| Entry |
|
|---|
| Name |
kynurenine---oxoglutarate transaminase;
kynurenine transaminase (cyclizing);
kynurenine 2-oxoglutarate transaminase;
kynurenine aminotransferase;
L-kynurenine aminotransferase |
|---|
| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
 |
|---|
| Sysname |
L-kynurenine:2-oxoglutarate aminotransferase |
|---|
| Reaction(IUBMB) |
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate
+ L-glutamate [RN:R01956] |
|---|
| Reaction(KEGG) |
R01956;
(other) R04171
 |
|---|
| Substrate |
L-kynurenine [CPD:C00328];
2-oxoglutarate [CPD:C00026] |
|---|
| Product |
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:C01252];
L-glutamate [CPD:C00025] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The
product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into
kynurenate by a spontaneous reaction. |
|---|
| Pathway |
PATH: ec00380 Tryptophan metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00816 kynurenine-oxoglutarate transaminase |
|---|
| Genes |
HSA: 51166(AADAT)
PTR: 461601(AADAT) 473069(CCBL1)
MCC: 717142(CCBL1)
MMU: 23923(Aadat) 70266(Ccbl1)
RNO: 29416(Aadat) 311844(Ccbl1)
CFA: 486059(AADAT) 491310(CCBL1)
BTA: 508929(AADAT) 520638(AADAT)
SSC: 100152011
ECB: 100067095
MDO: 100031005
OAA: 100076580
GGA: 428728(AADAT)
TGU: 100228964
XLA: 398787
XTR: 496662
DRE: 557979
CIN: 100175167
AME: 724239
TCA: 662228
MGR: MGG_14221
UMA: UM03538.1
DDI: DDBDRAFT_0187583
 |
|---|
| Structures |
PDB: 1X0M 1YIY 1YIZ 2QLR 2R2N 2R5C 2R5E 2VGZ 2ZJG 3DC1
3E2F 3E2Y 3E2Z 3FVS 3FVU 3FVX |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13357462]
BONNER DM, JAKOBY WB.
Kynurenine transaminase from neurospora.
J. Biol. Chem. 221 (1956) 689-95.
Neurospora crassa [GN:ncr] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13449053]
MASON M.
Kynurenine transaminase of rat kidney; a study of coenzyme
dissociation.
J. Biol. Chem. 227 (1957) 61-8.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.6.1.7
IUBMB Enzyme Nomenclature: 2.6.1.7
ExPASy - ENZYME nomenclature database: 2.6.1.7
BRENDA, the Enzyme Database: 2.6.1.7
CAS: 9030-38-0 |
|---|
