KEGG   ENZYME: 2.4.99.7Help
Entry
EC 2.4.99.7                 Enzyme                                 
Name
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase;
sialyltransferase;
cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase;
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase;
SIAT7;
ST6GALNAC;
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase;
CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [RN:R04635]
Reaction(KEGG)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R [CPD:C04885]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [CPD:C04926]
Comment
Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-galactosamine only when present in the structure of alpha-N-acetyl-neuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.99.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.
Pathway
Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
Orthology
K03374  
N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7D)
Genes
HSA: 
27090(ST6GALNAC4)
PTR: 
450108(ST6GALNAC4)
PPS: 
100995780(ST6GALNAC4)
GGO: 
101151595(ST6GALNAC4)
PON: 
100439613(ST6GALNAC4)
MCC: 
705879(ST6GALNAC4)
MMU: 
20448(St6galnac4)
RNO: 
407764(siat7D)
CFA: 
609133(ST6GALNAC4)
AML: 
FCA: 
101094459(ST6GALNAC4)
BTA: 
404124(ST6GALNAC4)
SSC: 
396676(ST6GALNAC2)
ECB: 
100067121
MDO: 
100012077
SHR: 
100921479(ST6GALNAC4)
OAA: 
100078837
GGA: 
395182(ST6GALNAC4)
MGP: 
100543224
TGU: 
100232134(ST6GALNAC4)
ACS: 
100552238
XTR: 
779760(st6galnac4)
DRE: 
751653(st6galnac4)
SPU: 
574822
NVE: 
NEMVE_v1g104549
 » show all
Taxonomy
Reference
1  [PMID:6190802]
  Authors
Bergh ML, Hooghwinkel GJ, van den Eijnden DH.
  Title
Biosynthesis of the O-glycosidically linked oligosaccharide chains of fetuin. Indications for an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase with a narrow acceptor specificity in fetal calf liver.
  Journal
J. Biol. Chem. 258 (1983) 7430-6.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
129924-24-9
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