| Entry |
|
|---|
| Name |
thiamine pyridinylase;
pyrimidine transferase;
thiaminase I;
thiamin hydrolase;
thiamin pyridinolase;
thiaminase;
thiamine pyridinolase;
thiamin pyridinylase;
thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase |
|---|
| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only
sub-subclass identified to date)
 |
|---|
| Sysname |
thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase |
|---|
| Reaction(IUBMB) |
thiamine + pyridine =
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium +
4-methyl-5-(2-hydroxyethyl)thiazole [RN:R02863] |
|---|
| Reaction(KEGG) |
R02863
 |
|---|
| Substrate |
thiamine [CPD:C00378];
pyridine [CPD:C00747] |
|---|
| Product |
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium;
4-methyl-5-(2-hydroxyethyl)thiazole |
|---|
| Comment |
Various bases and thiol compounds can act instead of pyridine. |
|---|
| Pathway |
PATH: ec00730 Thiamine metabolism |
|---|
| Orthology |
KO: K10811 thiamine pyridinylase |
|---|
| Genes |
BPS: BPSS1103
BPM: BURPS1710b_A0059
BPL: BURPS1106A_A1472
BPD: BURPS668_A1560
BTE: BTH_II1306
CBO: CBO0770
CBA: CLB_0812
CBH: CLC_0826
CBY: CLM_0920
CBL: CLK_0178
CBB: CLD_3794
CBI: CLJ_B0819
CBF: CLI_0856
CYC: PCC7424_0400
 |
|---|
| Structures |
PDB: 2GM7 2GM8 2THI 3THI 4THI |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:13158184]
FUJITA A.
Thiaminase.
Adv. Enzymol. Relat. Subj. Biochem. 15 (1954) 389-421. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13471505]
KENTEN RH.
[Pteridium aquilinum (L.) Kuhn.]
Biochem. J. 67 (1957) 25-33.
Pteridium aquilinum |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4966932]
Wittliff JL, Airth RL.
The extracellular thiaminase I of Bacillus thiaminolyticus. I.
Purification and physicochemical properties.
Biochemistry. 7 (1968) 736-44.
Bacillus thiaminolyticus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.5.1.2
IUBMB Enzyme Nomenclature: 2.5.1.2
ExPASy - ENZYME nomenclature database: 2.5.1.2
BRENDA, the Enzyme Database: 2.5.1.2
CAS: 9030-35-7 |
|---|
