KEGG   ENZYME: 2.5.1.22Help
Entry
EC 2.5.1.22                 Enzyme                                 

Name
spermine synthase;
spermidine aminopropyltransferase;
spermine synthetase;
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase
Reaction(IUBMB)
S-adenosyl 3-(methylthio)propylamine + spermidine = S-methyl-5'-thioadenosine + spermine [RN:R02869]
Reaction(KEGG)
Substrate
S-adenosyl 3-(methylthio)propylamine [CPD:C01137];
spermidine [CPD:C00315]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
spermine [CPD:C00750]
Comment
The enzyme from mammalia is highly specific for spermidine [2,3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.23 (sym-norspermidine synthase).
History
EC 2.5.1.22 created 1982, modified 2013
Pathway
Cysteine and methionine metabolism
Arginine and proline metabolism
beta-Alanine metabolism
Glutathione metabolism
Metabolic pathways
Orthology
K00802  
spermine synthase
Genes
HSA: 
6611(SMS)
PTR: 
472307(SMS) 739762(SMS)
PPS: 
GGO: 
PON: 
MCC: 
698179(SMS)
MCF: 
MMU: 
20603(Sms) 671878(Gm14680)
RNO: 
363469(Sms)
CGE: 
HGL: 
TUP: 
CFA: 
480861(SMS)
AML: 
FCA: 
PTG: 
BTA: 
615950(SMS)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
418602(SMS)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XTR: 
DRE: 
80872(sms)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
410080(GB17327)
NVI: 
TCA: 
BMOR: 
PHU: 
ISC: 
NVE: 
TAD: 
SCE: 
YLR146C(SPE4)
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0C03110(NCAS0C03110)
NDI: 
NDAI_0G02420(NDAI0G02420)
TPF: 
TPHA_0A01420(TPHA0A01420)
TBL: 
TBLA_0A04140(TBLA0A04140)
TDL: 
TDEL_0F04780(TDEL0F04780)
KAF: 
KAFR_0H02120(KAFR0H02120)
MBR: 
AEH: 
HHA: 
 » show all
Taxonomy
Reference
1  [PMID:7396856]
  Authors
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE.
  Title
Studies of inhibition of rat spermidine synthase and spermine synthase.
  Journal
Biochem. J. 187 (1980) 419-28.
  Organism
Rattus norvegicus
Reference
2  [PMID:520313]
  Authors
Pajula RL, Raina A, Eloranta T.
  Title
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain.
  Journal
Eur. J. Biochem. 101 (1979) 619-26.
  Organism
Bos taurus
Reference
3  [PMID:6798961]
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem. J. 197 (1981) 315-20.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
74812-43-4

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