KEGG   ENZYME: 2.4.2.26Help
Entry
EC 2.4.2.26                 Enzyme                                 

Name
protein xylosyltransferase;
UDP-D-xylose:core protein beta-D-xylosyltransferase;
UDP-D-xylose:core protein xylosyltransferase;
UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase;
UDP-xylose-core protein beta-D-xylosyltransferase;
uridine diphosphoxylose-core protein beta-xylosyltransferase;
uridine diphosphoxylose-protein xylosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
UDP-D-xylose:protein beta-D-xylosyltransferase
Reaction(IUBMB)
Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate [RN:R05925]
Reaction(KEGG)
R05925(G)
Show
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates).
History
EC 2.4.2.26 created 1976, modified 2002
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Metabolic pathways
Orthology
K00771  
protein xylosyltransferase
Genes
HSA: 
64131(XYLT1) 64132(XYLT2)
PTR: 
453955(XYLT1) 455118(XYLT2)
PPS: 
100970715(XYLT1) 100973069(XYLT2)
GGO: 
101133399(XYLT2) 101134207(XYLT1)
PON: 
100434979(XYLT1) 100459725(XYLT2)
MCC: 
705139(XYLT2) 718187
MCF: 
102133732(XYLT2) 102145035(XYLT1)
MMU: 
217119(Xylt2) 233781(Xylt1)
RNO: 
64133(Xylt1) 64134(Xylt2)
CGE: 
HGL: 
101703898(Xylt2) 101726675(Xylt1)
TUP: 
102477995(XYLT2) 102483871(XYLT1)
CFA: 
493990(XYLT2) 494008(XYLT1)
AML: 
FCA: 
101099511(XYLT2)
PTG: 
102968094(XYLT2) 102968197(XYLT1)
BTA: 
493989(XYLT2) 541295(XYLT1)
BOM: 
102280747(XYLT2) 102281178(XYLT1)
PHD: 
102321893(XYLT1) 102339963(XYLT2)
CHX: 
102178593(XYLT1) 102188252(XYLT2)
SSC: 
100514160(XYLT1) 100514793(XYLT2)
CFR: 
102509305(XYLT2) 102515495(XYLT1)
ECB: 
100053250(XYLT1) 100069884(XYLT2)
MYB: 
MYD: 
102761761(XYLT1) 102772248(XYLT2)
PALE: 
102887640(XYLT2)
MDO: 
SHR: 
100929128(XYLT1) 100934708(XYLT2)
OAA: 
100087573(XYLT1)
GGA: 
414780(XYLT2) 414781(XYLT1)
MGP: 
TGU: 
FAB: 
101808039(XYLT1) 101813773(XYLT2)
PHI: 
102101523(XYLT1) 102112563(XYLT2)
APLA: 
101801382(XYLT2) 101802041(XYLT1)
FPG: 
FCH: 
CLV: 
102085335(XYLT1) 102089671(XYLT2)
ASN: 
PSS: 
CMY: 
ACS: 
XLA: 
444363(xylt1)
XTR: 
100145490(xylt1) 448400(xylt2)
DRE: 
560951(xylt1) 563446(xylt2)
TRU: 
MZE: 
OLA: 
100049390(xt-ib) 100049492(xt-ii)
XMA: 
LCM: 
CIN: 
619275(xt)
SPU: 
585774(xylt1)
DME: 
DPO: 
Dpse_GA16815(Dpse_oxt)
DAN: 
Dana_GF24873(Dana_oxt)
DER: 
Dere_GG14524(Dere_oxt)
DPE: 
Dper_GL24622(Dper_oxt)
DSE: 
Dsec_GM14129(Dsec_oxt)
DSI: 
Dsim_GD13401(Dsim_oxt)
DWI: 
Dwil_GK12594(Dwil_oxt)
DYA: 
Dyak_GE21716(Dyak_oxt)
DGR: 
DMO: 
DVI: 
Dvir_GJ13432(Dvir_oxt)
AGA: 
AAG: 
CQU: 
AME: 
413854(oxt)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG17882(Cbr-sqv-6)
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
GMX: 
MTR: 
POP: 
POPTR_0008s00710g(POPTRDRAFT_720100)
DOSA: 
Os01t0201100-01(Os01g0201100)
ZMA: 
SITA: 
SMO: 
CCP: 
MBR: 
ACAN: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:5030630]
  Authors
Stoolmiller AC, Horwitz AL, Dorfman A.
  Title
Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase.
  Journal
J. Biol. Chem. 247 (1972) 3525-32.
  Organism
Bos taurus
Reference
2  [PMID:11099377]
  Authors
Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K.
  Title
Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II.
  Journal
J. Mol. Biol. 304 (2000) 517-28.
  Organism
Homo sapiens, Rattus norvegicus
  Sequence
[hsa:64131 64132] [rno:64133 64134]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
55576-38-0

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