KEGG   ENZYME: 2.4.99.1Help
Entry
EC 2.4.99.1                 Enzyme                                 

Name
beta-galactoside alpha-2,6-sialyltransferase;
ST6Gal-I;
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine alpha-(2->6)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine [RN:R04532 R06188]
Reaction(KEGG)
R04532 R06188(G);
(other) R05580 R05905(G) R05906(G) R05990(G) R09298(G)
Show
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
Comment
The terminal beta-D-galactosyl residue of the oligosaccharide of glycoproteins, as well as lactose, can act as acceptor.
History
EC 2.4.99.1 created 1972, modified 1976, modified 1986
Pathway
N-Glycan biosynthesis
Other types of O-glycan biosynthesis
Metabolic pathways
Orthology
K00778  
beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
K00779  
beta-galactoside alpha2,6-sialyltransferase (sialyltransferase 2)
K12248  
beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 0160)
Genes
HSA: 
6480(ST6GAL1) 84620(ST6GAL2)
PTR: 
450198(ST6GAL2) 460922(ST6GAL1)
PPS: 
100969795(ST6GAL1) 100981465(ST6GAL2)
GGO: 
101129847(ST6GAL2) 101142727(ST6GAL1)
PON: 
100174088(ST6GAL1) 100456090(ST6GAL2)
NLE: 
100580010(ST6GAL2) 100599869(ST6GAL1)
MCC: 
708113(ST6GAL1) 713552(ST6GAL2)
MCF: 
102121444(ST6GAL1) 102142751(ST6GAL2)
CJC: 
100408699(ST6GAL1) 100411939(ST6GAL2)
MMU: 
20440(St6gal1) 240119(St6gal2)
RNO: 
25197(St6gal1) 301155(St6gal2)
CGE: 
100689389(St6gal1) 100763756(St6gal2)
NGI: 
103726632(St6gal2) 103750114(St6gal1)
HGL: 
101718025(St6gal1) 101722644(St6gal2)
OCU: 
100353188(ST6GAL1) 100358153(ST6GAL2)
TUP: 
102499508(ST6GAL1) 102500330(ST6GAL2)
CFA: 
478668(ST6GAL1) 481315(ST6GAL2)
AML: 
UMR: 
103670658(ST6GAL2) 103676045(ST6GAL1)
FCA: 
101097832(ST6GAL1) 101098620(ST6GAL2)
PTG: 
102956769(ST6GAL1) 102962032(ST6GAL2)
BTA: 
282073(ST6GAL1) 493992(ST6GAL2)
BOM: 
102273022(ST6GAL1) 102281174 102285977(ST6GAL2)
PHD: 
102334395(ST6GAL1) 102334543(ST6GAL2)
CHX: 
100861310(ST6GAL1) 102179776(ST6GAL2)
OAS: 
100913159(ST6GAL1) 101108300(ST6GAL2)
SSC: 
CFR: 
102508797(ST6GAL2) 102512873(ST6GAL1)
BACU: 
103009068(ST6GAL2) 103012200(ST6GAL1)
LVE: 
103073782(ST6GAL2) 103086030(ST6GAL1)
ECB: 
100059539(ST6GAL1) 100062033(ST6GAL2)
MYB: 
MYD: 
102753980(ST6GAL1) 102768324(ST6GAL2)
PALE: 
102886717(ST6GAL1) 102890603(ST6GAL2)
MDO: 
100019249(ST6GAL2) 100617174(ST6GAL1)
SHR: 
100922140(ST6GAL1) 100932183(ST6GAL2)
OAA: 
GGA: 
396169(ST6GAL1) 403122(ST6GAL2)
MGP: 
APLA: 
TGU: 
100226346(ST6GAL1) 100230425(ST6GAL2)
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
100529108(st6gal2) 100529109(st6gal1)
PBI: 
XTR: 
100491268(st6gal1) 407846(st6gal2)
DRE: 
403116(st6gal2a) 445376(st6gal1)
TRU: 
445982(siat1) 777969(st6gal2)
MZE: 
OLA: 
100049381(siat2)
XMA: 
LCM: 
CMK: 
103172241(st6gal2) 103174913(st6gal1)
BFO: 
DME: 
Dmel_CG4871(ST6Gal)
DPO: 
Dpse_GA18492(Dpse_ST6Gal)
DAN: 
Dana_GF11909(Dana_ST6Gal)
DER: 
Dere_GG19899(Dere_ST6Gal)
DPE: 
Dper_GL17166(Dper_ST6Gal)
DSE: 
Dsec_GM11799(Dsec_ST6Gal)
DSI: 
Dsim_GD24925(Dsim_ST6Gal)
DWI: 
DYA: 
Dyak_GE11423(Dyak_ST6Gal)
DGR: 
Dgri_GH21565(Dgri_ST6Gal)
DMO: 
Dmoj_GI19537(Dmoj_ST6Gal)
DVI: 
Dvir_GJ21108(Dvir_ST6Gal)
MDE: 
BMOR: 
PHU: 
ISC: 
HDU: 
PMU: 
SWP: 
 » show all
Taxonomy
Reference
1  [PMID:4723915]
  Authors
Bartholomew BA, Jourdian GW, Roseman S.
  Title
The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum.
  Journal
J. Biol. Chem. 248 (1973) 5751-62.
Reference
2  [PMID:4313609]
  Authors
Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH.
  Title
Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin.
  Journal
J. Biol. Chem. 245 (1970) 759-66.
Reference
3  [PMID:849932]
  Authors
Paulson JC, Beranek WE, Hill RL.
  Title
Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose.
  Journal
J. Biol. Chem. 252 (1977) 2356-62.
Reference
4  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods. Enzymol. 98 (1983) 98-134.
Reference
5  [PMID:5726897]
  Authors
Spiro MJ, Spiro RG.
  Title
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid sialyltransferase.
  Journal
J. Biol. Chem. 243 (1968) 6520-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9075-81-4

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