| Entry |
|
|---|
| Name |
cystathionine gamma-synthase;
O-succinyl-L-homoserine succinate-lyase (adding cysteine);
O-succinylhomoserine (thiol)-lyase;
homoserine O-transsuccinylase;
O-succinylhomoserine synthase;
O-succinylhomoserine synthetase;
cystathionine synthase;
cystathionine synthetase;
homoserine transsuccinylase;
4-O-succinyl-L-homoserine:L-cysteine
S-(3-amino-3-carboxypropyl)transferase |
|---|
| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only
sub-subclass identified to date)
 |
|---|
| Sysname |
O4-succinyl-L-homoserine:L-cysteine
S-(3-amino-3-carboxypropyl)transferase |
|---|
| Reaction(IUBMB) |
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate
[RN:R03260] |
|---|
| Reaction(KEGG) |
R03260;
(other) R00999 R01288 R02508 R03132 R03217 R04944 R04945 R04946
 |
|---|
| Substrate |
O4-succinyl-L-homoserine;
L-cysteine [CPD:C00097] |
|---|
| Product |
L-cystathionine [CPD:C02291];
succinate [CPD:C00042] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and
methanethiol as replacing agents, producing homocysteine and
methionine, respectively. In the absence of thiol, can also catalyse
beta,gamma-elimination to form 2-oxobutanoate, succinate and
ammonia. |
|---|
| Pathway |
PATH: ec00270 Cysteine and methionine metabolism
PATH: ec00450 Selenoamino acid metabolism
PATH: ec00920 Sulfur metabolism
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01739 cystathionine gamma-synthase |
|---|
| Genes |
ATH: AT3G01120(MTO1)
POP: POPTR_835709
VVI: 100267880
OSA: 4332956(Os03g0376100)
PPP: PHYPADRAFT_124339
CRE: CHLREDRAFT_24268(CGS1)
OLU: OSTLU_17120(CGS2) OSTLU_33390(CGS1)
CME: CMF156C
SCE: YJR130C(STR2) YML082W
AGO: AGOS_AER164C
KLA: KLLA0B04378g KLLA0E21406g
DHA: DEHA0D10285g
PIC: PICST_36608 PICST_59680
CAL: CaO19.1033(STR2) CaO19.7297
CGR: CAGL0I01276g CAGL0M00550g
YLI: YALI0C22088g YALI0D17402g
SPO: SPAC23A1.14c SPBC15D4.09c
NCR: NCU02430
MGR: MGG_03583
ANI: AN3456.2
AFM: AFUA_3G05480
AOR: AO090003001113 AO090020000019
ANG: An01g10010 An11g11160
CNE: CNC01220
UMA: UM04053.1
EHI: EHI_142250 EHI_144610
LMA: LmjF35.3230
ECO: b3939(metB)
ECJ: JW3910(metB)
ECD: ECDH10B_4128(metB)
EBW: BWG_3608(metB)
ECE: Z5494(metB)
ECS: ECs4868
ECF: ECH74115_5399(metB)
ETW: ECSP_5009(metB)
ECG: E2348C_4243(metB)
ECC: c4892(metB)
ECI: UTI89_C4524(metB)
ECP: ECP_4148
ECV: APECO1_2532(metB)
ECW: EcE24377A_4479(metB)
ECX: EcHS_A4172(metB)
ECM: EcSMS35_4381(metB)
