KEGG   ENZYME: 2.5.1.2Help
Entry
EC 2.5.1.2                  Enzyme                                 

Name
thiamine pyridinylase;
pyrimidine transferase;
thiaminase I;
thiamin hydrolase;
thiamin pyridinolase;
thiaminase;
thiamine pyridinolase;
thiamin pyridinylase;
thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Reaction(IUBMB)
thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole [RN:R02863]
Reaction(KEGG)
Substrate
thiamine [CPD:C00378];
pyridine [CPD:C00747]
Product
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium [CPD:C02691];
4-methyl-5-(2-hydroxyethyl)thiazole
Comment
Various bases and thiol compounds can act instead of pyridine.
History
EC 2.5.1.2 created 1961, modified 1976, modified 2001
Pathway
Thiamine metabolism
Orthology
K10811  
thiamine pyridinylase
Genes
BPS: 
BPM: 
BPL: 
BPD: 
BTE: 
BGL: 
CBO: 
CBA: 
CBH: 
CBY: 
CBL: 
CBB: 
CBI: 
CBF: 
MED: 
CYC: 
 » show all
Taxonomy
Reference
1  [PMID:13158184]
  Authors
FUJITA A.
  Title
Thiaminase.
  Journal
Adv. Enzymol. Relat. Subj. Biochem. 15 (1954) 389-421.
Reference
2  [PMID:13471505]
  Authors
KENTEN RH.
  Title
[Pteridium aquilinum (L.) Kuhn.]
  Journal
Biochem. J. 67 (1957) 25-33.
Reference
3  [PMID:4966932]
  Authors
Wittliff JL, Airth RL.
  Title
The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties.
  Journal
Biochemistry. 7 (1968) 736-44.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-35-7

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