| Entry |
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| Name |
spermine synthase;
spermidine aminopropyltransferase;
spermine synthetase
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase
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| Reaction(IUBMB) |
S-adenosylmethioninamine + spermidine = S-methyl-5'-thioadenosine + spermine [RN: R02869]
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| Reaction(KEGG) |
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| Substrate |
S-adenosylmethioninamine [CPD: C01137];
spermidine [CPD: C00315]
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| Product |
S-methyl-5'-thioadenosine [CPD: C00170];
spermine [CPD: C00750]
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| Comment |
This enzyme is not identical with EC 2.5.1.16 (spermidine synthase) or EC 2.5.1.23 (sym-norspermidine synthase).
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| Pathway |
| Cysteine and methionine metabolism | | Arginine and proline metabolism | | beta-Alanine metabolism | | Glutathione metabolism | | Metabolic pathways |
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | PHU: | | ISC: | | NVE: | | TAD: | | SCE: | | KLA: | | CGR: | | MBR: | | AEH: | | HHA: | |
» show all
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| Reference |
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| Authors |
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE. |
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| Title |
Studies of inhibition of rat spermidine synthase and spermine synthase. |
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| Journal |
Biochem. J. 187 (1980) 419-28. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Pajula RL, Raina A, Eloranta T. |
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| Title |
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain. |
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| Journal |
Eur. J. Biochem. 101 (1979) 619-26. |
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| Organism |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 74812-43-4 |
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