KEGG   ENZYME: 2.6.1.34Help
Entry
EC 2.6.1.34                 Enzyme                                 

Name
UDP-N-acetylbacillosamine transaminase;
uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase;
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase;
UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase;
pglE (gene name);
UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
UDP-N-acetylbacillosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate [RN:R04529]
Reaction(KEGG)
Substrate
UDP-N-acetylbacillosamine [CPD:C04630];
2-oxoglutarate [CPD:C00026]
Product
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose [CPD:C04613];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme is involved in biosynthesis of UDP-N,N'-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [2-4] and O-linked glycosylation of certain L-serine residues in Neisseria species [5].
History
EC 2.6.1.34 created 1972, modified 2013
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K15910  
UDP-N-acetylbacillosamine transaminase
Genes
WSU: 
WS0037(wlaK)
SKU: 
CJE: 
Cj1121c(pglE)
CJB: 
CJJ: 
CJU: 
C8J_1062(wlaK)
CJN: 
CJI: 
CJSA_1063(pglE)
CJM: 
CJM1_1100(pglE)
CJS: 
CJP: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CJR: 
CJE1264(pglE)
CJD: 
CJZ: 
CJX: 
CFF: 
CFV: 
CAMP: 
CCV: 
CHA: 
CCO: 
CLA: 
Cla_1257(pglE)
CCOL: 
CCC: 
CCQ: 
 » show all
Taxonomy
Reference
1  [PMID:4381351]
  Authors
Distler J, Kaufman B, Roseman S.
  Title
Enzymic synthesis of a diamino sugar nucleotide by extracts of type XIV Diplococcus pneumoniae.
  Journal
Arch. Biochem. Biophys. 116 (1966) 466-78.
Reference
2  [PMID:17087520]
  Authors
Olivier NB, Chen MM, Behr JR, Imperiali B
  Title
In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.
  Journal
Biochemistry. 45 (2006) 13659-69.
Reference
3  [PMID:16286454]
  Authors
Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM
  Title
Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.
  Journal
J. Biol. Chem. 281 (2006) 723-32.
  Sequence
[cje:Cj1121c]
Reference
4  [PMID:18198901]
  Authors
Rangarajan ES, Ruane KM, Sulea T, Watson DC, Proteau A, Leclerc S, Cygler M, Matte A, Young NM
  Title
Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter  jejuni.
  Journal
Biochemistry. 47 (2008) 1827-36.
Reference
5  [PMID:21542610]
  Authors
Hartley MD, Morrison MJ, Aas FE, Borud B, Koomey M, Imperiali B
  Title
Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine.
  Journal
Biochemistry. 50 (2011) 4936-48.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37277-89-7

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