KEGG   ENZYME: 2.4.2.28Help
Entry
EC 2.4.2.28                 Enzyme                                 
Name S-methyl-5'-thioadenosine phosphorylase;
5'-methylthioadenosine nucleosidase;
5'-deoxy-5'-methylthioadenosine phosphorylase;
MTA phosphorylase;
MeSAdo phosphorylase;
MeSAdo/Ado phosphorylase;
methylthioadenosine phosphorylase;
methylthioadenosine nucleoside phosphorylase;
5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase;
S-methyl-5-thioadenosine phosphorylase;
S-methyl-5-thioadenosine:phosphate
S-methyl-5-thio-alpha-D-ribosyl-transferase
Class Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname S-methyl-5'-thioadenosine:phosphate
S-methyl-5-thio-alpha-D-ribosyl-transferase
Reaction(IUBMB) S-methyl-5'-thioadenosine + phosphate = adenine +
S-methyl-5-thio-alpha-D-ribose 1-phosphate [RN:R01402]
Reaction(KEGG) R01402
Show
Substrate S-methyl-5'-thioadenosine [CPD:C00170];
phosphate [CPD:C00009]
Product adenine [CPD:C00147];
S-methyl-5-thio-alpha-D-ribose 1-phosphate [CPD:C04188]
Comment Also acts on 5'-deoxyadenosine and other analogues having 5'-deoxy
groups.
Pathway PATH: ec00270  Cysteine and methionine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00772  5'-methylthioadenosine phosphorylase
Genes HSA: 4507(MTAP)
PTR: 742857(MTAP)
MCC: 709020(MTAP)
MMU: 66902(Mtap)
RNO: 298227(Mtap)
CFA: 474729(MTAP)
BTA: 782907
SSC: 100155326
ECB: 100065392
MDO: 100021660
OAA: 100075183
GGA: 431261(MTAP)
TGU: 100228406
XTR: 496996(mtap)
DRE: 393526(mtap)
CIN: 100177521
SPU: 580214
DME: Dmel_CG4802
DPO: Dpse_GA18442
DAN: Dana_GF13119
DER: Dere_GG20677
DPE: Dper_GL11423
DSE: Dsec_GM21772
DSI: Dsim_GD11265
DYA: Dyak_GE11660
DGR: Dgri_GH21396
DMO: Dmoj_GI18575
AGA: AgaP_AGAP005129
AAG: AaeL_AAEL012172
CQU: CpipJ_CPIJ002278
AME: 552740
NVI: 100114672
TCA: 655565
API: 100163548
ISC: IscW_ISCW009267
CEL: B0228.7
CBR: CBG12968
BMY: Bm1_42810
SMM: Smp_028190
HMG: 100198432
TAD: TRIADDRAFT_58826
SCE: YLR017W(MEU1)
AGO: AGOS_AAL160W
KLA: KLLA0F15664g
LTH: KLTH0B03344g
DHA: DEHA0C13145g
PIC: PICST_65182
VPO: Kpol_2002p102
LEL: LELG_02245
ZRO: ZYRO0B10384g
CAL: CaO19.14200(MEU1)
CTP: CTRG_06211
CDU: CD36_83770
CGR: CAGL0D03190g
YLI: YALI0B13420g
SPO: SPAC16C9.02c
NCR: NCU03963
PAN: PODANSg3201
MGR: MGG_06498
FGR: FG08458.1
ANI: AN1735.2
AFM: AFUA_6G08720
AOR: AO090001000546
