KEGG   ENZYME: 2.4.99.10Help
Entry
EC 2.4.99.10                Enzyme                                 

Name
neolactotetraosylceramide alpha-2,3-sialyltransferase;
sialyltransferase;
cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase;
sialyltransferase 3;
SAT-3;
CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl(1<->1)ceramide alpha-(2->3)-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide alpha-(2->3)-sialyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide [RN:R04656 R06026]
Reaction(KEGG)
R04656 R06026(G);
(other) R06037(G)
Show
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide
History
EC 2.4.99.10 created 1986
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K03792  
beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 10)
Genes
HSA: 
10402(ST3GAL6)
PTR: 
460547(ST3GAL6)
PPS: 
100977718(ST3GAL6)
GGO: 
101133620(ST3GAL6)
PON: 
100171770(ST3GAL6)
MCC: 
699096(ST3GAL6)
MCF: 
102115716(ST3GAL6)
MMU: 
54613(St3gal6)
RNO: 
304023(St3gal6)
CGE: 
100771326(St3gal6)
HGL: 
101706310(St3gal6)
TUP: 
102481523(ST3GAL6)
CFA: 
478535(ST3GAL6)
AML: 
FCA: 
101091552(ST3GAL6)
PTG: 
102952023(ST3GAL6)
BTA: 
444860(ST3GAL6)
BOM: 
102265994(ST3GAL6)
PHD: 
102337048(ST3GAL6)
CHX: 
102175162(ST3GAL6)
OAS: 
101106812(ST3GAL6)
SSC: 
100739492(ST3GAL6)
CFR: 
102516778(ST3GAL6)
BACU: 
103001584(ST3GAL6)
LVE: 
103078993(ST3GAL6)
ECB: 
100062218(ST3GAL6)
MYB: 
102260204(ST3GAL6)
MYD: 
102754272(ST3GAL6)
PALE: 
102889744(ST3GAL6)
MDO: 
100017812(ST3GAL6)
SHR: 
100923762(ST3GAL6)
OAA: 
GGA: 
395138(ST3GAL6)
MGP: 
TGU: 
100222736(ST3GAL6)
FAB: 
101815960(ST3GAL6)
PHI: 
102099818(ST3GAL6)
APLA: 
101802079(ST3GAL6)
FPG: 
101915399(ST3GAL6)
FCH: 
102060181(ST3GAL6)
CLV: 
102083691(ST3GAL6)
ASN: 
102377903(ST3GAL6)
AMJ: 
PSS: 
102462369(ST3GAL6)
CMY: 
102947450(ST3GAL6)
ACS: 
100557291(st3gal6)
PBI: 
103051166(ST3GAL6)
XLA: 
398745(st3gal6)
XTR: 
402790(st3gal6)
LCM: 
CMK: 
103180110(st3gal6)
SPU: 
 » show all
Taxonomy
Reference
1  [PMID:7130178]
  Authors
Basu M, Basu S, Stoffyn A, Stoffyn P.
  Title
Biosynthesis in vitro of sialyl(alpha 2-3)neolactotetraosylceramide by a sialyltransferase from embryonic chicken brain.
  Journal
J. Biol. Chem. 257 (1982) 12765-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
83745-06-6

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