ECY: ECSE_4233
ECL: EcolC_4076
ECK: EC55989_4421(metB)
ECQ: ECED1_4642(metB)
ECR: ECIAI1_4148(metB)
ECT: ECIAI39_3055(metB)
ECZ: ECS88_4390(metB)
EUM: ECUMN_4469(metB)
ELF: LF82_1318(metB)
EBL: B21_03774(metB)
EBD: ECBD_4084
EBR: ECB_03825(metB)
EFE: EFER_3832(metB)
STY: STY3769(metB)
STT: t3518(metB)
SPT: SPA3943(metB)
SEK: SSPA3670
SPQ: SPAB_05081
SEI: SPC_4209(metB)
SEC: SC3991(metB)
SEH: SeHA_C4434(metB)
SEE: SNSL254_A4431(metB)
SEW: SeSA_A4317(metB)
SEA: SeAg_B4347(metB)
SED: SeD_A4501(metB)
SEG: SG3320(metB)
SET: SEN3890(metB)
SES: SARI_03556
STM: STM4100(metB)
YPE: YPO0115(metB)
YPM: YP_0117(metC1)
YPA: YPA_0263
YPN: YPN_3740
YPG: YpAngola_A3807(metB)
YPP: YPDSF_3792
YPS: YPTB0105(metB)
YPI: YpsIP31758_0121(metB)
YPY: YPK_4095
YPB: YPTS_0108
YEN: YE0111(metB) YE1469(metB)
SFL: SF4017(metB)
SFX: S3730(metB)
SFV: SFV_4009(metB)
SSN: SSON_4113(metB)
SBO: SBO_3959(metB)
SBC: SbBS512_E4425(metB)
SDY: SDY_3774(metB)
ECA: ECA4252(metB)
PCT: PC1_0177
ETA: ETA_01270(metB)
PLU: plu4756(metB)
PAY: PAU_04244(metB)
SGL: SG2163
ENT: Ent638_4035
ESA: ESA_03822
KPN: KPN_04233(metB)
KPE: KPK_5446(metB)
KPU: KP1_0095(metB)
CKO: CKO_03055
SPE: Spro_4786
PMR: PMI3223(metB)
EIC: NT01EI_3805
BFL: Bfl598(metB)
BPN: BPEN_620(metB)
DDA: Dd703_3791
DZE: Dd1591_0120
HIN: HI0086(metB)
HIT: NTHI0100(metB)
HIP: CGSHiEE_02855
HAP: HAPS_2273(metB)
HSO: HS_1345(metB)
HSM: HSM_0277
PMU: PM0995(metB)
MSU: MS1627(metC)
APL: APL_0683(metB)
APJ: APJL_0679(metB)
APA: APP7_0723
ASU: Asuc_1846
AAP: NT05HA_1400
AAT: D11S_1900
XFA: XF0864
XFT: PD1812(metB)
XFM: Xfasm12_1985
XFN: XfasM23_1914
XCC: XCC2856(metB)
XCB: XC_1252
XCA: xccb100_1298
XCV: XCV3176(metB)
XAC: XAC3039(metB)
XOO: XOO1818(metB)
XOM: XOO_1717
XOP: PXO_01681(metB)
SML: Smlt3634(metB)
SMT: Smal_3050
VCH: VC2683
VCO: VC0395_A2256(metB)
VCM: VCM66_2603(metB)
VCJ: VCD_001685
VVU: VV1_1364
VVY: VV3008
VPA: VP2765
VHA: VIBHAR_00049
VSP: VS_2894
VFI: VF_2267(metB)
VFM: VFMJ11_2379(metB)
VSA: VSAL_I2747(metB)
PPR: PBPRA0261
PPU: PP_0659(metB)
PPF: Pput_0693
PFL: PFL_3814(mdeA)
PEN: PSEEN4039
SON: SO_4056(metB)
SDN: Sden_0615
SFR: Sfri_3551
SAZ: Sama_3171
SBL: Sbal_3776
SBM: Shew185_0536
SBN: Sbal195_0560
SBP: Sbal223_0564
SLO: Shew_0520
SPC: Sputcn32_0616
SSE: Ssed_4041
SPL: Spea_0560
SHE: Shewmr4_3439
SHM: Shewmr7_0512
SHN: Shewana3_3614
SHW: Sputw3181_3554
SHL: Shal_0622
SWD: Swoo_0622
SWP: swp_4557
ILO: IL0599
CPS: CPS_0455(metB)
PHA: PSHAa2723(metB)
