| Entry |
|
|---|
| Name |
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-
acetylgalactosaminide 6-alpha-sialyltransferase;
sialyltransferase;
cytidine
monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-
galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase;
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-
galactosaminide alpha-2,6-sialyltransferase;
SIAT7;
ST6GALNAC;
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-
galactosaminide 6-alpha-sialyltransferase;
CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-
galactosyl-1,3)-N-acetyl-D-galactosaminide
alpha-2,6-N-acetylneuraminyl-transferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
 |
|---|
| Sysname |
CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-gala
ctosyl-(1->3)- N-acetyl-D-galactosaminide
galactosamine-6-alpha-N-acetylneuraminyltransferase |
|---|
| Reaction(IUBMB) |
CMP-N-acetylneuraminate +
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-
D-galactosaminyl-R = CMP +
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-
alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [RN:R04635] |
|---|
| Reaction(KEGG) |
R04635
 |
|---|
| Substrate |
CMP-N-acetylneuraminate [CPD:C00128];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-
D-galactosaminyl-R [CPD:C04885] |
|---|
| Product |
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-
alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [CPD:C04926] |
|---|
| Comment |
Attaches N-acetylneuraminic acid in alpha-2,6-linkage to
N-acetyl-galactosamine only when present in the structure of
alpha-N-acetyl-neuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgala
ctosaminyl-R, where R may be protein or p-nitrophenol. Not identical
with EC 2.4.99.3 alpha-N-acetylgalactosaminide
alpha-2,6-sialyltransferase. |
|---|
| Pathway |
PATH: ec00604 Glycosphingolipid biosynthesis - ganglio series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K03374 N-acetylgalactosaminide alpha-2,6-sialyltransferase
(sialyltransferase 7D) |
|---|
| Genes |
HSA: 27090(ST6GALNAC4)
PTR: 450108(ST6GALNAC4)
MCC: 705879(ST6GALNAC4)
MMU: 20448(St6galnac4)
RNO: 407764(siat7D)
CFA: 609133(ST6GALNAC4)
BTA: 404124(ST6GALNAC2)
SSC: 396676(ST6GALNAC2)
ECB: 100067121
MDO: 100012077
OAA: 100078837
GGA: 395182(ST6GALNAC4)
TGU: 100232134
XTR: 779760(st6galnac4)
DRE: 751653(st6galnac4)
SPU: 574822
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6190802]
Bergh ML, Hooghwinkel GJ, van den Eijnden DH.
Biosynthesis of the O-glycosidically linked oligosaccharide chains
of fetuin. Indications for an alpha-N-acetylgalactosaminide alpha 2
leads to 6 sialyltransferase with a narrow acceptor specificity in
fetal calf liver.
J. Biol. Chem. 258 (1983) 7430-6.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.99.7
IUBMB Enzyme Nomenclature: 2.4.99.7
ExPASy - ENZYME nomenclature database: 2.4.99.7
BRENDA, the Enzyme Database: 2.4.99.7
CAS: 129924-24-9 |
|---|