ANG: An11g06110
AFV: AFLA_128500
PCS: Pc12g08930
NFI: NFIA_054370
CIM: CIMG_01361
SSL: SS1G_02233
BFU: BC1G_04337
CNE: CNA01530
CNB: CNBA1480
LBC: LACBIDRAFT_310905
MPR: MPER_10772
UMA: UM00570.1
MGL: MGL_2916
PYO: PY07728
TBR: Tb927.7.7040
TCR: 506789.280 508387.20
LMA: LmjF05.0830
LIF: LinJ05.0840
LBZ: LbrM05_V2.0800
PCT: PC1_3476
XFA: XF2353
XFT: PD1381
XFM: Xfasm12_1523
XFN: XfasM23_1466
XCC: XCC1285(deoD)
XCB: XC_2956
XCA: xccb100_3018
XCV: XCV1388(deoD)
XAC: XAC1336(deoD)
XOO: XOO1869(deoD)
XOM: XOO_1764
XOP: PXO_01730
SML: Smlt3536
SMT: Smal_2966
PAE: PA3004
PAU: PA14_25210
PAP: PSPA7_2155(mtnP)
PAG: PLES_20581
PST: PSPTO_3506
PSB: Psyr_3280
PSP: PSPPH_3200(mtaP)
PFO: Pfl01_3869
PMY: Pmen_1591
PSA: PST_1738
CJA: CJA_0572
AVN: Avin_14550
PAR: Psyc_1155(deoD)
PCR: Pcryo_1251
SDE: Sde_1793
MAQ: Maqu_1935
MCA: MCA1986
NOC: Noc_0457
AEH: Mlg_1329
HHA: Hhal_1259
TGR: Tgr7_1751
HNA: Hneap_1396
HCH: HCH_02681(mtaP)
ABO: ABO_1021(deoD)
AFE: Lferr_0535
AFR: AFE_0365(mtaP)
CVI: CV_1400 CV_3894
LHK: LHK_02867
BGL: bglu_2p1030
RFR: Rfer_3751
NEU: NE1754
NET: Neut_0945
NMU: Nmul_A0650
EBA: ebA6375
AZO: azo1998
DAR: Daro_1738
TMZ: Tmz1t_2182
TBD: Tbd_0778
MFA: Mfla_1467
MMB: Mmol_1175
MEI: Msip34_1418
APP: CAP2UW1_3627
GSU: GSU1112(mtaP)
GME: Gmet_2684
GUR: Gura_1582
GLO: Glov_3607
GBM: Gbem_1656
GEO: Geob_3544
GEM: GM21_2557
PCA: Pcar_2021(mtaP)
PPD: Ppro_0431
DMA: DMR_26000(mtaP)
DSA: Desal_1601
DOL: Dole_2618
DAT: HRM2_05190
ADE: Adeh_1180
ACP: A2cp1_2786
AFW: Anae109_3381
ANK: AnaeK_2691
MXA: MXAN_5935 MXAN_6386(mtaP)
SCL: sce3763(mtaP)
HOH: Hoch_6331
MLO: mlr7546
MES: Meso_2403
PLA: Plav_2245
BJA: blr0960
BRA: BRADO6904
BBT: BBta_0647(mtaP)
RPA: RPA4821
RPB: RPB_4698
RPC: RPC_4937
RPD: RPD_4408
RPE: RPE_4907
RPT: Rpal_5308
MEX: Mext_2545
MEA: Mex_1p2512
MDI: METDI3275
MRD: Mrad2831_0466
MET: M446_6795
MPO: Mpop_2475
MCH: Mchl_2768
MNO: Mnod_7534
BID: Bind_0158
MSL: Msil_2145
SIL: SPO3060(mtaP)
SIT: TM1040_2324
RSP: RSP_1837
RSH: Rsph17029_0486
RSQ: Rsph17025_0626
RSK: RSKD131_0144
JAN: Jann_3207
RDE: RD1_2150
DSH: Dshi_2068
MMR: Mmar10_0739
HNE: HNE_0354(mtaP)
HBA: Hbal_0748
SWI: Swit_1393
ELI: ELI_01490
GOX: GOX1897
GBE: GbCGDNIH1_1721
ACR: Acry_2947
GDI: GDI_2055(deoD)
GDJ: Gdia_0276
APT: APA01_08090
RRU: Rru_A0361
MAG: amb4121
AAC: Aaci_1647
CTH: Cthe_0622