PAT: Patl_4021
MAQ: Maqu_1897
PIN: Ping_0757
NOC: Noc_0842
AEH: Mlg_1615
MMW: Mmwyl1_3697
AHA: AHA_0589(metB)
ASA: ASA_3795(metB)
TAU: Tola_0128
BCI: BCI_0163(metB)
NMA: NMA1012
NME: NMB0802(metB)
CVI: CV_3394 CV_4049(metB)
RSO: RSp0781(metB)
BPM: BURPS1710b_A2511
BTE: BTH_II1484
BAM: Bamb_4283 Bamb_6437
VEI: Veis_0265
HPY: HP0106
HPJ: jhp0098(metB)
HPA: HPAG1_0106
HHE: HH0062(metB)
HAC: Hac_1464(metB)
GUR: Gura_3857 Gura_3858
PPD: Ppro_1830 Ppro_1831
DOL: Dole_1401
ADE: Adeh_3143
SCL: sce6169(metB1)
HOH: Hoch_3411
SFU: Sfum_2670
SME: SMc02595(metB)
RET: RHE_PE00244(mdeAe)
NWI: Nwi_0592
NHA: Nham_0684
MEX: Mext_2858
MDI: METDI3626
MRD: Mrad2831_4408 Mrad2831_5099
MET: M446_1414 M446_3453
MPO: Mpop_2976
MCH: Mchl_3084
MNO: Mnod_1031 Mnod_3067
MSL: Msil_0328
SIT: TM1040_1264
RSP: RSP_2917
RSQ: Rsph17025_0780 Rsph17025_4330
JAN: Jann_2286
PDE: Pden_5069
DSH: Dshi_1002(metB1)
MMR: Mmar10_1549 Mmar10_1859 Mmar10_2620
NAR: Saro_2665
SAL: Sala_1086
SWI: Swit_3154
ACR: Acry_2070
RRU: Rru_A0098 Rru_A0786
BSU: BSU11870(yjcI)
BHA: BH0542 BH1627(metB) BH1736
BAN: BA4480(metC-1)
BAR: GBAA4480(metC-1)
BAA: BA_4927
BAT: BAS4158
BAH: BAMEG_4516(metI)
BAI: BAA_4499(metI)
BCE: BC4253
BCA: BCE_4336(metC)
BCZ: BCZK4007(metC)
BCR: BCAH187_A4389(metI)
BCB: BCB4264_A4370(metI)
BCU: BCAH820_4276(metI)
BCG: BCG9842_B0864(metI)
BCQ: BCQ_4041(metC)
BCX: BCA_4367(metI)
BCY: Bcer98_2985
BTK: BT9727_3997(metC)
BTL: BALH_3852(metC)
BWE: BcerKBAB4_4110
BLI: BL02660(yjcI)
BLD: BLi01289(yjcI)
BCL: ABC0021 ABC1867(metI) ABC1945
BAY: RBAM_011930(yjcI)
BPU: BPUM_1119(yjcI)
OIH: OB2949
GKA: GK0866
GTN: GTNG_0745 GTNG_2270
GWC: GWCH70_0801
AFL: Aflv_2067
SAU: SA0347 SA0419(metB)
SAV: SAV0359 SAV0460(yrhB)
SAM: MW0335 MW0415(metB)
SAR: SAR0356 SAR0460
SAS: SAS0335 SAS0418
SAC: SACOL0431 SACOL0503
SAB: SAB0309c SAB0410
SAJ: SaurJH9_0407 SaurJH9_0482
SAH: SaurJH1_0417 SaurJH1_0495
SAE: NWMN_0351
SEP: SE2323 SE2379
SER: SERP0037 SERP0095
SHA: SH2548(metB) SH2635
SSP: SSP0253 SSP2413
LMO: lmo1680
LMF: LMOf2365_1704
LMH: LMHCC_0886
LMC: Lm4b_01693
LIN: lin1788
LWE: lwe1698
LSP: Bsph_3397
BBE: BBR47_38780(metI)
LLA: L0102(metB1)
LLM: llmg_2181(metB1)
SPN: SP_1525
SPD: SPD_1353
SPR: spr1377(metB)
SPW: SPCG_1510(metB)
SPX: SPG_1450(metB)
SPV: SPH_1637
SNM: SP70585_1564
SJJ: SPJ_1429
SPP: SPP_1545
SNT: SPT_1463
SMU: SMU.1675(metB)
STC: str0352(metB1)
STL: stu0352(metB1)
STE: STER_0390
SSA: SSA_1737(metB)
