)
CTC: CTC02386
CNO: NT01CX_0402
CDF: CD2330(xpt)
CDC: CD196_2173(xpt)
CDL: CDR20291_2219(xpt)
CBO: CBO0317(xpt) CBO1139(xpt)
CBA: CLB_0360(xpt-1) CLB_1176(xpt-2)
CBH: CLC_0375(xpt-1) CLC_1188(xpt-2)
CBY: CLM_0385(xpt) CLM_1295(xpt)
CBL: CLK_0579(xpt) CLK_3506(xpt)
CBK: CLL_A1697(xpt)
CBB: CLD_0436(xpt) CLD_3424(xpt)
CBI: CLJ_B0371(xpt_1) CLJ_B1186(xpt_2)
CBT: CLH_1899(xpt)
CBF: CLI_0387(xpt-1) CLI_1225(xpt-2)
CBE: Cbei_2427
CPY: Cphy_3381
CCE: Ccel_1405
AMT: Amet_3326
VPR: Vpar_0363
DRM: Dred_2173
HMO: HM1_1451(xpt)
FMA: FMG_1031
APR: Apre_0380
EEL: EUBELI_01491
ERE: EUBREC_1763
MTA: Moth_0720
BLO: BL0891(xpt)
BLJ: BLD_0628(apt2)
BLN: Blon_1617
BAD: BAD_0692(xpt)
BLA: BLA_1460(xpt)
BLC: Balac_0946
BLT: Balat_0946
SHI: Shel_17850
ELE: Elen_2968
BTH: BT_0427
BFR: BF1692
BFS: BF1699
BVU: BVU_2532
PGI: PG2147(xpt)
PGN: PGN_0195
PDI: BDI_1502
FSU: Fisuc_1663
STR: Sterm_2755
TAI: Taci_0457
SYG: sync_1158
CAU: Caur_1419
CAG: Cagg_2135
CHL: Chy400_1541
DRA: DR_1617
DGE: Dgeo_0491
DDR: Deide_04030(xpt)
MMA: MM_0078
PTO: PTO0589
Taxonomy
Structures PDB: 1A95  1A96  1A97  1A98  1NUL  2FXV  
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:4910918]
Krenitsky TA, Neil SM, Miller RL.
Guanine and xanthine phosphoribosyltransfer activities of
Lactobacillus casei and Escherichia coli. Their relationship to
hypoxanthine and adenine phosphoribosyltransfer activities.
J. Biol. Chem. 245 (1970) 2605-11.
Lactobacillus casei [GN:lca], Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 2.4.2.22
IUBMB Enzyme Nomenclature: 2.4.2.22
ExPASy - ENZYME nomenclature database: 2.4.2.22
BRENDA, the Enzyme Database: 2.4.2.22
CAS: 9023-10-3
DBGET integrated database retrieval system