KEGG   ENZYME: 2.4.99.3Help
Entry
EC 2.4.99.3                 Enzyme                                 
Name
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein [RN:R05911]
Reaction(KEGG)
R05911(G) > R05914(G) R06273(G)
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Substrate
CMP-N-acetylneuraminate [CPD:C00128];
glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
Product
CMP [CPD:C00055];
glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
Comment
alpha-N-Acetylgalactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.
Pathway
Mucin type O-Glycan biosynthesis
Metabolic pathways
Orthology
K03479  
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A)
Genes
HSA: 
55808(ST6GALNAC1)
PTR: 
449516(ST6GALNAC1)
PPS: 
100990954(ST6GALNAC1)
GGO: 
101131564(ST6GALNAC1)
PON: 
100437242(ST6GALNAC1)
MCC: 
707339(ST6GALNAC1)
MMU: 
20445(St6galnac1)
RNO: 
287920(St6galnac1)
CFA: 
100049002(ST6GALNAC1)
AML: 
FCA: 
101085418(ST6GALNAC1)
BTA: 
618655(ST6GALNAC1)
SSC: 
100622490(ST6GALNAC1)
ECB: 
100058687(ST6GALNAC1)
SHR: 
100913684(ST6GALNAC1)
OAA: 
100076453
GGA: 
396168(ST6GALNAC1)
MGP: 
100549131
TGU: 
100227473(ST6GALNAC1)
ACS: 
100552576
DRE: 
564336(st6galnac1.1)
OLA: 
101164026
 » show all
Taxonomy
Reference
1  [PMID:447688]
  Authors
Sadler JE, Rearick JI, Hill RL.
  Title
Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands.
  Journal
J. Biol. Chem. 254 (1979) 5934-41.
  Organism
Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
71124-50-0
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