KEGG   ENZYME: 2.4.2.48Help
Entry
EC 2.4.2.48                 Enzyme                                 

Name
tRNA-guanine15 transglycosylase;
tRNA transglycosylase (ambiguous);
transfer ribonucleate glycosyltransferase (ambiguous);
tRNA guanine15 transglycosidase;
TGT (ambiguous);
transfer ribonucleic acid guanine15 transglycosylase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
tRNA-guanine15:7-cyano-7-carbaguanine tRNA-D-ribosyltransferase
Reaction(IUBMB)
guanine15 in tRNA + 7-cyano-7-carbaguanine = 7-cyano-7-carbaguanine15 in tRNA + guanine
Substrate
guanine15 in tRNA;
7-cyano-7-carbaguanine [CPD:C15996]
Product
7-cyano-7-carbaguanine15 in tRNA;
guanine [CPD:C00242]
Comment
Archaeal tRNAs contain the modified nucleoside archaeosine at position 15. This archaeal enzyme catalyses the exchange of guanine at position 15 of tRNA with the base preQ0, which is ultimately modified to form the nucleoside archaeosine (cf. EC 2.6.1.97) [1].
Reference
1  [PMID:10862614]
  Authors
Bai Y, Fox DT, Lacy JA, Van Lanen SG, Iwata-Reuyl D
  Title
Hypermodification of tRNA in Thermophilic archaea. Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii.
  Journal
J. Biol. Chem. 275 (2000) 28731-8.
  Organism
Methanocaldococcus jannaschii [GN:mja]
  Sequence
[up:Q57878]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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