KEGG   ENZYME: 2.4.2.26Help
Entry
EC 2.4.2.26                 Enzyme                                 
Name
protein xylosyltransferase;
UDP-D-xylose:core protein beta-D-xylosyltransferase;
UDP-D-xylose:core protein xylosyltransferase;
UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase;
UDP-xylose-core protein beta-D-xylosyltransferase;
uridine diphosphoxylose-core protein beta-xylosyltransferase;
uridine diphosphoxylose-protein xylosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
UDP-D-xylose:protein beta-D-xylosyltransferase
Reaction(IUBMB)
Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate [RN:R05925]
Reaction(KEGG)
R05925(G)
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Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates).
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Metabolic pathways
Orthology
K00771  
protein xylosyltransferase
Genes
HSA: 
64131(XYLT1) 64132(XYLT2)
PTR: 
453955(XYLT1) 455118(XYLT2)
PPS: 
100970715(XYLT1) 100973069(XYLT2)
GGO: 
101133399(XYLT2) 101134207(XYLT1)
PON: 
100434979(XYLT1) 100459725(XYLT2)
MCC: 
705139(XYLT2) 718187
MMU: 
217119(Xylt2) 233781(Xylt1)
RNO: 
64133(Xylt1) 64134(Xylt2)
CFA: 
493990(XYLT2) 494008(XYLT1)
AML: 
FCA: 
101099511(XYLT2)
BTA: 
493989(XYLT2) 541295(XYLT1)
SSC: 
100514160(XYLT1) 100514793
ECB: 
100053250(XYLT1) 100069884
MDO: 
100012411 100018495(XYLT1)
SHR: 
100929128(XYLT1) 100934708(XYLT2)
OAA: 
100087573(XYLT1)
GGA: 
414780(XYLT2) 414781(XYLT1)
MGP: 
100539167
TGU: 
100223613(XYLT2) 100228294
ACS: 
100567768
XLA: 
444363(xylt1)
XTR: 
100145490(xylt1) 448400(xylt2)
DRE: 
560951(xylt1) 563446(xylt2)
TRU: 
101063640 101067123
OLA: 
100049390(xt-ib) 100049492(xt-ii)
CIN: 
619275(xt)
SPU: 
585774(xylt1)
DME: 
Dmel_CG32300(oxt)
DPO: 
Dpse_GA16815(Dpse_oxt)
DAN: 
Dana_GF24873(Dana_oxt)
DER: 
Dere_GG14524(Dere_oxt)
DPE: 
Dper_GL24622(Dper_oxt)
DSE: 
Dsec_GM14129(Dsec_oxt)
DSI: 
Dsim_GD13401(Dsim_oxt)
DWI: 
Dwil_GK12594(Dwil_oxt)
DYA: 
Dyak_GE21716(Dyak_oxt)
DGR: 
Dgri_GH16481
DMO: 
Dmoj_GI12152
DVI: 
Dvir_GJ13432(Dvir_oxt)
AGA: 
AgaP_AGAP005811
AAG: 
AaeL_AAEL007409
CQU: 
CpipJ_CPIJ019812
AME: 
413854(oxt)
NVI: 
100120497(NV12679)
TCA: 
657929
API: 
100163472
PHU: 
Phum_PHUM187000
ISC: 
IscW_ISCW015483
CEL: 
CELE_Y50D4C.4(sqv-6)
CBR: 
CBG17882(Cbr-sqv-6)
TSP: 
Tsp_08280
SMM: 
Smp_128310.1
NVE: 
NEMVE_v1g118618
TAD: 
TRIADDRAFT_21022
AQU: 
100635901
GMX: 
100820204
MTR: 
MTR_4g022240
DOSA: 
Os01t0201100-01(Os01g0201100)
MBR: 
MONBRDRAFT_30261
 » show all
Taxonomy
Reference
1  [PMID:5030630]
  Authors
Stoolmiller AC, Horwitz AL, Dorfman A.
  Title
Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase.
  Journal
J. Biol. Chem. 247 (1972) 3525-32.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:11099377]
  Authors
Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K.
  Title
Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II.
  Journal
J. Mol. Biol. 304 (2000) 517-28.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
55576-38-0
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