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Entry
EC 2.4.2.44                 Enzyme                                 

Name
S-methyl-5'-thioinosine phosphorylase;
MTIP;
MTI phosphorylase;
methylthioinosine phosphorylase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
Reaction(IUBMB)
S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate [RN:R09668]
Reaction(KEGG)
Substrate
S-methyl-5'-thioinosine [CPD:C19787];
phosphate [CPD:C00009]
Product
hypoxanthine [CPD:C00262];
S-methyl-5-thio-alpha-D-ribose 1-phosphate [CPD:C04188]
Comment
No activity with S-methyl-5'-thioadenosine. The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine [1].
History
EC 2.4.2.44 created 2011
Pathway
Cysteine and methionine metabolism
Metabolic pathways
Orthology
K19696  
5'-methylthioinosine phosphorylase
Genes
XFA: 
XFT: 
PD_1381(deoD)
XFM: 
XFN: 
XFF: 
XFL: 
XFS: 
XCC: 
XCC1285(deoD)
XCB: 
XCA: 
XCP: 
XCV: 
XCV1388(deoD)
XAC: 
XAC1336(deoD)
XCI: 
XCT: 
XCU: 
XCN: 
XCW: 
XCR: 
XCM: 
XCF: 
XCJ: 
XFU: 
XAX: 
XACM_1319(deoD)
XAO: 
XOO: 
XOO1869(deoD)
XOM: 
XOO1764(XOO1764)
XOP: 
XOY: 
XOR: 
XOZ: 
XAL: 
XSA: 
XTN: 
SML: 
SMT: 
BUJ: 
SMZ: 
SMD_3117(mtaP)
SACZ: 
PSU: 
PSUW: 
PSD: 
LAB: 
LCP: 
LGU: 
FAU: 
RHD: 
DJI: 
DJA: 
DTX: 
PAE: 
PAEV: 
N297_3110(mtnP)
PAEI: 
N296_3110(mtnP)
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PAEB: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
M802_3107(mtnP)
PAEO: 
M801_2975(mtnP)
PMY: 
PRE: 
PPSE: 
BN5_1390(mtaP)
POR: 
PST: 
PSB: 
PSYR: 
PSP: 
PCI: 
PFO: 
PMAN: 
PSA: 
PSZ: 
PSR: 
PSC: 
PSH: 
PSTU: 
PSTT: 
PBM: 
PBC: 
PPUU: 
PDR: 
PKC: 
PCH: 
PCP: 
AVN: 
AVL: 
AVD: 
ACX: 
PBB: 
MAQ: 
MHC: 
MAD: 
MBS: 
MSR: 
MSX: 
MPQ: 
MARI: 
SAGA: 
SPOI: 
MCA: 
MMT: 
MDN: 
MAH: 
MEJ: 
CYQ: 
CZA: 
TIG: 
BLEP: 
NWA: 
TVI: 
TMB: 
MPUR: 
TEE: 
AEH: 
HHA: 
HHC: 
TGR: 
TKM: 
TNI: 
TVNIR_1603(mtnP_[H])
TTI: 
TVR: 
SSAL: 
HNA: 
WMA: 
HCH: 
HCH_02681(mtaP)
ABO: 
ABO_1021(deoD)
ADI: 
B5T_01828(deoD)
APAC: 
ALN: 
TOL: 
TOR: 
OAI: 
GSN: 
TBN: 
SEDS: 
PSPI: 
 » show all
Taxonomy
Reference
1  [PMID:21197954]
  Authors
Guan R, Ho MC, Almo SC, Schramm VL
  Title
Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing.
  Journal
Biochemistry. 50 (2011) 1247-54.
  Sequence
[pae:PA3004]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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