| Entry |
|
|---|
| Name |
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase;
cytidine monophosphoacetylneuraminate-ganglioside GM3;
alpha-2,8-sialyltransferase;
ganglioside GD3 synthase;
ganglioside GD3 synthetase sialyltransferase;
CMP-NeuAc:LM1(alpha2-8) sialyltranferase;
GD3 synthase;
SAT-2 |
|---|
| Class |
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
 |
|---|
| Sysname |
CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-(2->3)-beta-D-galac
toside alpha-(2->8)-N-acetylneuraminyltransferase |
|---|
| Reaction(IUBMB) |
CMP-N-acetylneuraminate +
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP +
alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-
beta-D-galactosyl-R [RN:R04564] |
|---|
| Reaction(KEGG) |
R04564 > R04583 R05940(G) R06032(G);
(other) R04632 R04649 R04661 R05113 R05995(G) R06000(G) R06005(G)
R06009(G)
 |
|---|
| Substrate |
CMP-N-acetylneuraminate [CPD:C00128];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R |
|---|
| Product |
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-
beta-D-galactosyl-R |
|---|
| Comment |
Gangliosides act as acceptors. |
|---|
| Pathway |
PATH: ec00601 Glycosphingolipid biosynthesis - lacto and neolacto
series
PATH: ec00603 Glycosphingolipid biosynthesis - globo series
PATH: ec00604 Glycosphingolipid biosynthesis - ganglio series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K03371 alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase
(sialyltransferase 8A) |
|---|
| Genes |
HSA: 6489(ST8SIA1)
PTR: 465341(ST8SIA1)
MCC: 706707(ST8SIA1)
MMU: 20449(St8sia1)
RNO: 25280(St8sia1)
CFA: 477672(ST8SIA1)
BTA: 282352(ST8SIA1)
MDO: 100011205
OAA: 100080234
GGA: 395860(ST8SIA1)
TGU: 100225976
XLA: 398735(st8sia1)
XTR: 444887(st8siaI)
DRE: 553210(st8sia1)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:7407217]
Eppler CM, Morre DJ, Keenan TW.
Ganglioside biosynthesis in rat liver: alteration of
sialyltransferase activities by nucleotides.
Biochim. Biophys. Acta. 619 (1980) 332-43.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3838172]
Higashi H, Basu M, Basu S.
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a
solubilized sialyltransferase from embryonic chicken brain.
J. Biol. Chem. 260 (1985) 824-8.
Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4044605]
McCoy RD, Vimr ER, Troy FA.
CMP-NeuNAc:poly-alpha-2,8-sialosyl sialyltransferase and the
biosynthesis of polysialosyl units in neural cell adhesion
molecules.
J. Biol. Chem. 260 (1985) 12695-9.
Rattus norvegicus [GN:rno], Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:6766128]
Yohe HC, Yu RK.
In vitro biosynthesis of an isomer of brain trisialoganglioside,
GT1a.
J. Biol. Chem. 255 (1980) 608-13.
Gallus gallus [GN:gga] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.99.8
IUBMB Enzyme Nomenclature: 2.4.99.8
ExPASy - ENZYME nomenclature database: 2.4.99.8
BRENDA, the Enzyme Database: 2.4.99.8
CAS: 67339-00-8 |
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