| Entry |
|
|---|
| Name |
leucine transaminase;
L-leucine aminotransferase;
leucine 2-oxoglutarate transaminase;
leucine aminotransferase;
leucine-alpha-ketoglutarate transaminase |
|---|
| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
 |
|---|
| Sysname |
L-leucine:2-oxoglutarate aminotransferase |
|---|
| Reaction(IUBMB) |
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
[RN:R01090] |
|---|
| Reaction(KEGG) |
R01090;
(other) R01214
 |
|---|
| Substrate |
L-leucine [CPD:C00123];
2-oxoglutarate [CPD:C00026] |
|---|
| Product |
4-methyl-2-oxopentanoate [CPD:C00233];
L-glutamate [CPD:C00025] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. This enzyme differs from EC 2.6.1.42,
branched-chain-amino-acid transaminase, in that it does not act on
L-valine or L-isoleucine, although it does act on L-methionine. The
mitochondrial form from rat liver differs in physical
characteristics from the cytoplasmic form. |
|---|
| Pathway |
PATH: ec00280 Valine, leucine and isoleucine degradation
PATH: ec00290 Valine, leucine and isoleucine biosynthesis
PATH: ec00770 Pantothenate and CoA biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4968655]
Aki K, Ogawa K, Ichihara A.
Transaminases of branched chain amino acids. IV. Purification and
properties of two enzymes from rat liver.
Biochim. Biophys. Acta. 159 (1968) 276-84.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:974100]
Ikeda T, Konishi Y, Ichihara A.
Transaminase of branched chain amino acids. XI. Leucine (methionine)
transaminase of rat liver mitochondria.
Biochim. Biophys. Acta. 445 (1976) 622-31.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.6.1.6
IUBMB Enzyme Nomenclature: 2.6.1.6
ExPASy - ENZYME nomenclature database: 2.6.1.6
BRENDA, the Enzyme Database: 2.6.1.6
CAS: 9030-37-9 |
|---|