STH: STH1696 STH814 STH815
SWO: Swol_0778
VPR: Vpar_0949
ATE: Athe_1361 Athe_1782
DSY: DSY2604
DHD: Dhaf_3766
DRM: Dred_2065
DAE: Dtox_1185
PTH: PTH_1731(pnp)
DAU: Daud_0647
HMO: HM1_0100(pnp) HM1_2176(mtaP)
TTE: TTE1587(pnp2)
TEX: Teth514_1878
TPD: Teth39_0882
CHY: CHY_1441(mtaP)
MTA: Moth_0705
ADG: Adeg_0963
CSC: Csac_1924 Csac_2325
CPO: COPRO5265_0713
MTU: Rv0535(pnp)
MTC: MT0559(mtaP)
MRA: MRA_0542(pnp)
MTF: TBFG_10546
MTB: TBMG_00541(TBMG_00541.1)
MBO: Mb0549(pnp)
MBB: BCG_0579(pnp)
MBT: JTY_0549(pnp)
MPA: MAP4030(pnp)
MAV: MAV_4610(mtaP)
MSM: MSMEG_0990(mtaP)
MUL: MUL_0634(pnp)
MVA: Mvan_0881
MAB: MAB_3956c
MMC: Mmcs_0703
MKM: Mkms_0717
MJL: Mjls_0697
MMI: MMAR_0881(pnp)
NFA: nfa8440
RHA: RHA1_ro02578 RHA1_ro04261
ROP: ROP_23030(mtaP) ROP_41740(mtaP)
SCO: SCO3188(SCE22.05)
SMA: SAV_3679(mtaP)
SGR: SGR_4290
CMI: CMM_2317
CMS: CMS_2496
RSA: RSal33209_0691 RSal33209_0692
BCV: Bcav_3088
NCA: Noca_2340
TCU: Tcur_0904
SRO: Sros_8654
ACE: Acel_0158
STP: Strop_0986 Strop_1035
SAQ: Sare_0922
RXY: Rxyl_0606
LIL: LA4248
LIC: LIC13399(mtaP)
LBJ: LBJ_2920
LBL: LBL_0143
LBI: LEPBI_I0071
LBF: LBF_0071
ABA: Acid345_2626
ACA: ACP_3357(mtaP)
SUS: Acid_7058
SRU: SRU_2160(mtaP)
OTE: Oter_1925
RSD: TGRD_317
SYN: sll0135
SYW: SYNW1265
SYC: syc0619_d
SYF: Synpcc7942_0923
SYD: Syncc9605_1392
SYE: Syncc9902_1096
SYG: sync_1385(mtaP)
SYR: SynRCC307_1356
SYX: SynWH7803_1250
SYP: SYNPCC7002_A0108(mtaP)
TEL: tlr1281
MAR: MAE_45240
CYT: cce_1181
CYP: PCC8801_4009
CYC: PCC7424_2582
CYN: Cyan7425_3520
CYH: Cyan8802_4047
GVI: gll2424
ANA: alr4054
NPU: Npun_F6610
AVA: Ava_1653
PMA: Pro0332(pnp)
PMM: PMM0301
PMT: PMT1900
PMN: PMN2A_1666
PMI: PMT9312_0303
PMB: A9601_03241
PMC: P9515_03341
PMF: P9303_25331
PMG: P9301_03251
PMH: P9215_03261
PMJ: P9211_03271
PME: NATL1_03801
TER: Tery_3686
AMR: AM1_0617(mtaP)
DET: DET0517(mtaP)
DEH: cbdb_A482(mtaP)
DEB: DehaBAV1_0493
DEV: DhcVS_458(mtaP)
RRS: RoseRS_3664
RCA: Rcas_1474
CAU: Caur_3616
CAG: Cagg_0365
CHL: Chy400_3901
HAU: Haur_1131 Haur_1132 Haur_4909
TRO: trd_0837(mtaP)
STI: Sthe_1161
AAE: aq_568(deoD)
HYA: HY04AAS1_0134
SUL: SYO3AOP1_1135
SAF: SULAZ_1645(mtnP)
PMX: PERMA_0933(mtnP)
DTH: DICTH_0779(mtaP)
DTU: Dtur_0928
TYE: THEYE_A0977
MJA: MJ0060
MFE: Mefer_0904
MVU: Metvu_1143
MMP: MMP0185(mtaP)
MMQ: MmarC5_1491
MMX: MmarC6_0767
MMZ: MmarC7_1184
MAE: Maeo_0926
