| Entry |
|
|---|
| Name |
N-acetyllactosaminide alpha-2,3-sialyltransferase;
sialyltransferase;
cytidine
monophosphoacetylneuraminate-beta-galactosyl(1-
>4)acetylglucosaminide alpha2->3-sialyltransferase;
alpha2->3 sialyltransferase;
SiaT;
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-
glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
 |
|---|
| Sysname |
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosam
inyl-glycoprotein alpha-(2->3)-N-acetylneuraminyltransferase |
|---|
| Reaction(IUBMB) |
CMP-N-acetylneuraminate +
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein = CMP
+
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-
glucosaminyl-glycoprotein [RN:R04596] |
|---|
| Reaction(KEGG) |
R04596;
(other) R06153(G)
 |
|---|
| Substrate |
CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein |
|---|
| Product |
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-
glucosaminyl-glycoprotein |
|---|
| Comment |
Acts on beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl termini on
glycoprotein. |
|---|
| Pathway |
PATH: ec00533 Keratan sulfate biosynthesis
PATH: ec00601 Glycosphingolipid biosynthesis - lacto and neolacto
series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00781 N-acetyllactosaminide alpha-2,3-sialyltransferase
(sialyltransferase 6) |
|---|
| Genes |
HSA: 6487(ST3GAL3)
PTR: 456832(ST3GAL3)
MCC: 703599(ST3GAL3)
MMU: 20441(St3gal3)
RNO: 64445(St3gal3)
CFA: 610736(ST3GAL3)
BTA: 444859(ST3GAL3)
SSC: 396619(ST3GAL3)
ECB: 100053104
MDO: 100025401
OAA: 100078221
GGA: 424572(ST3GAL3)
TGU: 100221242
XLA: 398746(st3Gal-III)
XTR: 402789(siat6)
DRE: 407659(st3gal3l)
SPU: 581680
 |
|---|
| Structures |
PDB: 2EX0 2EX1 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:7204397]
Van den Eijnden DH, Schiphorst WE.
Detection of beta-galactosyl(1 leads to 4)N-acetylglucosaminide
alpha(2 leads to 3)-sialyltransferase activity in fetal calf liver
and other tissues.
J. Biol. Chem. 256 (1981) 3159-62.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.99.6
IUBMB Enzyme Nomenclature: 2.4.99.6
ExPASy - ENZYME nomenclature database: 2.4.99.6
BRENDA, the Enzyme Database: 2.4.99.6
CAS: 77537-85-0 |
|---|
