| Entry |
|
|---|
| Name |
spermine synthase;
spermidine aminopropyltransferase;
spermine synthetase |
|---|
| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only
sub-subclass identified to date)
 |
|---|
| Sysname |
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase |
|---|
| Reaction(IUBMB) |
S-adenosylmethioninamine + spermidine = S-methyl-5'-thioadenosine +
spermine [RN:R02869] |
|---|
| Reaction(KEGG) |
R02869
 |
|---|
| Substrate |
S-adenosylmethioninamine [CPD:C01137];
spermidine [CPD:C00315] |
|---|
| Product |
S-methyl-5'-thioadenosine [CPD:C00170];
spermine [CPD:C00750] |
|---|
| Comment |
This enzyme is not identical with EC 2.5.1.16 (spermidine synthase)
or EC 2.5.1.23 (sym-norspermidine synthase). |
|---|
| Pathway |
PATH: ec00270 Cysteine and methionine metabolism
PATH: ec00330 Arginine and proline metabolism
PATH: ec00410 beta-Alanine metabolism
PATH: ec00480 Glutathione metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00802 spermine synthase |
|---|
| Genes |
HSA: 6611(SMS)
PTR: 472307(SMS)
MCC: 698179(SMS)
MMU: 20603(Sms)
RNO: 683008
CFA: 480861(SMS)
BTA: 615950(SMS)
SSC: 100153052
ECB: 100051857
MDO: 100012760
OAA: 100083114
GGA: 418602(SMS)
TGU: 100228014
DRE: 80872(sms)
BFO: BRAFLDRAFT_124222
CIN: 100184953
SPU: 584264
DME: Dmel_CG4300
DPO: Dpse_GA18092
AGA: AgaP_AGAP005325
AAG: AaeL_AAEL001378
TCA: 656524
NVE: NEMVE_v1g234527
SCE: YLR146C(SPE4)
KLA: KLLA0D17094g
DHA: DEHA0E17149g
CGR: CAGL0M04609g
AEH: Mlg_0336
HHA: Hhal_0951
 |
|---|
| Structures |
PDB: 1UIR 3C6K 3C6M |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:7396856]
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE.
Studies of inhibition of rat spermidine synthase and spermine
synthase.
Biochem. J. 187 (1980) 419-28.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:520313]
Pajula RL, Raina A, Eloranta T.
Polyamine synthesis in mammalian tissues. Isolation and
characterization of spermine synthase from bovine brain.
Eur. J. Biochem. 101 (1979) 619-26.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.5.1.22
IUBMB Enzyme Nomenclature: 2.5.1.22
ExPASy - ENZYME nomenclature database: 2.5.1.22
BRENDA, the Enzyme Database: 2.5.1.22
CAS: 74812-43-4 |
|---|
