KEGG   ENZYME: 2.6.1.86Help
Entry
EC 2.6.1.86                 Enzyme                                 

Name
2-amino-4-deoxychorismate synthase;
ADIC synthase;
2-amino-2-deoxyisochorismate synthase;
SgcD
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
(2S)-2-amino-4-deoxychorismate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine [RN:R08956]
Reaction(KEGG)
Substrate
(2S)-2-amino-4-deoxychorismate [CPD:C18054];
L-glutamate [CPD:C00025]
Product
chorismate [CPD:C00251];
L-glutamine [CPD:C00064]
Comment
Requires Mg2+. The reaction occurs in the reverse direction to that shown above. In contrast to most anthranilate-synthase I (ASI) homologues, this enzyme is not inhibited by tryptophan. In Streptomyces globisporus, the sequential action of this enzyme and EC 1.3.99.24, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]. In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity [3,4].
History
EC 2.6.1.86 created 2008
Orthology
K13063  
phenazine biosynthesis protein phzE
Genes
ECA: 
ECA2701(ehpC)
PATR: 
PAE: 
PA1903(phzE2) PA4214(phzE1)
PAEV: 
PAEI: 
PAU: 
PA14_09440(phzE1)
PAP: 
PAG: 
PLES_07131(phzE1) PLES_34211(phzE2)
PAF: 
PAM18_0723(phzE1) PAM18_3139(phzE2)
PNC: 
NCGM2_2820(phzE2) NCGM2_5459(phzE2)
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
BN889_06971(phzE1_4) BN889_07067(phzE1_7) BN889_07250(phzE1_9)
PAEG: 
PAEC: 
PAEO: 
PCH: 
BUR: 
BGL: 
MAB: 
MABB: 
MMV: 
NBR: 
SCO: 
SCO2117(SC6E10.11)
SMA: 
SAV_6084(phzE)
SGR: 
SCB: 
SSX: 
SVL: 
SCT: 
SCAT_1246(phzB)
SCY: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SDV: 
SALB: 
STRP: 
SFI: 
SCI: 
SRC: 
SLV: 
KSK: 
MTS: 
KSE: 
NCA: 
NDA: 
FRE: 
FAL: 
KRA: 
KAL: 
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
AMS: 
ASE: 
ACPL_1962(phzE)
ACTN: 
AFS: 
CAI: 
 » show all
Taxonomy
Reference
1  [PMID:18182490]
  Authors
Van Lanen SG, Lin S, Shen B.
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 494-9.
  Sequence
[up:Q8GMH4]
Reference
2
  Authors
Yu, L., Mah, S., Otani, T. and Dedon, P.
  Title
The benzoxazolinate of C-1027 confers intercalative DNA binding.
  Journal
J. Am. Chem. Soc. 117 (1995) 8877-8878.
Reference
3  [PMID:11562236]
  Authors
McDonald M, Mavrodi DV, Thomashow LS, Floss HG.
  Title
Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid.
  Journal
J. Am. Chem. Soc. 123 (2001) 9459-60.
Reference
4  [PMID:15008629]
  Authors
Laursen JB, Nielsen J.
  Title
Phenazine natural products: biosynthesis, synthetic analogues, and biological activity.
  Journal
Chem. Rev. 104 (2004) 1663-86.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system