KEGG   ENZYME: 2.4.99.8Help
Entry
EC 2.4.99.8                 Enzyme                                 

Name
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase;
cytidine monophosphoacetylneuraminate-ganglioside GM3;
alpha-2,8-sialyltransferase;
ganglioside GD3 synthase;
ganglioside GD3 synthetase sialyltransferase;
CMP-NeuAc:LM1(alpha2-8) sialyltranferase;
GD3 synthase;
SAT-2
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactoside alpha-(2->8)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R [RN:R04564]
Reaction(KEGG)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Comment
Gangliosides act as acceptors.
History
EC 2.4.99.8 created 1984, modified 1986
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - globo series
Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
Orthology
K03371  
alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
Genes
HSA: 
6489(ST8SIA1)
PTR: 
465341(ST8SIA1)
PPS: 
100970748(ST8SIA1)
GGO: 
101134419(ST8SIA1)
PON: 
MCC: 
706707(ST8SIA1)
MCF: 
102118571(ST8SIA1)
MMU: 
20449(St8sia1)
RNO: 
25280(St8sia1)
CGE: 
100768920(St8sia1)
HGL: 
101696963(St8sia1)
TUP: 
102468919(ST8SIA1)
CFA: 
477672(ST8SIA1)
AML: 
100464397(ST8SIA1)
FCA: 
101093029(ST8SIA1)
PTG: 
102962819(ST8SIA1)
BTA: 
282352(ST8SIA1)
BOM: 
PHD: 
102334137(ST8SIA1)
CHX: 
SSC: 
100621251(ST8SIA1)
CFR: 
102512853(ST8SIA1)
BACU: 
103009301(ST8SIA1)
LVE: 
103076775(ST8SIA1)
ECB: 
100064415(ST8SIA1)
MYB: 
102249041(ST8SIA1)
MYD: 
PALE: 
102892181(ST8SIA1)
MDO: 
100011205(ST8SIA1)
SHR: 
100920916(ST8SIA1)
OAA: 
GGA: 
395860(ST8SIA1)
MGP: 
TGU: 
100225976(ST8SIA1)
FAB: 
101806998(ST8SIA1)
PHI: 
102111773(ST8SIA1)
APLA: 
101797310(ST8SIA1)
FPG: 
101922614(ST8SIA1)
FCH: 
102056471(ST8SIA1)
CLV: 
102093502(ST8SIA1)
ASN: 
102378302(ST8SIA1)
AMJ: 
PSS: 
102462829(ST8SIA1)
CMY: 
102943965(ST8SIA1)
ACS: 
100337536(siat8a)
PBI: 
103065178(ST8SIA1)
XLA: 
398735(st8sia1)
XTR: 
444887(st8sia1)
DRE: 
100333872 553210(st8sia1)
TRU: 
445978(siat_8A)
MZE: 
OLA: 
100049518(siat8a)
XMA: 
LCM: 
102350065(ST8SIA1)
CMK: 
103181078(st8sia1)
BFO: 
 » show all
Taxonomy
Reference
1  [PMID:7407217]
  Authors
Eppler CM, Morre DJ, Keenan TW.
  Title
Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides.
  Journal
Biochim. Biophys. Acta. 619 (1980) 332-43.
  Organism
Rattus norvegicus
Reference
2  [PMID:3838172]
  Authors
Higashi H, Basu M, Basu S.
  Title
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.
  Journal
J. Biol. Chem. 260 (1985) 824-8.
  Organism
Gallus gallus
Reference
3  [PMID:4044605]
  Authors
McCoy RD, Vimr ER, Troy FA.
  Title
CMP-NeuNAc:poly-alpha-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules.
  Journal
J. Biol. Chem. 260 (1985) 12695-9.
  Organism
Rattus norvegicus, Gallus gallus
Reference
4  [PMID:6766128]
  Authors
Yohe HC, Yu RK.
  Title
In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a.
  Journal
J. Biol. Chem. 255 (1980) 608-13.
  Organism
Gallus gallus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
67339-00-8

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