KEGG   ENZYME: 2.6.1.7Help
Entry
EC 2.6.1.7                  Enzyme                                 

Name
kynurenine---oxoglutarate transaminase;
kynurenine transaminase (cyclizing);
kynurenine 2-oxoglutarate transaminase;
kynurenine aminotransferase;
L-kynurenine aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-kynurenine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate [RN:R01956]
Reaction(KEGG)
R01956;
(other) R04171
Show
Substrate
L-kynurenine [CPD:C00328];
2-oxoglutarate [CPD:C00026]
Product
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:C01252];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
History
EC 2.6.1.7 created 1961, modified 1983
Pathway
Tryptophan metabolism
Metabolic pathways
Orthology
K00816  
kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase
K00825  
kynurenine/2-aminoadipate aminotransferase
K14264  
kynurenine aminotransferase
Genes
HSA: 
51166(AADAT) 56267(KYAT3) 883(KYAT1)
PTR: 
456999(KYAT3) 461601(AADAT) 473069(KYAT1)
PPS: 
100980672(KYAT1) 100993985(KYAT3) 100995091(AADAT)
GGO: 
101128027(KYAT3) 101137144(KYAT1) 101151419(AADAT)
PON: 
100435746(AADAT) 100436953(KYAT3) 100452866(KYAT1)
NLE: 
100579800(KYAT3) 100584784(AADAT) 100598335(KYAT1)
MCC: 
694023(KYAT3) 695264(AADAT) 717142(KYAT1)
MCF: 
101925086(KYAT3) 102122792(AADAT) 102142392(KYAT1)
CSAB: 
103224481(KYAT3) 103236521(AADAT) 103239781(KYAT1)
RRO: 
104660517(KYAT1) 104662870(AADAT) 104664603(KYAT3)
CJC: 
100390682(KYAT1) 100392205(KYAT3) 100403876(AADAT)
SBQ: 
101034905(CCBL1) 101047103(AADAT) 101049363(CCBL2)
MMU: 
229905(Kyat3) 23923(Aadat) 70266(Kyat1)
RNO: 
29416(Aadat) 311844(Kyat1) 541589(Kyat3)
CGE: 
NGI: 
103727134(Aadat) 103730106(Kyat3) 103742867(Kyat1)
HGL: 
101701445(Kyat3) 101707012(Aadat) 101714047(Ccbl1)
OCU: 
100351221(KYAT1) 100355602(AADAT) 100358799(KYAT3)
TUP: 
102479498(AADAT) 102484200(KYAT3) 102492301(KYAT1)
CFA: 
479959(KYAT3) 486059(AADAT) 491310(KYAT1)
AML: 
100466080(KYAT3) 100469458(AADAT) 100484335(KYAT1)
UMR: 
103658154(AADAT) 103662922(KYAT3) 103670433(KYAT1)
FCA: 
101082171(KYAT3) 101082605(KYAT1) 101091616(AADAT)
PTG: 
102949681(AADAT) 102956075(KYAT1) 102960707(KYAT3)
AJU: 
106966305(KYAT1) 106968046(KYAT3) 106985264(AADAT)
BTA: 
104968656(KYAT1) 508712(KYAT3) 508929(AADAT) 520638 528582(CCBL1)
BOM: 
PHD: 
CHX: 
102180605(KYAT1) 102182368(KYAT3) 102190411(AADAT)
OAS: 
101117485(KYAT1) 101119265(KYAT3) 101121661(AADAT)
SSC: 
100152011(AADAT) 100157176(KYAT3) 100515071(KYAT1)
CFR: 
102514713(KYAT1) 102515842(AADAT) 102522240(KYAT3)
BACU: 
103001193(KYAT3) 103002075(AADAT) 103002354 103010164(KYAT1)
LVE: 
103071573 103073927(KYAT1) 103077196(AADAT) 103090268(KYAT3)
ECB: 
100052141(KYAT3) 100067095(AADAT) 100070151(KYAT1)
MYB: 
102246710(KYAT1) 102246937(KYAT3) 102255657(AADAT)
MYD: 
102764566(AADAT) 102770113(KYAT1) 102774189(KYAT3)
HAI: 
PALE: 
102885606(KYAT3) 102886879(AADAT) 102890346(KYAT1)
LAV: 
100653952(AADAT) 100674418(KYAT1) 100676040(KYAT3)
MDO: 
SHR: 
100913887(AADAT) 100925132(KYAT1) 100928200(KYAT3)
OAA: 
100074153(CCBL1) 100074828(KYAT3) 100076580(AADAT)
GGA: 
417202(CCBL1) 424517(KYAT3) 428728(AADAT)
MGP: 
100539859(AADAT) 100545698(KYAT1) 100546759(KYAT3)
CJO: 
107313054(AADAT) 107317420(KYAT3) 107321728(KYAT1)
