KEGG   ENZYME: 2.6.1.37Help
Entry
EC 2.6.1.37                 Enzyme                                 

Name
2-aminoethylphosphonate---pyruvate transaminase;
(2-aminoethyl)phosphonate transaminase;
(2-aminoethyl)phosphonate aminotransferase;
(2-aminoethyl)phosphonic acid aminotransferase;
2-aminoethylphosphonate-pyruvate aminotransferase;
2-aminoethylphosphonate aminotransferase;
2-aminoethylphosphonate transaminase;
AEP transaminase;
AEPT
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
(2-aminoethyl)phosphonate:pyruvate aminotransferase
Reaction(IUBMB)
(2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine [RN:R04152]
Reaction(KEGG)
Substrate
(2-aminoethyl)phosphonate [CPD:C03557];
pyruvate [CPD:C00022]
Product
2-phosphonoacetaldehyde [CPD:C03167];
L-alanine [CPD:C00041]
Comment
A pyridoxal-phosphate protein. 2-Aminoethylarsonate can replace 2-aminoethylphosphonate as a substrate.
History
EC 2.6.1.37 created 1972, modified 1982, modified 2001
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K03430  2-aminoethylphosphonate-pyruvate transaminase
Genes
STY: STY0470(phnW)
STT: t2432(phnW)
SEX: STBHUCCB_25720
SENT: TY21A_12340
STM: STM0431(phnW)
SEO: STM14_0510(phnW)
SEV: STMMW_05011
SEY: SL1344_0425(phnW)
SEM: STMDT12_C04950
SEJ: STMUK_0437(phnW)
SEB: STM474_0451(phnW)
SEF: UMN798_0474(phnW)
SENR: STMDT2_04271(phnW)
SEND: DT104_04761(phnW)
SENI: CY43_02495
SPT: SPA2292(phnW)
SEK: SSPA2134
SEI: SPC_0443(phnW)
SEC: SCH_0472(phnW)
SEH: SeHA_C0533(phnW)
SHB: SU5_01123
SEE: SNSL254_A0478(phnW)
SEW: SeSA_A0491(phnW)
SEA: SeAg_B0470(phnW)
SENS: Q786_02120
SED: SeD_A0472(phnW)
SEG: SG0442(phnW)
SEL: SPUL_2536(phnW)
SEGA: SPUCDC_2522(phnW)
SET: SEN0413(phnW)
SENA: AU38_02110
SENO: AU37_02105
SENV: AU39_02110
SENQ: AU40_02340
SENL: IY59_02160
SEEP: I137_11545
SENB: BN855_4280(phnW)
SENE: IA1_02305
KPN: KPN_04063(phnW)
KPU: KP1_5436(phnW)
KPP: A79E_0044
KPT: VK055_3402(phnW)
KPR: KPR_0043(phnW)
KPJ: N559_0077
KPX: PMK1_01569(phnW)
KPNU: LI86_00220
KPNK: BN49_0044(phnW)
KOX: KOX_06375
KOE: A225_5749
EAE: EAE_06835
EAR: CCG32639
KQV: B8P98_00210(phnW)
HDE: HDEF_0201
SRL: SOD_c30120(phnW1)
SMAF: D781_1947
SMW: SMWW4_v1c21470(phnW)
SMAR: SM39_1581(phnW)
SMAC: SMDB11_1393(phnW)
SERF: L085_18020
PRG: RB151_040700(phnW)