MVN: Mevan_1187
MAC: MA1409
MBA: Mbar_A3594
MMA: MM_2379
MBU: Mbur_0182
MHU: Mhun_1049
MLA: Mlab_1053
MEM: Memar_1088
MBN: Mboo_0767
MPL: Mpal_1028
MPD: MCP_1821 MCP_2403
MST: Msp_0642
MSI: Msm_0665
MKA: MK0021(pnp)
AFU: AF1788(mtaP)
HAL: VNG0335a VNG0335b
HWA: HQ1262A(mtaP)
HLA: Hlac_0422
TAC: Ta0332
TVO: TVN0438
PTO: PTO0123 PTO0942
PHO: PH0125 PH1143
PAB: PAB1659 PAB2264(mtaP)
PFU: PF0016 PF0853
TKO: TK1482 TK1895
TON: TON_0128 TON_1651
TGA: TGAM_0135(mtaP-1) TGAM_1953(mtaP-2)
TSI: TSIB_1419 TSIB_1981
RCI: RCIX2368
APE: APE_0993.1(mtaP) APE_1885
SMR: Smar_0518 Smar_0749
IHO: Igni_0351 Igni_1103
DKA: DKAM_0803 DKAM_1046
HBU: Hbut_0022 Hbut_0922
SSO: SSO2343(mtaP) SSO2706(mtaP)
STO: ST0485 ST0975
SAI: Saci_0997 Saci_1247(mtaP)
SIS: LS215_0171 LS215_2770
SIA: M1425_0140 M1425_2610
SIM: M1627_0140 M1627_2663
SID: M164_0159 M164_2594
SIY: YG5714_0144 YG5714_2779
SIN: YN1551_2743 YN1551_2969
MSE: Msed_0689 Msed_1578
PAI: PAE1476 PAE3338
PIS: Pisl_0582 Pisl_1572
PCL: Pcal_0435 Pcal_0814
PAS: Pars_0610 Pars_1752
CMA: Cmaq_1546 Cmaq_1577
TNE: Tneu_0603 Tneu_1572
TPE: Tpen_0060 Tpen_0062 Tpen_0126 Tpen_0618
NMR: Nmar_1401
KCR: Kcr_0284 Kcr_1502
Taxonomy
Structures PDB: 1CB0  1CG6  1JDS  1JDT  1JDU  1JDV  1JDZ  1JE0  1JE1  1JP7  
     1JPV  1K27  1ODI  1ODJ  1ODK  1SD1  1SD2  1V4N  1WTA  2A8Y  
Reference
  Authors

  Title

  Journal
  Organism
 1  [PMID:118001]
Carteni'-Farina M, Oliva A, Romeo G, Napolitano G, De Rosa M,
Gambacorta A, Zappia V.
5'-Methylthioadenosine phosphorylase from Caldariella acidophila.
Purification and properties.
Eur. J. Biochem. 101 (1979) 317-24.
Caldariella acidophila
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:415762]
Garbers DL.
Demonstration of 5'-methylthioadenosine phosphorylase activity in
various rat tissues. Some properties of the enzyme from rat lung.
Biochim. Biophys. Acta. 523 (1978) 82-93.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:5378381]
Pegg AE, Williams-Ashman HG.
Phosphate-stimulated breakdown of 5'-methylthioadenosine by rat
ventral prostate.
Biochem. J. 115 (1969) 241-7.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 2.4.2.28
IUBMB Enzyme Nomenclature: 2.4.2.28
ExPASy - ENZYME nomenclature database: 2.4.2.28
BRENDA, the Enzyme Database: 2.4.2.28
CAS: 61970-06-7
DBGET integrated database retrieval system