| Entry |
|
|---|
| Name |
serine---pyruvate transaminase;
SPT;
hydroxypyruvate:L-alanine transaminase |
|---|
| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
 |
|---|
| Sysname |
L-serine:pyruvate aminotransferase |
|---|
| Reaction(IUBMB) |
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine [RN:R00585] |
|---|
| Reaction(KEGG) |
R00585
 |
|---|
| Substrate |
L-serine [CPD:C00065];
pyruvate [CPD:C00022] |
|---|
| Product |
3-hydroxypyruvate [CPD:C00168];
L-alanine [CPD:C00041] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. The liver enzyme may be identical
with EC 2.6.1.44 alanine-glyoxylate transaminase. |
|---|
| Pathway |
PATH: ec00260 Glycine, serine and threonine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00830 alanine--glyoxylate transaminase / serine--pyruvate
aminotransferase
KO: K13290 alanine-glyoxylate transaminase / serine-glyoxylate
transaminase / serine-pyruvate transaminase |
|---|
| Genes |
HSA: 189(AGXT)
MCC: 699941(AGXT)
MMU: 11611(Agxt)
RNO: 24792(Agxt)
CFA: 607355(AGXT)
BTA: 789572(AGXT)
ECB: 100067459
OAA: 100080454
ATH: AT2G13360(AGT)
POP: POPTR_815301
RCU: RCOM_0063050
VVI: 100261927(GSVIVT00022240001)
OSA: 4345962(Os08g0502700)
SBI: SORBI_07g028080(SORBIDRAFT_07g028080)
ZMA: 100281949(pco084394)
PPP: PHYPADRAFT_176699
CRE: CHLREDRAFT_194609(SGA1a|SGA1b)
CME: CMS429C
DDI: DDB_0237978(agxt)
 |
|---|
| Structures |
PDB: 1J04 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5699148]
Cheung GP, Rosenblum IY, Sallach HJ.
Comparative studies of enzymes related to serine metabolism in
higher plants.
Plant. Physiol. 43 (1968) 1813-20.
Pisum sativum |
|---|
Reference
Authors
Title
Journal
|
2
Kretovich, V.L. and Stepanovich, K.M.
[The synthesis of serine from hydroxypyruvate in plants.].
Dokl. Akad. Nauk S.S.S.R. 139 (1961) 488-490. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13385257]
SALLACH HJ.
Formation of serine hydroxypryuvate and L-alanine.
J. Biol. Chem. 223 (1956) 1101-8.
Canis familiaris [GN:cfa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.6.1.51
IUBMB Enzyme Nomenclature: 2.6.1.51
ExPASy - ENZYME nomenclature database: 2.6.1.51
BRENDA, the Enzyme Database: 2.6.1.51
CAS: 9030-88-0 |
|---|