PALA: CO695_06440(phnW)
ETE: ETEE_2728(phnW)
XOO: XOO1391
XOM: XOO1279(XOO1279)
XAL: XALC_2366
VCH: VCA0604
VCE: Vch1786_II0289(phnW)
VCO: VC0395_0546(phnW)
VCR: VC395_A0711(phnW)
VCM: VCM66_A0562(phnW)
VCI: O3Y_16368
VCS: MS6_A0653
VCX: VAA049_2334(phnW)
VCZ: VAB027_560(phnW)
VVU: VV2_1664(phnW)
VVY: VVA0476
VPA: VPA0235
VAG: N646_3669
VHR: AL538_20895(phnW)
VDB: AL552_02090(phnW)
VSP: VS_II0398
VFL: AL536_03160(phnW)
VMI: AL543_04115(phnW)
PPR: PBPRA2204
PAE: PA1310(phnW)
PAEV: N297_1350(phnW)
PAEI: N296_1350(phnW)
PAU: PA14_47300(phnW)
PAP: PSPA7_4081(phnW)
PAG: PLES_38721(phnW)
PAF: PAM18_3593(phnW)
PNC: NCGM2_2196(phnW)
PAEB: NCGM1900_5263(phnW)
PAEP: PA1S_19355
PAEM: U769_19200
PAEL: T223_19805
PAEU: BN889_01412(phnW)
PAEG: AI22_15245
PAEC: M802_1347(phnW)
PAEO: M801_1349(phnW)
PRE: PCA10_07760(phnW)
PCQ: PcP3B5_33850(phnW)
PPU: PP_2209(phnW)
PPF: Pput_3529
PPT: PPS_1820
PPI: YSA_01367
PPX: T1E_0554
PPUH: B479_08990
PPUT: L483_08845
PPUN: PP4_36060(phnW)
PPUD: DW66_2068
PMON: X969_06935
PMOT: X970_06910
PFL: PFL_3965(phnW)
PPRC: PFLCHA0_c40240(phnW)
PPRO: PPC_4064(phnW)
PFS: PFLU_3911
PFC: PflA506_3286(phnW)
PFW: PF1751_v1c33490(phnW)
PFB: VO64_0989
PMAN: OU5_0005 OU5_1264(phnW)
PEN: PSEEN3553(phnW)
PPUU: PputUW4_01746(phnW1) PputUW4_02575(phnW2)
PKC: PKB_3137(phnW)
PSEM: TO66_20545
PSEC: CCOS191_1693(phnW)
PSOS: POS17_4074(phnW)
PANR: A7J50_3572
PSET: THL1_826
ACB: A1S_1364
ABY: ABAYE2318(phnW)
ABN: AB57_1572
ABB: ABBFA_002147(phnW)
ABX: ABK1_1827
ABH: M3Q_1738
ABAZ: P795_10495
ABAU: IX87_03570
ABAA: IX88_08670
ACC: BDGL_000722(phnW)
SDN: Sden_1165
SPSW: Sps_04129
PSEO: OM33_17365
PPIS: B1L02_15010(phnW)
PSPO: PSPO_b1181(phnW)
PTU: PTUN_b0259(phnW)
MHC: MARHY1153(phnW)
MBS: MRBBS_3417(phnW)
PIN: Ping_2747
MVS: MVIS_0354(phnW)
NOC: Noc_1315
NHL: Nhal_1304
NWA: Nwat_1197
HCH: HCH_03085
HAM: HALO0563
HBE: BEI_2638(phnW)
OAI: OLEAN_C33590(phnW)
AHA: AHA_1938(phnW)
AVR: B565_1685
ADH: CK627_16360(phnW)
ACAV: VI35_09520(phnW)
OCE: GU3_01365
REH: H16_B1953(h16_B1953)
CNC: CNE_2c19160(phnW)
RME: Rmet_1810(phnW)
CGD: CR3_4149(phnW)
BMA: BMAA0852 BMAA1770(phnW)
BMAL: DM55_4012
BMAE: DM78_3998(phnW)
BMAQ: DM76_4708
BMAF: DM51_3463 DM51_4548(phnW)
BMAZ: BM44_3972 BM44_4878(phnW)
BMAB: BM45_3780(phnW) BM45_4749
BPSE: BDL_3575(phnW) BDL_3733
