| Entry |
|
|---|
| Name |
farnesyltranstransferase;
geranylgeranyl-diphosphate synthase;
geranylgeranyl pyrophosphate synthetase;
geranylgeranyl-PP synthetase;
farnesyltransferase;
geranylgeranyl pyrophosphate synthase |
|---|
| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only
sub-subclass identified to date)
 |
|---|
| Sysname |
trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate
farnesyltranstransferase |
|---|
| Reaction(IUBMB) |
trans,trans-farnesyl diphosphate + isopentenyl diphosphate =
diphosphate + geranylgeranyl diphosphate [RN:R02061] |
|---|
| Reaction(KEGG) |
R02061
 |
|---|
| Substrate |
trans,trans-farnesyl diphosphate [CPD:C00448];
isopentenyl diphosphate [CPD:C00129] |
|---|
| Product |
diphosphate [CPD:C00013];
geranylgeranyl diphosphate [CPD:C00353] |
|---|
| Comment |
Some forms of this enzyme will also use geranyl diphosphate and
dimethylallyl diphosphate as donors; it will not use larger prenyl
diphosphates as efficient donors. |
|---|
| Pathway |
PATH: ec00900 Terpenoid backbone biosynthesis
PATH: ec01062 Biosynthesis of terpenoids and steroids
PATH: ec01066 Biosynthesis of alkaloids derived from terpenoid and
polyketide
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00804 geranylgeranyl pyrophosphate synthetase |
|---|
| Genes |
HSA: 9453(GGPS1)
MMU: 14593(Ggps1)
RNO: 291211(Ggps1)
CFA: 479198(GGPS1)
BTA: 780882(GGPS1)
SSC: 100155232
ECB: 100050954
MDO: 100021237
OAA: 100081573
GGA: 427092(GGPS1)
TGU: 100232753
DRE: 336798(ggps1)
DME: Dmel_CG8593(qm)
DPO: Dpse_GA21189
AME: 727189
NVE: NEMVE_v1g235912
ATH: AT2G23800(GGPS2) AT4G36810(GGPS1)
CME: CMK058C
SCE: YPL069C(BTS1)
AGO: AGOS_AEL238C
KLA: KLLA0E23375g
PIC: PICST_32799(BET4) PICST_46658(BTS1) PICST_55783(RAM2)
CAL: CaO19.6674(BTS1)
CGR: CAGL0H05269g
YLI: YALI0D17050g
CNE: CNI00090
UMA: UM04459.1
DDI: DDB_0233098
TVA: TVAG_257590
MAQ: Maqu_0854
NOC: Noc_2231
HHA: Hhal_1613
PNU: Pnuc_0193
RFR: Rfer_1267
NET: Neut_0825
NMU: Nmul_A1814
DPS: DP2699
ADE: Adeh_0378
SAT: SYN_02457 SYN_03252
RET: RHE_PD00244(ctrE)
BRA: BRADO1615(crtE) BRADO6509(crtE)
BBT: BBta_6440(crtE)
RPA: RPA1519(crtE)
RPB: RPB_4004
RPC: RPC_1290
RPD: RPD_3759
RPE: RPE_1324
MEX: Mext_2727
MDI: METDI3493(crtE)
MCH: Mchl_2954
RSH: Rsph17029_1909
RSQ: Rsph17025_2039
RDE: RD1_0114(crtE)
RRU: Rru_A2983
LSL: LSL_1028
LDB: Ldb1422(crtE)
CTC: CTC01577
STH: STH1844
TTE: TTE1296(ispA)
MTU: Rv3398c(idsA1)
MTC: MT3506
MRA: MRA_3438(idsA1)
MBO: Mb3431c(idsA1)
MBB: BCG_3468c(idsA1)
SCO: SCO6763(SC6A5.12)
SMA: SAV_2997(ptlB)
FRA: Francci3_0822
FAL: FRAAL1431(fppS)
ACE: Acel_1696
SEN: SACE_3979 SACE_4328 SACE_4646(ptlB) SACE_4909 SACE_5289
CTA: CTA_0681(ispA)
PCU: pc1696(crtE)
ABA: Acid345_3432
SYN: slr0739(crtE)
SYW: SYNW0742(crtE)
SYC: syc0760_d(crtE)
SYF: Synpcc7942_0776
SYD: Syncc9605_1926
SYE: Syncc9902_0739
SYG: sync_0991(crtE)
SYR: SynRCC307_0751(crtE)
SYX: SynWH7803_1569(crtE)
SYP: SYNPCC7002_A1085(crtE)
CYA: CYA_0377(crtE)
CYB: CYB_1859(crtE)
TEL: tll0020(crtE)
MAR: MAE_14550(crtE)
CYT: cce_0877(crtE)
GVI: gvip043(crtE)
ANA: alr0213
PMA: Pro1042(crtE) Pro1129(ispA)
PMM: PMM1070(crtE)
PMT: PMT1109(crtE)
PMN: PMN2A_0681
PMB: A9601_06741(sds) A9601_11751(ispA)
PMC: P9515_06831(sds) P9515_11601(ispA)
PMF: P9303_09331(ispA)
PMG: P9301_06441(sds) P9301_11761(ispA)
PME: NATL1_06761(sds) NATL1_15151(ispA)
TER: Tery_4173
DTH: DICTH_1170
MBU: Mbur_2399
MTP: Mthe_0472
MHU: Mhun_2886
HWA: HQ2889A(idsA)
NPH: NP3696A(idsA_3)
PTO: PTO1199
RCI: RCIX2437(crtE)
SSO: SSO0061(gdS-1)
STO: ST2058
SAI: Saci_0092(gds)
 |
|---|
| Structures |
PDB: 2DH4 2Q80 2Z4V 2Z4W 2Z4X 2Z4Y 2Z4Z 2Z50 2Z52 2Z78
2Z7H 2Z7I |
|---|
Reference
Authors
Title
Journal
|
1
Sagami, H., Ishi, K. and Ogura, K.
Occurrence and unusual properties of geranylgeranyl pyrophosphate
synthetase of pig liver.
Biochem. Int. 3 (1981) 669-675. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.5.1.29
IUBMB Enzyme Nomenclature: 2.5.1.29
ExPASy - ENZYME nomenclature database: 2.5.1.29
BRENDA, the Enzyme Database: 2.5.1.29
CAS: 9032-58-0 |
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