| Entry |
|
|---|
| Name |
tyrosine transaminase;
tyrosine aminotransferase;
glutamic-hydroxyphenylpyruvic transaminase;
glutamic phenylpyruvic aminotransferase;
L-phenylalanine 2-oxoglutarate aminotransferase;
L-tyrosine aminotransferase;
phenylalanine aminotransferase;
phenylalanine transaminase;
phenylalanine-alpha-ketoglutarate transaminase;
phenylpyruvate transaminase;
phenylpyruvic acid transaminase;
tyrosine-alpha-ketoglutarate aminotransferase;
tyrosine-alpha-ketoglutarate transaminase;
tyrosine-2-ketoglutarate aminotransferase;
TyrAT |
|---|
| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
 |
|---|
| Sysname |
L-tyrosine:2-oxoglutarate aminotransferase |
|---|
| Reaction(IUBMB) |
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
[RN:R00734] |
|---|
| Reaction(KEGG) |
R00734;
(other) R00694 R07396
 |
|---|
| Substrate |
L-tyrosine [CPD:C00082];
2-oxoglutarate [CPD:C00026] |
|---|
| Product |
4-hydroxyphenylpyruvate [CPD:C01179];
L-glutamate [CPD:C00025] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. L-Phenylalanine can act instead of
L-tyrosine. The mitochondrial enzyme may be identical with EC
2.6.1.1 (aspartate transaminase). The three isoenzymic forms are
interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33
(fruit bromelain). The enzyme can also catalyse the final step in
the methionine-salvage pathway of Klebsiella pneumoniae [8]. |
|---|
| Pathway |
PATH: ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
PATH: ec00270 Cysteine and methionine metabolism
PATH: ec00350 Tyrosine metabolism
PATH: ec00360 Phenylalanine metabolism
PATH: ec00400 Phenylalanine, tyrosine and tryptophan biosynthesis
PATH: ec00401 Novobiocin biosynthesis
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01064 Biosynthesis of alkaloids derived from ornithine,
lysine and nicotinic acid
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00815 tyrosine aminotransferase |
|---|
| Genes |
HSA: 6898(TAT)
PTR: 454227(TAT)
MCC: 708005(TAT)
MMU: 234724(Tat)
RNO: 24813(Tat)
CFA: 479665(TAT)
BTA: 533481(TAT)
ECB: 100068116
MDO: 100020832
OAA: 100077699
GGA: 415884(TAT)
TGU: 100230394
XTR: 448486(tat)
DRE: 561410(tat)
BFO: BRAFLDRAFT_275580
CIN: 100183684
SPU: 592114
DME: Dmel_CG1461
DPO: Dpse_GA13109
DAN: Dana_GF22556
DER: Dere_GG17840
DPE: Dper_GL14927
DSE: Dsec_GM17670
DSI: Dsim_GD17166
DYA: Dyak_GE17134
DGR: Dgri_GH12929
DMO: Dmoj_GI15439
AGA: AgaP_AGAP000327
AAG: AaeL_AAEL008963
CQU: CpipJ_CPIJ003774
AME: 725204
NVI: 100119866
TCA: 659321
ISC: IscW_ISCW014463
CEL: F42D1.2
CBR: CBG07591
BMY: Bm1_31005
NVE: NEMVE_v1g207788
HMG: 100204677
TAD: TRIADDRAFT_35383
ATH: AT5G36160 AT5G53970
POP: POPTR_568851(AMT7) POPTR_594645(AMT6)
RCU: RCOM_0651460 RCOM_1173140
VVI: 100241782(GSVIVT00027735001) 100242005(GSVIVT00018628001)
100253895(GSVIVT00018632001)
OSA: 4329098(Os02g0302400) 4329101(Os02g0302700)
SBI: SORBI_03g026220(SORBIDRAFT_03g026220)
SORBI_05g021610(SORBIDRAFT_05g021610)
SORBI_08g000600(SORBIDRAFT_08g000600)
ZMA: 100193424 100279205
PPP: PHYPADRAFT_215944
OLU: OSTLU_3820
CME: CMT533C
DDI: DDB_0230996(tat)
TET: TTHERM_00046180 TTHERM_00554320 TTHERM_00683360
PTM: GSPATT00003669001
TCR: 508535.50 510187.20 510187.30 510187.40 510187.50 510187.70
510795.10 511461.20
LMA: LmjF36.2360
LIF: LinJ36.4910
LBZ: LbrM35_V2.2580
PTI: PHATR_51609
TPS: THAPSDRAFT_268594
 |
|---|
| Structures |
PDB: 1BW0 3DYD |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13366978]
CANELLAKIS ZN, COHEN PP.
Purification studies of tyrosine-alpha-ketoglutaric acid
transaminase.
J. Biol. Chem. 222 (1956) 53-62.
Canis familiaris [GN:cfa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13366979]
CANELLAKIS ZN, COHEN PP.
Kinetic and substrate specificity study of
tyrosine-alpha-ketoglutaric acid transaminase.
J. Biol. Chem. 222 (1956) 63-71.
Canis familiaris [GN:cfa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:14171223]
JACOBY GA, LADU BN.
STUDIES ON THE SPECIFICITY OF TYROSINE-ALPHA-KETOGLUTARATE
TRANSAMINASE.
J. Biol. Chem. 239 (1964) 419-24.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:14408534]
KENNEY FT.
Properties of partially purified tyrosine-alpha-ketoglutarate
transaminase from rat liver.
J. Biol. Chem. 234 (1959) 2707-12.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:4396841]
Miller JE, Litwack G.
Purification, properties, and identity of liver mitochondrial
tyrosine aminotransferase.
J. Biol. Chem. 246 (1971) 3234-40.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:13363833]
ROWSELL EV.
Transaminations with L-glutamate and alpha-oxoglutarate in fresh
extracts of animal tissues.
Biochem. J. 64 (1956) 235-45.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
7 [PMID:13750129]
SENTHESHANMUGANATHAN S.
The purification and properties of the tyrosine-2-oxoglutarate
transaminase of Saccharomyces cerevisiae.
Biochem. J. 77 (1960) 619-25.
Canis familiaris [GN:cfa], Saccharomyces cerevisiae [GN:sce] |
|---|
Reference
Authors
Title
Journal
Organism
|
8 [PMID:10074065]
Heilbronn J, Wilson J, Berger BJ.
Tyrosine aminotransferase catalyzes the final step of methionine
recycling in Klebsiella pneumoniae.
J. Bacteriol. 181 (1999) 1739-47.
Klebsiella pneumoniae [GN:kpn] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.6.1.5
IUBMB Enzyme Nomenclature: 2.6.1.5
ExPASy - ENZYME nomenclature database: 2.6.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 2.6.1.5
BRENDA, the Enzyme Database: 2.6.1.5
CAS: 9014-55-5 |
|---|
