KEGG   ENZYME: 2.5.1.91Help
Entry
EC 2.5.1.91                 Enzyme                                 

Name
all-trans-decaprenyl-diphosphate synthase;
decaprenyl-diphosphate synthase;
decaprenyl pyrophosphate synthetase;
polyprenylpyrophosphate synthetase;
terpenoidallyltransferase;
terpenyl pyrophosphate synthetase;
trans-prenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate [RN:R09249]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-decaprenyl diphosphate [CPD:C17432]
Comment
This enzyme catalyses the condensation reactions resulting in the formation of all-trans-decaprenyl diphosphate, the isoprenoid side chain of ubiquinone-10 and menaquinone-10. The enzyme adds seven isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.
History
EC 2.5.1.91 created 2010
Pathway
Terpenoid backbone biosynthesis
Orthology
K12504  
decaprenyl-diphosphate synthase subunit 1
K12505  
decaprenyl-diphosphate synthase subunit 2
Genes
HSA: 
23590(PDSS1) 57107(PDSS2)
PTR: 
450362(PDSS1) 462912(PDSS2)
PPS: 
100974595(PDSS2) 100994534(PDSS1)
GGO: 
PON: 
NLE: 
100588079(PDSS1) 100588805(PDSS2)
MCC: 
698357(PDSS2) 707598(PDSS1)
MCF: 
CJC: 
MMU: 
56075(Pdss1) 71365(Pdss2)
RNO: 
100364990(Pdss1) 365592(Pdss2)
CGE: 
100768592(Pdss2) 100772754(Pdss1)
HGL: 
101697310(Pdss1) 101703636(Pdss2)
TUP: 
102476792(PDSS2) 102503271(PDSS1)
CFA: 
481950(PDSS2) 607944(PDSS1)
AML: 
UMR: 
103675843(PDSS2) 103680139(PDSS1)
FCA: 
101087491(PDSS1) 101097150(PDSS2)
PTG: 
102966140(PDSS2) 102971115(PDSS1)
BTA: 
509696(PDSS1) 521115(PDSS2)
BOM: 
102280131(PDSS2) 102280164(PDSS1)
PHD: 
102327277(PDSS1) 102328984(PDSS2)
CHX: 
102177538(PDSS1) 102191138(PDSS2)
OAS: 
101118959(PDSS2) 101121954(PDSS1)
SSC: 
100312977(PDSS2) 100514361(PDSS1)
CFR: 
102507389(PDSS1) 102515007(PDSS2)
BACU: 
103008000(PDSS1) 103020081(PDSS2)
LVE: 
103080757(PDSS1) 103081626(PDSS2)
ECB: 
100065489(PDSS1) 100072062(PDSS2)
MYB: 
102248508(PDSS2) 102254813(PDSS1)
MYD: 
102763370(PDSS2) 102766455(PDSS1)
PALE: 
102887982(PDSS1) 102888555(PDSS2)
MDO: 
100024999(PDSS1) 103099410(PDSS2)
SHR: 
100915254(PDSS2) 100919964(PDSS1)
OAA: 
100075316(PDSS1) 100080833(PDSS2)
GGA: 
420490(PDSS1) 421777(PDSS2)
MGP: 
APLA: 
101797438(PDSS1) 101804694(PDSS2)
TGU: 
100220588(PDSS2) 100226798(PDSS1)
FAB: 
101805919(PDSS2) 101808203(PDSS1)
PHI: 
102102362(PDSS1) 102114098(PDSS2)
FPG: 
101918383(PDSS1) 101919329(PDSS2)
FCH: 
102053247(PDSS1) 102053315(PDSS2)
CLV: 
102086507(PDSS1) 102092561(PDSS2)
ASN: 
102368775(PDSS2) 102383045(PDSS1)
AMJ: 
102558152(PDSS2) 102572921(PDSS1)
PSS: 
102446423(PDSS1) 102453590(PDSS2)
CMY: 
102930852(PDSS2) 102939123(PDSS1)
ACS: 
PBI: 
XTR: 
493532(pdss2) 779676(pdss1)
DRE: 
436624(pdss2) 550349(pdss1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352787(PDSS1) 102358397(PDSS2)
CMK: 
103182197(pdss2) 103183598(pdss1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412735(GB12648) 551463(GB13311)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG12314(Cbr-coq-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
DPP: 
PTM: 
 » show all
Taxonomy
Reference
1  [PMID:16262699]
  Authors
Saiki R, Nagata A, Kainou T, Matsuda H, Kawamukai M.
  Title
Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.
  Journal
FEBS. J. 272 (2005) 5606-22.
  Sequence
[hsa:57107 23590] [mmu:71365 56075]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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