KEGG   ENZYME: 2.4.99.6Help
Entry
EC 2.4.99.6                 Enzyme                                 

Name
N-acetyllactosaminide alpha-2,3-sialyltransferase;
sialyltransferase;
cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase;
alpha2->3 sialyltransferase;
SiaT;
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein alpha-(2->3)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein [RN:R04596 R09297]
Reaction(KEGG)
R04596 R09297(G);
(other) R06153(G)
Show
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein
Comment
Acts on beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl termini on glycoprotein.
History
EC 2.4.99.6 created 1984, modified 1986
Pathway
Various types of N-glycan biosynthesis
Other types of O-glycan biosynthesis
Glycosaminoglycan biosynthesis - keratan sulfate
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K00781  
N-acetyllactosaminide alpha-2,3-sialyltransferase (sialyltransferase 6)
Genes
HSA: 
6487(ST3GAL3)
PTR: 
456832(ST3GAL3)
PPS: 
100982060(ST3GAL3)
GGO: 
101126091(ST3GAL3)
PON: 
NLE: 
100596717(ST3GAL3)
MCC: 
703599(ST3GAL3)
MCF: 
102124772(ST3GAL3)
CJC: 
100411797(ST3GAL3)
MMU: 
20441(St3gal3)
RNO: 
64445(St3gal3)
CGE: 
100689187(St3gal3)
NGI: 
103743864(St3gal3)
HGL: 
101716398(St3gal3)
OCU: 
100353106(ST3GAL3)
TUP: 
102486753(ST3GAL3)
CFA: 
610736(ST3GAL3)
AML: 
100472631(ST3GAL3)
UMR: 
103670807(ST3GAL3)
FCA: 
101081911(ST3GAL3)
PTG: 
102966623(ST3GAL3)
BTA: 
444859(ST3GAL3)
BOM: 
102284552(ST3GAL3)
PHD: 
102343639(ST3GAL3)
CHX: 
102168794(ST3GAL3)
OAS: 
101112269(ST3GAL3)
SSC: 
396619(ST3GAL3)
CFR: 
102517093(ST3GAL3)
BACU: 
103003034(ST3GAL3)
LVE: 
103083644(ST3GAL3)
ECB: 
100053104(ST3GAL3)
MYB: 
102245915(ST3GAL3)
MYD: 
102773348(ST3GAL3)
PALE: 
102883140(ST3GAL3)
MDO: 
100025401(ST3GAL3)
SHR: 
100917951(ST3GAL3)
OAA: 
GGA: 
424572(ST3GAL3)
MGP: 
100543009(ST3GAL3)
APLA: 
101804175(ST3GAL3)
TGU: 
100221242(ST3GAL3)
FAB: 
101807588(ST3GAL3)
PHI: 
102104267(ST3GAL3)
FPG: 
101917466(ST3GAL3)
FCH: 
102055195(ST3GAL3)
CLV: 
102089431(ST3GAL3)
ASN: 
102387225(ST3GAL3)
AMJ: 
102570899(ST3GAL3)
PSS: 
CMY: 
102937505(ST3GAL3)
ACS: 
100556902(st3gal3)
PBI: 
103048808(ST3GAL3)
XLA: 
100462908(st3gal-iii) 398746(st3gal3)
XTR: 
402789(st3gal3)
DRE: 
407659(st3gal3b)
TRU: 
445973(siat6)
MZE: 
OLA: 
100049527(siat6)
XMA: 
LCM: 
102351151(ST3GAL3)
CMK: 
103174609(st3gal3)
BFO: 
 » show all
Taxonomy
Reference
1  [PMID:7204397]
  Authors
Van den Eijnden DH, Schiphorst WE.
  Title
Detection of beta-galactosyl(1 leads to 4)N-acetylglucosaminide alpha(2 leads to 3)-sialyltransferase activity in fetal calf liver and other tissues.
  Journal
J. Biol. Chem. 256 (1981) 3159-62.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
77537-85-0

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