SSU: SSU05_1562
SSV: SSU98_1571
SGO: SGO_1636
LPL: lp_2634(metB)
LME: LEUM_1237 LEUM_1805
CAC: CAC0390 CAC0930(metB)
CPE: CPE0176(metB)
CTH: Cthe_2799
CKL: CKL_1002(metB1) CKL_1632(metB2)
AMT: Amet_3706 Amet_3707
STH: STH2363
DSY: DSY3983
TTE: TTE1574(metC2)
MTU: Rv1079(metB)
MTC: MT1110(metB)
MRA: MRA_1089(metB)
MTF: TBFG_11097
MBO: Mb1108(metB)
MBB: BCG_1137(metB)
MBT: JTY_1110(metB)
MLE: ML2394(metB)
MLB: MLBr_02394(metB)
MPA: MAP1026(metB)
MAV: MAV_1203
MSM: MSMEG_5265
MUL: MUL_0201(metB)
MVA: Mvan_4670
MGI: Mflv_2046
MAB: MAB_1197
MMC: Mmcs_4146
MJL: Mjls_4377
MMI: MMAR_4388(metB)
CGL: NCgl2360(cgl2446)
CGB: cg2687(metB)
CGT: cgR_2348
CEF: CE2343(metB)
CJK: jk0055(metB)
CAR: cauri_2045(metB)
CKP: ckrop_0829
NFA: nfa48270(metB)
RHA: RHA1_ro05845(metB)
RER: RER_42650(metB)
ROP: ROP_59060(metB)
SCO: SCO4958(2SCK31.18)
SMA: SAV_3305(metB)
SGR: SGR_2579
LXX: Lxx03230(metB)
CMI: CMM_0873(metB)
CMS: CMS_0128
ART: Arth_0718 Arth_2849
AAU: AAur_0889(metB) AAur_3037(metB)
ACH: Achl_2761
RSA: RSal33209_0400 RSal33209_0897
KRH: KRH_20930(metB)
BCV: Bcav_1055
XCE: Xcel_2638
NCA: Noca_0976 Noca_3943
TFU: Tfu_0440 Tfu_0632
TCU: Tcur_1050
FRA: Francci3_0374
FRE: Franean1_6425
FAL: FRAAL0783(metB)
NML: Namu_4420
KRA: Krad_1092
SEN: SACE_0902(metB)
SVI: Svir_31860
AMI: Amir_0702
STP: Strop_0920
SAQ: Sare_0863
CAI: Caci_0658
BLO: BL1155(metB)
BLJ: BLD_0913(metC3)
BAD: BAD_0491(metB)
BLA: BLA_1095(metB)
BLC: Balac_0563
BLT: Balat_0563
RXY: Rxyl_2537
LIL: LA0113(metC)
LIC: LIC10101(met-7)
LBJ: LBJ_0092
LBL: LBL_0043
ABA: Acid345_1913 Acid345_1981 Acid345_2499
SUS: Acid_3250 Acid_4794 Acid_5643
SRU: SRU_1161
FNU: FN1745
GAU: GAU_3167(metB)
RBA: RB6442(metB)
SYW: SYNW0674 SYNW0675(metB)
SYD: Syncc9605_1994 Syncc9605_1995
SYE: Syncc9902_0665 Syncc9902_0666
SYG: sync_0622 sync_0623(metB)
SYX: SynWH7803_0586(metB) SynWH7803_0587
CYN: Cyan7425_1266
PMA: Pro0404(metC) Pro0405(metC)
PMM: PMM0408 PMM0409(metB)
PMT: PMT0225 PMT0226(metB)
PMN: PMN2A_1742 PMN2A_1743
PMI: PMT9312_0403 PMT9312_0404
PMB: A9601_04581 A9601_04591(metB)
PMC: P9515_04691 P9515_04701(metB)
PMF: P9303_21181(metB) P9303_21191
PMG: P9301_04271 P9301_04281(metB)
PMH: P9215_04841 P9215_04851(metB)
PME: NATL1_04591 NATL1_04601(metB)
CPC: Cpar_0673
CCH: Cag_1264
CPH: Cpha266_0732
CLI: Clim_0667
PVI: Cvib_1358
PLT: Plut_1548 Plut_1563
PPH: Ppha_2001
RRS: RoseRS_1055 RoseRS_4472
RCA: Rcas_3473
CAU: Caur_1458
CAG: Cagg_1948
CHL: Chy400_1581
