KEGG   ENZYME: 2.5.1.22Help
Entry
EC 2.5.1.22                 Enzyme                                 

Name
spermine synthase;
spermidine aminopropyltransferase;
spermine synthetase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase
Reaction(IUBMB)
S-adenosylmethioninamine + spermidine = S-methyl-5'-thioadenosine + spermine [RN:R02869]
Reaction(KEGG)
Substrate
S-adenosylmethioninamine [CPD:C01137];
spermidine [CPD:C00315]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
spermine [CPD:C00750]
Comment
This enzyme is not identical with EC 2.5.1.16 (spermidine synthase) or EC 2.5.1.23 (sym-norspermidine synthase).
Pathway
Cysteine and methionine metabolism
Arginine and proline metabolism
beta-Alanine metabolism
Glutathione metabolism
Metabolic pathways
Orthology
K00802  
spermine synthase
Genes
HSA: 
6611(SMS)
PTR: 
472307(SMS) 739762(SMS)
PPS: 
GGO: 
PON: 
MCC: 
698179(SMS)
MMU: 
20603(Sms) 671878(Gm14680)
RNO: 
363469(Sms)
CFA: 
480861(SMS)
AML: 
FCA: 
BTA: 
615950(SMS)
SSC: 
ECB: 
MDO: 
SHR: 
OAA: 
GGA: 
418602(SMS)
MGP: 
TGU: 
ACS: 
XTR: 
DRE: 
80872(sms)
TRU: 
OLA: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
NVI: 
100116075(NV11021)
TCA: 
PHU: 
ISC: 
NVE: 
TAD: 
SCE: 
YLR146C(SPE4)
KLA: 
CGR: 
MBR: 
AEH: 
HHA: 
 » show all
Taxonomy
Reference
1  [PMID:7396856]
  Authors
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE.
  Title
Studies of inhibition of rat spermidine synthase and spermine synthase.
  Journal
Biochem. J. 187 (1980) 419-28.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:520313]
  Authors
Pajula RL, Raina A, Eloranta T.
  Title
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain.
  Journal
Eur. J. Biochem. 101 (1979) 619-26.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
74812-43-4

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