KEGG   ENZYME: 2.5.1.22Help
Entry
EC 2.5.1.22                 Enzyme                                 

Name spermine synthase;
spermidine aminopropyltransferase;
spermine synthetase
Class Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only
sub-subclass identified to date)
BRITE hierarchy
Sysname S-adenosylmethioninamine:spermidine 3-aminopropyltransferase
Reaction(IUBMB) S-adenosylmethioninamine + spermidine = S-methyl-5'-thioadenosine +
spermine [RN:R02869]
Reaction(KEGG) R02869
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Substrate S-adenosylmethioninamine [CPD:C01137];
spermidine [CPD:C00315]
Product S-methyl-5'-thioadenosine [CPD:C00170];
spermine [CPD:C00750]
Comment This enzyme is not identical with EC 2.5.1.16 (spermidine synthase)
or EC 2.5.1.23 (sym-norspermidine synthase).
Pathway PATH: ec00270  Cysteine and methionine metabolism
PATH: ec00330  Arginine and proline metabolism
PATH: ec00410  beta-Alanine metabolism
PATH: ec00480  Glutathione metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00802  spermine synthase
Genes HSA: 6611(SMS)
PTR: 472307(SMS)
MCC: 698179(SMS)
MMU: 20603(Sms)
RNO: 683008
CFA: 480861(SMS)
BTA: 615950(SMS)
SSC: 100153052
ECB: 100051857
MDO: 100012760
OAA: 100083114
GGA: 418602(SMS)
TGU: 100228014
DRE: 80872(sms)
BFO: BRAFLDRAFT_124222
CIN: 100184953
SPU: 584264
DME: Dmel_CG4300
DPO: Dpse_GA18092
AGA: AgaP_AGAP005325
AAG: AaeL_AAEL001378
TCA: 656524
NVE: NEMVE_v1g234527
SCE: YLR146C(SPE4)
KLA: KLLA0D17094g
DHA: DEHA0E17149g
CGR: CAGL0M04609g
AEH: Mlg_0336
HHA: Hhal_0951
Taxonomy
Structures PDB: 1UIR  3C6K  3C6M  
Reference
  Authors
  Title

  Journal
  Organism
1  [PMID:7396856]
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE.
Studies of inhibition of rat spermidine synthase and spermine
synthase.
Biochem. J. 187 (1980) 419-28.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
2  [PMID:520313]
Pajula RL, Raina A, Eloranta T.
Polyamine synthesis in mammalian tissues. Isolation and
characterization of spermine synthase from bovine brain.
Eur. J. Biochem. 101 (1979) 619-26.
Bos taurus [GN:bta]
Other DBs ExplorEnz - The Enzyme Database: 2.5.1.22
IUBMB Enzyme Nomenclature: 2.5.1.22
ExPASy - ENZYME nomenclature database: 2.5.1.22
BRENDA, the Enzyme Database: 2.5.1.22
CAS: 74812-43-4

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