| Entry |
|
|---|
| Name |
N-acylneuraminate-9-phosphate synthase;
N-acetylneuraminate 9-phosphate lyase;
N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase;
N-acetylneuraminate 9-phosphate synthetase;
N-acylneuraminate-9-phosphate pyruvate-lyase
(pyruvate-phosphorylating);
sialic acid 9-phosphate synthetase |
|---|
| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only
sub-subclass identified to date)
 |
|---|
| Sysname |
phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate
1-(2-carboxy-2-oxoethyl)transferase |
|---|
| Reaction(IUBMB) |
phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O =
N-acylneuraminate 9-phosphate + phosphate [RN:R02769] |
|---|
| Reaction(KEGG) |
R02769 > R04435
 |
|---|
| Substrate |
phosphoenolpyruvate [CPD:C00074];
N-acyl-D-mannosamine 6-phosphate [CPD:C00686];
H2O [CPD:C00001] |
|---|
| Product |
N-acylneuraminate 9-phosphate [CPD:C01200];
phosphate [CPD:C00009] |
|---|
| Comment |
Acts on N-glycoloyl and N-acetyl-derivatives. |
|---|
| Pathway |
PATH: ec00520 Amino sugar and nucleotide sugar metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K05304 sialic acid synthase |
|---|
| Genes |
HSA: 54187(NANS)
PTR: 743934(NANS)
MCC: 715459
MMU: 94181(Nans)
RNO: 298071(Nans)
CFA: 481624(NANS)
BTA: 540602(NANS)
SSC: 100155883(NANS)
ECB: 100064126(NANS)
MDO: 100014569
OAA: 100074951
GGA: 427283(NANS)
TGU: 100227675
XLA: 432051 447417
DRE: 322780
BFO: BRAFLDRAFT_115797
SPU: 577884
DME: Dmel_CG5232(Sas)
DPO: Dpse_GA18754
DAN: Dana_GF17956
AGA: AgaP_AGAP004460
AAG: AaeL_AAEL000097
CQU: CpipJ_CPIJ013964
 |
|---|
| Structures |
PDB: 1WVO |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13743311]
ROSEMAN S, JOURDIAN GW, WATSON D, ROOD R.
Enzymatic synthesis of sialic acid 9-phosphates.
Proc. Natl. Acad. Sci. U. S. A. 47 (1961) 958-61.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5928202]
Watson DR, Jourdian GW, Roseman S.
The sialic acids. 8. Sialic acid 9-phosphate synthetase.
J. Biol. Chem. 241 (1966) 5627-36.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10873658]
Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K.
Molecular cloning and expression of the mouse N-acetylneuraminic
acid 9-phosphate synthase which does not have deaminoneuraminic acid
(KDN) 9-phosphate synthase activity.
Biochem. Biophys. Res. Commun. 273 (2000) 642-8.
Mus musculus [GN:mmu] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.5.1.57
IUBMB Enzyme Nomenclature: 2.5.1.57
ExPASy - ENZYME nomenclature database: 2.5.1.57
BRENDA, the Enzyme Database: 2.5.1.57
CAS: 9031-58-7 |
|---|