BPSM: BBQ_5689 BBQ_5856(phnW)
BPSU: BBN_3739(phnW) BBN_3907
BPSD: BBX_5413(phnW) BBX_5570
BPK: BBK_5555(phnW) BBK_5712
BPSH: DR55_4845 DR55_5004(phnW)
BPSA: BBU_5540 BBU_5774(phnW)
BPSO: X996_4595 X996_4773(phnW)
BUT: X994_4113 X994_4273(phnW)
BTQ: BTQ_5192 BTQ_5335(phnW)
BTJ: BTJ_3822 BTJ_3987(phnW)
BTZ: BTL_4678 BTL_4811(phnW)
BTD: BTI_4387(phnW) BTI_5336
BTV: BTHA_5419(phnW) BTHA_5551
BTHE: BTN_4317 BTN_4461(phnW)
BTHM: BTRA_4582 BTRA_4726(phnW)
BTHL: BG87_4649 BG87_4792(phnW)
BVE: AK36_3210(phnW) AK36_4234
BCEN: DM39_3248(phnW) DM39_3755 DM39_5338(phnW)
BCEW: DM40_3151(phnW) DM40_4161
BMJ: BMULJ_00091(phnW)
BMK: DM80_1716(phnW) DM80_3634 DM80_4805(phnW)
BMUL: NP80_118(phnW) NP80_4146 NP80_5127(phnW)
BCED: DM42_1812(phnW) DM42_3848 DM42_5475(phnW)
BDL: AK34_3330(phnW) AK34_4232
BUB: BW23_3720(phnW) BW23_4917
BGP: BGL_2c04810(phnW1) BGL_2c11750 BGL_2c20320(phnW2)
BGU: KS03_4593 KS03_5531(phnW)
BGO: BM43_4190(phnW) BM43_5001
BUE: BRPE67_ACDS06770(phnW)
BUL: BW21_3920(phnW) BW21_5016
BXB: DR64_4271(phnW) DR64_4564 DR64_7186(phnW)
BFN: OI25_3688(phnW) OI25_4334(phnW) OI25_4866(phnW)
AXY: AXYL_00877(phnW)
AXX: ERS451415_00878(phnW)
VEI: Veis_0967
LIM: L103DPR2_01223(phnW)
CFU: CFU_0632(phnW)
CARE: LT85_0692
CPRA: CPter91_0742(phnW)
RGE: RGE_31460(phnW)
SMUL: SMUL_2960(phnW)
DGG: DGI_0774
SCL: sce4777(phnW)
SFU: Sfum_2895
SME: SM_b21537
SMI: BN406_05687(phnW)
SMEL: SM2011_b21537(phnW)
SMER: DU99_28550
SMD: Smed_4874
SIX: BSY16_5629(phnW)
ARA: Arad_7867(phnW)
SHZ: shn_14575
BJA: blr2077
RPC: RPC_3872
OAT: OAN307_c30560(phnW)
RHC: RGUI_0660
GXL: H845_1625
MAGX: XM1_0897(phnW)
AZL: AZL_a10490(phnW)
BAN: BA_1341
BAR: GBAA_1341
BAT: BAS1240
BAI: BAA_1408
BANT: A16_13850
BANR: A16R_14040
BANS: BAPAT_1259
BANV: DJ46_166(phnW)
BCE: BC1327
BCA: BCE_1440
BCZ: BCE33L1218(phnW)
BCQ: BCQ_1399(phnW)
BCX: BCA_1379
BAL: BACI_c13610(phnW)
BNC: BCN_1300
BCF: bcf_06715
BCER: BCK_01755
BTK: BT9727_1216(phnW)
BTL: BALH_1190(phnW)
BTT: HD73_1556
BTHI: BTK_07925
BTM: MC28_0555(phnW)
BTG: BTB_c13700(phnW)
BTI: BTG_14110
BTW: BF38_2546(phnW)
BWW: bwei_3682(phnW)
BMYO: BG05_4572(phnW)
BMQ: BMQ_3212(phnW)
BMD: BMD_3230(phnW)
BMH: BMWSH_4462(aepZ)
BMEG: BG04_3080
BEO: BEH_01670
BKO: CKF48_21270(phnW)
LSP: Bsph_1360
LYS: LBYS11_04085(phnW)
LYB: C3943_05150(phnW)