APLA: 
101796959(KYAT3) 101797673(AADAT) 101804188(KYAT1)
TGU: 
100223564(KYAT3) 100226378(KYAT1) 100228964(AADAT)
GFR: 
102038773(AADAT) 102043066(KYAT3) 102045568(KYAT1)
FAB: 
101809203(KYAT1) 101816765(KYAT3) 101817402(AADAT)
PHI: 
102108384(KYAT3) 102109435(KYAT1) 102114032(AADAT)
CCW: 
104688281(KYAT1) 104690544(AADAT) 104695321(KYAT3)
FPG: 
101916601(AADAT) 101923826(KYAT3) 101924602(KYAT1)
FCH: 
102052592(KYAT1) 102055107(KYAT3) 102059338(AADAT)
CLV: 
102087961(AADAT) 102092812(KYAT3) 102097970(KYAT1)
AAM: 
106484015(AADAT) 106490298(KYAT1) 106499802(KYAT3)
ASN: 
AMJ: 
102564187(KYAT1) 102573373(AADAT) 102574637(KYAT3)
PSS: 
102443615 102446036(KYAT1) 102459761(KYAT3) 102463594(AADAT)
CMY: 
102931085(KYAT1) 102933210(AADAT) 102947846(KYAT3)
CPIC: 
101933473(AADAT) 101948590(KYAT3) 101949101 101949140(KYAT1)
ACS: 
PBI: 
103050097(AADAT) 103054557(KYAT3) 103058068(KYAT1)
GJA: 
107107125(AADAT) 107107127 107115481(KYAT1) 107126241(KYAT3)
XLA: 
108715667(kyat3.S) 380432(kyat3.L) 398787(aadat.L) 432067(aadat.S) 734936(kyat1.L)
XTR: 
496662(aadat) 496736(kyat1)
DRE: 
100332215 393315(ccbl2) 557979(aadat) 791592(ccbl1)
IPU: 
TRU: 
101064758(kyat1) 101066451(kyat3) 101078353(aadat)
TNG: 
LCO: 
104931917(kyat3) 104938006(aadat) 104939087(kyat1)
MZE: 
101466800(kyat1) 101486988(ccbl2) 101487147(aadat)
OLA: 
101156284(aadat) 101164171(kyat1) 101173380(kyat3)
XMA: 
102227156 102233774(aadat) 102235261(kyat3) 102237088(kyat1)
SASA: 
LCM: 
102348380(KYAT1) 102363875(AADAT) 102366870(KYAT3)
CMK: 
103171755(kyat1) 103174679(kyat3) 103180238(aadat)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD20629(Dsim_GD20629)
DWI: 
DYA: 
Dyak_GE10079(dyak_GLEANR_10037)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
724239(GB10285) 724811(GB15834) 725529(GB19755)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_F28H6.3(nkat-1) CELE_R03A10.4(nkat-3)
CBR: 
CBG07704(Cbr-nkat-3) CBG10259
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
SCE: 
YJL060W(BNA3)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A09200(NCAS0A09200)
NDI: 
NDAI_0G05760(NDAI0G05760)
TPF: 
TPHA_0O01450(TPHA0O01450)
TDL: 
TDEL_0D01900(TDEL0D01900)
KAF: 
KAFR_0A01710(KAFR0A01710)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NCU03347(nic-4)
NTE: 
NEUTE1DRAFT84478(NEUTE1DRAFT_84478)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1964154(AO090003001103)
ANG: 
ANI_1_908184(An04g05490)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT38406(AGABI1DRAFT_38406)
ABV: 
AGABI2DRAFT67810(AGABI2DRAFT_67810)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
ACAN: 
TET: 
PTM: 
SMIN: 
v1.2.018754.t1(symbB.v1.2.018754.t1)
PTI: 
TPS: 
AAF: 
NGD: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
TBR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:13357462]
  Authors
BONNER DM, JAKOBY WB.
  Title
Kynurenine transaminase from neurospora.
  Journal
J. Biol. Chem. 221 (1956) 689-95.
Reference
2  [PMID:13449053]
  Authors
MASON M.
  Title
Kynurenine transaminase of rat kidney; a study of coenzyme dissociation.
  Journal
J. Biol. Chem. 227 (1957) 61-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-38-0

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