KEGG   ENZYME: 2.7.1.105Help
Entry
EC 2.7.1.105                Enzyme                                 
Name 6-phosphofructo-2-kinase;
phosphofructokinase 2;
6-phosphofructose 2-kinase;
6-phosphofructo-2-kinase (phosphorylating);
fructose 6-phosphate 2-kinase;
ATP:D-fructose-6-phosphate 2-phosphotransferase
Class Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname ATP:beta-D-fructose-6-phosphate 2-phosphotransferase
Reaction(IUBMB) ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose
2,6-bisphosphate [RN:R02732]
Reaction(KEGG) R02732
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Substrate ATP [CPD:C00002];
beta-D-fructose 6-phosphate [CPD:C05345]
Product ADP [CPD:C00008];
beta-D-fructose 2,6-bisphosphate [CPD:C00665]
Comment Not identical with EC 2.7.1.11 6-phosphofructokinase. The enzyme
co-purifies with EC 3.1.3.46 fructose-2,6-bisphosphate
2-phosphatase.
Pathway PATH: ec00051  Fructose and mannose metabolism
Orthology KO: K00900  6-phosphofructo-2-kinase
Genes HSA: 5207(PFKFB1) 5208(PFKFB2) 5209(PFKFB3) 5210(PFKFB4)
PTR: 738397(PFKFB3)
MCC: 709854 713062(PFKFB3)
MMU: 170768(Pfkfb3) 18639(Pfkfb1) 18640(Pfkfb2) 270198(Pfkfb4)
RNO: 117276(Pfkfb3) 24638(Pfkfb1) 24640(Pfkfb2) 54283(Pfkfb4)
CFA: 480011(PFKFB2) 484777(PFKFB4) 487139(PFKFB3) 491903(PFKFB1)
BTA: 282304(PFKFB1) 287019(PFKFB2) 407183(PFKFB3) 534928(PFKFB4)
SSC: 100158056 100233197(PFKFB1)
ECB: 100051146 100053840(PFKFB4) 100062514(PFKFB1) 100070251
MDO: 100010280 100014887 100020159 100023544
OAA: 100078789 100085808
GGA: 415906(PFKFB4) 418247(PFKFB3) 419850(PFKFB2)
TGU: 100220196 100227828 100232575
XLA: 432000 495408
XTR: 100170160(pfkfb2) 407880(TGas144d10.1)
DRE: 386663(pfkfb4l) 393983(pfkfb2) 554477(pfkfb3) 555486
     556190(pfkfb4) 564852
BFO: BRAFLDRAFT_277775
SPU: 579456 759612
DME: Dmel_CG3400(Pfrx)
DPO: Dpse_GA17426
DAN: Dana_GF20194
DER: Dere_GG19228
DSE: Dsec_GM22962
DYA: Dyak_GE15846
DGR: Dgri_GH17653
DMO: Dmoj_GI16091
AGA: AgaP_AGAP012010
AAG: AaeL_AAEL013132
CQU: CpipJ_CPIJ004664
AME: 409574
NVI: 100121543
TCA: 657985
API: 100162819
ISC: IscW_ISCW008488
CEL: K02B2.1(6-phosphofructo-2-kinase)
     Y110A7A.6(phosphofructokinase)
CBR: CBG09461 CBG10830
SMM: Smp_015710
NVE: NEMVE_v1g234745
HMG: 100203886
TAD: TRIADDRAFT_24566 TRIADDRAFT_37504
ATH: AT1G07110(F2KP)
POP: POPTR_815458 POPTR_821351
RCU: RCOM_1668120
VVI: 100244966(GSVIVT00024062001)
OSA: 4337906(Os05g0164100)
SBI: SORBI_09g004780(SORBIDRAFT_09g004780)
ZMA: 541911
PPP: PHYPADRAFT_146321 PHYPADRAFT_194396 PHYPADRAFT_61651
CRE: CHLREDRAFT_121054
OLU: OSTLU_40330
CME: CMN085C
SCE: YIL107C(PFK26) YJL155C(FBP26) YOL136C(PFK27)
AGO: AGOS_ADL183C AGOS_ADL237C AGOS_AEL106W
KLA: KLLA0B07513g KLLA0E07095g
LTH: KLTH0F05126g
DHA: DEHA0A11847g DEHA0B15741g DEHA0D03828g
PIC: PICST_57978(FRK26.2) PICST_66347(PFK26) PICST_68318(FBP26)
     PICST_85029(FRK26.1)
PPA: PAS_chr2-1_0110
VPO: Kpol_2001p19
LEL: LELG_03110
ZRO: ZYRO0G18216g
CTP: CTRG_03101
CDU: CD36_34140
CGR: CAGL0C01397g CAGL0E01529g CAGL0G01100g CAGL0I06094g
YLI: YALI0D21010g YALI0E17633g YALI0F27885g
SPO: SPAC222.13c SPAPB17E12.14c
NCR: NCU01728 NCU09347
PAN: PODANSg501
MGR: MGG_08582
FGR: FG04343.1
ANI: AN5144.2 AN6720.2
AFM: AFUA_1G07220 AFUA_7G05800
AOR: AO090005000444 AO090012000976
ANG: An07g02100
AFV: AFLA_076770
PCS: Pc20g01550
NFI: NFIA_027040
CIM: CIMG_05445
URE: UREG_06273
SSL: SS1G_10745
BFU: BC1G_15078
CNE: CNI03630
CNB: CNBH3460
LBC: LACBIDRAFT_254988
MPR: MPER_06685
UMA: UM02633.1
MGL: MGL_3954
MBR: MONBRDRAFT_27797
DDI: DDBDRAFT_0217769
PTM: GSPATT00007537001 GSPATT00020537001 GSPATT00032010001
TBR: Tb927.3.2710 Tb927.7.1610 Tb927.8.1020
TCR: 508153.950 508181.20
LMA: LmjF26.0310 LmjF36.0150
LIF: LinJ26.0300
LBZ: LbrM26_V2.0340
PTI: PHATRDRAFT_17495(PF2K1)
TPS: THAPSDRAFT_14563(PF2K1)
DVU: DVU3147
DVL: Dvul_0238
DVM: DvMF_1696
DDE: Dde_0511
DDS: Ddes_0350
DMA: DMR_34760(pfkfb)
LIP: LI0094(pfk)
DRT: Dret_0204
SCL: sce0036(fbp1)
Taxonomy
Structures PDB: 1BIF  1K6M  2AXN  2BIF  2DWO  2DWP  2I1V  3BIF  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:6458291]
Van Schaftingen E, Hers HG.
Phosphofructokinase 2: the enzyme that forms fructose
2,6-bisphosphate from fructose 6-phosphate and ATP.
Biochem. Biophys. Res. Commun. 101 (1981) 1078-84.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 2.7.1.105
IUBMB Enzyme Nomenclature: 2.7.1.105
ExPASy - ENZYME nomenclature database: 2.7.1.105
BRENDA, the Enzyme Database: 2.7.1.105
CAS: 78689-77-7
DBGET integrated database retrieval system