KEGG   ENZYME: 2.4.99.7Help
Entry
EC 2.4.99.7                 Enzyme                                 

Name
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase;
sialyltransferase;
cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase;
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase;
SIAT7;
ST6GALNAC;
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase;
CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [RN:R04635]
Reaction(KEGG)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R [CPD:C04885]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [CPD:C04926]
Comment
Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-galactosamine only when present in the structure of alpha-N-acetyl-neuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.99.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.
History
EC 2.4.99.7 created 1984, modified 1986, modified 2004
Pathway
Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
Orthology
K03374  
N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7D)
Genes
HSA: 
27090(ST6GALNAC4)
PTR: 
450108(ST6GALNAC4)
PPS: 
100995780(ST6GALNAC4)
GGO: 
101151595(ST6GALNAC4)
PON: 
100439613(ST6GALNAC4)
NLE: 
100598104(ST6GALNAC4)
MCC: 
705879(ST6GALNAC4)
MCF: 
102142909(ST6GALNAC4)
CJC: 
100401438(ST6GALNAC4)
MMU: 
20448(St6galnac4)
RNO: 
407764(St6galnac4)
CGE: 
100759065(St6galnac4)
HGL: 
101717187(St6galnac4)
TUP: 
102487439(ST6GALNAC4)
CFA: 
609133(ST6GALNAC4)
AML: 
FCA: 
101094459(ST6GALNAC4)
PTG: 
102966320(ST6GALNAC4)
BTA: 
404124(ST6GALNAC4)
BOM: 
102287870(ST6GALNAC4)
PHD: 
102344910(ST6GALNAC4)
CHX: 
102170329(ST6GALNAC4)
OAS: 
101123019(ST6GALNAC4)
SSC: 
396676(ST6GALNAC2)
CFR: 
102503832(ST6GALNAC4)
BACU: 
103005340(ST6GALNAC4)
LVE: 
103086160(ST6GALNAC4)
ECB: 
100067121(ST6GALNAC4)
MYB: 
102261251(ST6GALNAC4)
MYD: 
102754268(ST6GALNAC4)
PALE: 
102881827(ST6GALNAC4)
MDO: 
100012077(ST6GALNAC4)
SHR: 
100921479(ST6GALNAC4)
OAA: 
100078837(ST6GALNAC4)
GGA: 
395182(ST6GALNAC4)
MGP: 
TGU: 
100232134(ST6GALNAC4)
FAB: 
101817162(ST6GALNAC4)
PHI: 
102109129(ST6GALNAC4)
FPG: 
101923804(ST6GALNAC4)
FCH: 
102056501(ST6GALNAC4)
CLV: 
102090323(ST6GALNAC4)
ASN: 
102385694(ST6GALNAC4)
AMJ: 
102575154(ST6GALNAC4)
PSS: 
102443948(ST6GALNAC4)
CMY: 
102932867(ST6GALNAC4)
ACS: 
100552238(st6galnac4)
PBI: 
103063354(ST6GALNAC4)
XTR: 
779760(st6galnac4)
DRE: 
751653(st6galnac4)
LCM: 
102363654(ST6GALNAC4)
SPU: 
NVE: 
 » show all
Taxonomy
Reference
1  [PMID:6190802]
  Authors
Bergh ML, Hooghwinkel GJ, van den Eijnden DH.
  Title
Biosynthesis of the O-glycosidically linked oligosaccharide chains of fetuin. Indications for an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase with a narrow acceptor specificity in fetal calf liver.
  Journal
J. Biol. Chem. 258 (1983) 7430-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
129924-24-9

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