HAU: Haur_0506 Haur_4016
STI: Sthe_2023
DGE: Dgeo_1004
TMA: TM1270
HAL: VNG1172G(metB)
HMA: rrnAC2414(metB)
NPH: NP4746A(metB)
HUT: Huta_0933
TAC: Ta0531
TVO: TVN1007
PTO: PTO1102
PHO: PH1093
PAB: PAB0605(metB)
PFU: PF1266
TKO: TK1449
APE: APE_2068(metB)
IHO: Igni_1102
HBU: Hbut_0818
SSO: SSO2368(metB)
STO: ST0506
SAI: Saci_0971
SIS: LS215_0196
SIA: M1425_0165
SIM: M1627_0165
SID: M164_0184
SIY: YG5714_0169
SIN: YN1551_2771
MSE: Msed_0673
PAI: PAE2420
PIS: Pisl_0881
PCL: Pcal_0316
PAS: Pars_1485
CMA: Cmaq_1364
TNE: Tneu_0243
KCR: Kcr_0985
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5340123]
Flavin M, Slaughter C.
Enzymatic synthesis of homocysteine or methionine directly from
O-succinyl-homoserine.
Biochim. Biophys. Acta. 132 (1967) 400-5.
Salmonella typhimurium |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5922970]
Kaplan MM, Flavin M.
Cystathionine gamma-synthetase of Salmonella. Catalytic properties
of a new enzyme in bacterial methionine biosynthesis.
J. Biol. Chem. 241 (1966) 4463-71.
Salmonella typhimurium, Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6016326]
Wiebers JL, Garner HR.
Homocysteine and cysteine synthetases of Neurospora crassa.
Purification, properties, and feedback control of activity.
J. Biol. Chem. 242 (1967) 12-23.
Neurospora crassa [GN:ncr] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:12325384]
Wiebers JL, Garner HR.
Acyl derivatives of homoserine as substrates for homocysteine
synthesis in Neurospora crassa, yeast, and Escherichia coli.
J. Biol. Chem. 242 (1967) 5644-9.
Escherichia coli [GN:eco], Neurospora crassa [GN:ncr] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:9843488]
Clausen T, Huber R, Prade L, Wahl MC, Messerschmidt A.
Crystal structure of Escherichia coli cystathionine gamma-synthase
at 1.5 A resolution.
EMBO. J. 17 (1998) 6827-38.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:9531508]
Ravanel S, Gakiere B, Job D, Douce R.
Cystathionine gamma-synthase from Arabidopsis thaliana: purification
and biochemical characterization of the recombinant enzyme
overexpressed in Escherichia coli.
Biochem. J. 331 ( Pt 2) (1998) 639-48.
Escherichia coli [GN:eco], Arabidopsis thaliana [GN:ath] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.5.1.48
IUBMB Enzyme Nomenclature: 2.5.1.48
ExPASy - ENZYME nomenclature database: 2.5.1.48
BRENDA, the Enzyme Database: 2.5.1.48
CAS: 9030-70-0 |
|---|
