| Entry |
|
|---|
| Name |
tryptophan transaminase;
L-phenylalanine-2-oxoglutarate aminotransferase;
tryptophan aminotransferase;
5-hydroxytryptophan-ketoglutaric transaminase;
hydroxytryptophan aminotransferase;
L-tryptophan aminotransferase;
L-tryptophan transaminase |
|---|
| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
 |
|---|
| Sysname |
L-tryptophan:2-oxoglutarate aminotransferase |
|---|
| Reaction(IUBMB) |
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate
[RN:R00684] |
|---|
| Reaction(KEGG) |
R00684;
(other) R02700 R04913
 |
|---|
| Substrate |
L-tryptophan [CPD:C00078];
2-oxoglutarate [CPD:C00026] |
|---|
| Product |
(indol-3-yl)pyruvate [CPD:C00331];
L-glutamate [CPD:C00025] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. Also acts on 5-hydroxytryptophan and,
to a lesser extent, on the phenyl amino acids. |
|---|
| Pathway |
PATH: ec00380 Tryptophan metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5722279]
George H, Gabay S.
Brain aromatic aminotransferase. I. Purification and some properties
of pig brain L-phenylalanine-2-oxoglutarate aminotransferase.
Biochim. Biophys. Acta. 167 (1968) 555-66.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5697992]
O'Neil SR, DeMoss RD.
Tryptophan transaminase from Clostridium sporogenes.
Arch. Biochem. Biophys. 127 (1968) 361-9.
Clostridium sporogenes |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:14285270]
TANGEN O, FONNUM F, HAAVALDSEN R.
SEPARATION AND PURIFICATION OF AROMATIC AMINO ACID TRANSAMINASES
FROM RAT BRAIN.
Biochim. Biophys. Acta. 96 (1965) 82-90.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.6.1.27
IUBMB Enzyme Nomenclature: 2.6.1.27
ExPASy - ENZYME nomenclature database: 2.6.1.27
BRENDA, the Enzyme Database: 2.6.1.27
CAS: 9022-98-4 |
|---|
