| Entry |
|
|---|
| Name |
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
 |
|---|
| Sysname |
CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl
)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase |
|---|
| Reaction(IUBMB) |
CMP-N-acetylneuraminate +
glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP
+
glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-
galactosaminyl)-glycoprotein [RN:R05911] |
|---|
| Reaction(KEGG) |
R05911(G) > R05914(G) R06273(G)
 |
|---|
| Substrate |
CMP-N-acetylneuraminate [CPD:C00128];
glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein |
|---|
| Product |
CMP [CPD:C00055];
glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-
galactosaminyl)-glycoprotein |
|---|
| Comment |
alpha-N-Acetylgalactosamine linked to threonine or serine is also an
acceptor, when substituted at the 3-position. |
|---|
| Pathway |
PATH: ec00512 O-Glycan biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K03479 alpha-N-acetylgalactosaminide
alpha-2,6-sialyltransferase (sialyltransferase 7A) |
|---|
| Genes |
HSA: 55808(ST6GALNAC1)
PTR: 449516(ST6GALNAC1)
MCC: 707339(ST6GALNAC1)
MMU: 20445(St6galnac1) 675562
RNO: 287920(St6galnac1)
CFA: 100049002(ST6GALNAC1) 483334(ST6GALNAC1)
BTA: 618655(ST6GALNAC1)
ECB: 100058687
OAA: 100076453
GGA: 396168(ST6GALNAC1)
DRE: 564336
SPU: 580149
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:447688]
Sadler JE, Rearick JI, Hill RL.
Purification to homogeneity and enzymatic characterization of an
alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase
from porcine submaxillary glands.
J. Biol. Chem. 254 (1979) 5934-41.
Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.99.3
IUBMB Enzyme Nomenclature: 2.4.99.3
ExPASy - ENZYME nomenclature database: 2.4.99.3
BRENDA, the Enzyme Database: 2.4.99.3
CAS: 71124-50-0 |
|---|
