KEGG   ENZYME: 2.5.1.91Help
Entry
EC 2.5.1.91                 Enzyme                                 
Name
all-trans-decaprenyl-diphosphate synthase;
decaprenyl-diphosphate synthase;
decaprenyl pyrophosphate synthetase;
polyprenylpyrophosphate synthetase;
terpenoidallyltransferase;
terpenyl pyrophosphate synthetase;
trans-prenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate [RN:R09249]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-decaprenyl diphosphate [CPD:C17432]
Comment
This enzyme catalyses the condensation reactions resulting in the formation of all-trans-decaprenyl diphosphate, the isoprenoid side chain of ubiquinone-10 and menaquinone-10. The enzyme adds seven isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.
Pathway
Terpenoid backbone biosynthesis
Orthology
K12504  
decaprenyl-diphosphate synthase subunit 1
K12505  
decaprenyl-diphosphate synthase subunit 2
Genes
HSA: 
23590(PDSS1) 57107(PDSS2)
PTR: 
450362(PDSS1) 462912(PDSS2)
PPS: 
100974595(PDSS2) 100994534(PDSS1)
GGO: 
PON: 
MCC: 
698357(PDSS2) 707598(PDSS1)
MMU: 
56075(Pdss1) 71365(Pdss2)
RNO: 
CFA: 
481950(PDSS2) 607944(PDSS1)
AML: 
FCA: 
101087491(PDSS1) 101097150(PDSS2)
BTA: 
509696(PDSS1) 521115(PDSS2)
SSC: 
100312977(PDSS2) 100514361(PDSS1)
ECB: 
100065489(PDSS1) 100072062(PDSS2)
MDO: 
100024999(PDSS1)
SHR: 
100915254(PDSS2) 100919964(PDSS1)
OAA: 
100075316 100080833
GGA: 
420490(PDSS1) 421777(PDSS2)
MGP: 
100541404 100547515
TGU: 
100220588(PDSS2) 100226798(PDSS1)
ACS: 
100559597 100561155
XTR: 
493532(pdss2) 779676(pdss1)
DRE: 
436624(pdss2) 550349(pdss1)
TRU: 
101069121 101074637
OLA: 
101168998 101174393
BFO: 
BRAFLDRAFT_115262 BRAFLDRAFT_240454 BRAFLDRAFT_240460
CIN: 
100175803 100182797
SPU: 
576167 580561
DME: 
Dmel_CG10585 Dmel_CG31005(qless)
DPO: 
Dpse_GA10416 Dpse_GA15930
DAN: 
Dana_GF17201 Dana_GF24292
DER: 
Dere_GG11874 Dere_GG16155
DPE: 
Dper_GL13744 Dper_GL24462
DSE: 
Dsec_GM12094 Dsec_GM22336
DSI: 
Dsim_GD14926 Dsim_GD16491
DWI: 
Dwil_GK13098 Dwil_GK25396
DYA: 
Dyak_GE19723 Dyak_GE23254 Dyak_GE23324
DGR: 
Dgri_GH15641 Dgri_GH19601
DMO: 
Dmoj_GI12688 Dmoj_GI23994
DVI: 
Dvir_GJ12673 Dvir_GJ23628
AGA: 
AgaP_AGAP000591 AgaP_AGAP002069 AgaP_AGAP006015 AgaP_AGAP006016
AAG: 
AaeL_AAEL001732 AaeL_AAEL001740 AaeL_AAEL002287
CQU: 
CpipJ_CPIJ008090 CpipJ_CPIJ016311
AME: 
412735 551463
NVI: 
100118369(NV18793) 100119999(NV11656)
TCA: 
658669 662107
API: 
100167007 100168103
PHU: 
Phum_PHUM260230 Phum_PHUM287700
ISC: 
IscW_ISCW013145 IscW_ISCW013390
CEL: 
CELE_C24A11.9(coq-1)
CBR: 
CBG12314(Cbr-coq-1)
BMY: 
Bm1_35720
TSP: 
Tsp_06452 Tsp_08290
SMM: 
Smp_059800
NVE: 
NEMVE_v1g168669 NEMVE_v1g238335
HMG: 
100197234 100197374
TAD: 
TRIADDRAFT_20625 TRIADDRAFT_56502
AQU: 
100640178 100641366
 » show all
Taxonomy
Reference
1  [PMID:16262699]
  Authors
Saiki R, Nagata A, Kainou T, Matsuda H, Kawamukai M.
  Title
Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.
  Journal
FEBS. J. 272 (2005) 5606-22.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system