SCA: SCA_0878
BBE: BBR47_44970(phnW)
PPOL: X809_41420
PMS: KNP414_00884(phnW)
PMW: B2K_03970
PSWU: SY83_08025
PDH: B9T62_17300(phnW)
KYR: CVV65_06375(phnW)
KUR: ASO14_1515(phnW)
LPL: lp_0710(phnW)
LPJ: JDM1_0586(phnW)
LPT: zj316_0778(phnW)
LPS: LPST_C0541(phnW)
LPZ: Lp16_0560
EFU: HMPREF0351_11688(phnW)
EFM: M7W_1185
EMU: EMQU_1818(phnW)
CBL: CLK_1504
CBE: Cbei_4336
CBZ: Cbs_4336
CBEI: LF65_04860
CSR: Cspa_c46170(phnW)
CBV: U729_678(phnW)
CSO: CLS_31060
EAC: EAL2_c21220(phnW)
ELM: ELI_2328
EHL: EHLA_0402
BPRM: CL3_22330
PFT: JBW_03191
KSK: KSE_22700
BSCA: BBSC_0730
ELE: Elen_2312
OLS: Olsu_0595
CAP: CLDAP_13850(phnW)
OBG: Verru16b_03223(phnW)
AGL: PYTT_0872
PSL: Psta_3135
IPA: Isop_0932
TDE: TDE1415
BIP: Bint_1241
FVA: FV113G1_24060(phnW)
BFR: BF3695
BVU: BVU_3006
BOA: Bovatus_01972(phnW)
BCEL: BcellWH2_05389(phnW)
PDI: BDI_2851
PARC: CI960_20510(phnW)
AALG: AREALGSMS7_02095(phnW)
NDE: NIDE0734(phnW)
NMV: NITMOv2_0603(phnW)
NIO: NITINOP_0315(phnW)
NJA: NSJP_1715(phnW)
 » show all
Taxonomy
Reference
1  [PMID:4982500]
  Authors
La Nauze JM, Rosenberg H.
  Title
The identification of 2-phosphonoacetaldehyde as an intermediate in the degradation of 2-aminoethylphosphonate by Bacillus cereus.
  Journal
Biochim. Biophys. Acta. 165 (1968) 438-47.
Reference
2  [PMID:6406228]
  Authors
Dumora C, Lacoste AM, Cassaigne A.
  Title
Purification and properties of 2-aminoethylphosphonate:pyruvate aminotransferase from Pseudomonas aeruginosa.
  Journal
Eur. J. Biochem. 133 (1983) 119-25.
  Sequence
[pae:PA1310]
Reference
3  [PMID:8394813]
  Authors
Lacoste AM, Dumora C, Balas L, Hammerschmidt F, Vercauteren J.
  Title
Stereochemistry of the reaction catalysed by 2-aminoethylphosphonate aminotransferase. A 1H-NMR study.
  Journal
Eur. J. Biochem. 215 (1993) 841-4.
  Sequence
[pae:PA1310]
Reference
4  [PMID:1527499]
  Authors
Lacoste AM, Dumora C, Ali BR, Neuzil E, Dixon HB.
  Title
Utilization of 2-aminoethylarsonic acid in Pseudomonas aeruginosa.
  Journal
J. Gen. Microbiol. 138 (1992) 1283-7.
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.37
IUBMB Enzyme Nomenclature: 2.6.1.37
ExPASy - ENZYME nomenclature database: 2.6.1.37
BRENDA, the Enzyme Database: 2.6.1.37
CAS: 37277-91-1

DBGET integrated database retrieval system