KEGG   ENZYME: 2.4.99.5Help
Entry
EC 2.4.99.5                 Enzyme                                 

Name
galactosyldiacylglycerol alpha-2,3-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetyl-beta-neuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetyl-beta-neuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol = CMP + 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol [RN:R03468]
Reaction(KEGG)
Substrate
CMP-N-acetyl-beta-neuraminate [CPD:C00128];
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol [CPD:C03692]
Product
CMP [CPD:C00055];
1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol
Comment
The beta-D-galactosyl residue of the oligosaccharide of glycoproteins may also act as acceptor.
History
EC 2.4.99.5 created 1984, modified 1986
Pathway
Glycerolipid metabolism
Reference
1  [PMID:7298658]
  Authors
Pieringer J, Keech S, Pieringer RA.
  Title
Biosynthesis in vitro of sialosylgalactosyldiacylglycerol by mouse brain microsomes.
  Journal
J. Biol. Chem. 256 (1981) 12306-9.
Reference
2  [PMID:7142179]
  Authors
Weinstein J, de Souza-e-Silva U, Paulson JC.
  Title
Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver.
  Journal
J. Biol. Chem. 257 (1982) 13835-44.
Reference
3  [PMID:7142180]
  Authors
Weinstein J, de Souza-e-Silva U, Paulson JC.
  Title
Sialylation of glycoprotein oligosaccharides N-linked to asparagine. Enzymatic characterization of a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase and a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase from rat liver.
  Journal
J. Biol. Chem. 257 (1982) 13845-53.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
80237-98-5

DBGET integrated database retrieval system