pyridoxine 5'-phosphate synthase;
pyridoxine 5-phosphate phospho lyase;
PNP synthase;
PdxJ

Transferases;
Transferring nitrogenous groups;
Transferring other nitrogenous groups

1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing)

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O [RN:R05838]

R05838

1-deoxy-D-xylulose 5-phosphate [CPD:C11437];
3-amino-2-oxopropyl phosphate [CPD:C11638]

In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate). 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate [3].

1  [PMID:12686115]

Garrido-Franco M.

Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond.

Biochim. Biophys. Acta. 1647 (2003) 92-7.

Escherichia coli [GN:eco]

2  [PMID:12206776]

Garrido-Franco M, Laber B, Huber R, Clausen T.

Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis.

J. Mol. Biol. 321 (2002) 601-12.

Escherichia coli [GN:eco]

3  [PMID:10225425]

Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS.

Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.

FEBS. Lett. 449 (1999) 45-8.

Escherichia coli [GN:eco]

4  [PMID:11286891]

Franco MG, Laber B, Huber R, Clausen T.

Structural basis for the function of pyridoxine 5'-phosphate synthase.

Structure. 9 (2001) 245-53.

Escherichia coli [GN:eco]