KEGG   ENZYME: 2.4.2.44Help
Entry
EC 2.4.2.44                 Enzyme                                 

Name
S-methyl-5'-thioinosine phosphorylase;
MTIP;
MTI phosphorylase;
methylthioinosine phosphorylase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
Reaction(IUBMB)
S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate [RN:R09668]
Reaction(KEGG)
Substrate
S-methyl-5'-thioinosine [CPD:C19787];
phosphate [CPD:C00009]
Product
hypoxanthine [CPD:C00262];
S-methyl-5-thio-alpha-D-ribose 1-phosphate [CPD:C04188]
Comment
No activity with S-methyl-5'-thioadenosine. The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine [1].
History
EC 2.4.2.44 created 2011
Reference
1  [PMID:21197954]
  Authors
Guan R, Ho MC, Almo SC, Schramm VL
  Title
Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing.
  Journal
Biochemistry. 50 (2011) 1247-54.
  Organism
Pseudomonas aeruginosa
  Sequence
[up:Q9HZK1]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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