| Entry |
|
|---|
| Name |
inositol-trisphosphate 3-kinase;
1D-myo-inositol-trisphosphate 3-kinase;
Ins(1,4,5)P3 3-kinase |
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
|---|
| Sysname |
ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase |
|---|
| Reaction(IUBMB) |
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol
1,3,4,5-tetrakisphosphate [RN:R03433] |
|---|
| Reaction(KEGG) |
R03433
 |
|---|
| Substrate |
ATP [CPD:C00002];
1D-myo-inositol 1,4,5-trisphosphate [CPD:C01245] |
|---|
| Product |
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272] |
|---|
| Effector |
Calcium [CPD:C00076] |
|---|
| Comment |
Activated by Ca2+. Three isoforms have been shown to exist [3]. |
|---|
| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec01100 Metabolic pathways
PATH: ec04070 Phosphatidylinositol signaling system |
|---|
| Orthology |
KO: K00911 1D-myo-inositol-triphosphate 3-kinase |
|---|
| Genes |
HSA: 3706(ITPKA) 3707(ITPKB)
PTR: 453349(ITPKA) 457789(ITPKB)
MCC: 698185 710541(ITPKA)
MMU: 228550(Itpka) 320404(Itpkb)
RNO: 54260(Itpkb) 81677(Itpka)
CFA: 487507(ITPKA) 490383(ITPKB)
BTA: 540877(ITPKB) 615813(ITPKA)
ECB: 100058602 100147269
MDO: 100026399 100027749
OAA: 100082376
GGA: 395694(ITPKA) 416743(ITPKB)
TGU: 100219110 100224788
DRE: 563019 564528
BFO: BRAFLDRAFT_269201
CIN: 100182922
SPU: 590949
DME: Dmel_CG18854 Dmel_CG34359(IP3K2) Dmel_CG4026(IP3K1)
DPO: Dpse_GA14058 Dpse_GA17884
DAN: Dana_GF19401 Dana_GF22812
DER: Dere_GG10056 Dere_GG17771
DPE: Dper_GL18935 Dper_GL26915
DSE: Dsec_GM11620 Dsec_GM17705
DSI: Dsim_GD17114 Dsim_GD23630
DYA: Dyak_GE17061 Dyak_GE18870
DGR: Dgri_GH12819 Dgri_GH13823
DMO: Dmoj_GI15923 Dmoj_GI20140
AGA: AgaP_AGAP002194
AAG: AaeL_AAEL010766 AaeL_AAEL013183
CQU: CpipJ_CPIJ012003
AME: 409943(Ip3k) 413817
NVI: 100120589
TCA: 657796 661862
API: 100164481 100165797
ISC: IscW_ISCW014946 IscW_ISCW015457
CBR: CBG10794
SMM: Smp_140840
NVE: NEMVE_v1g88290
HMG: 100214171
TAD: TRIADDRAFT_27232
MBR: MONBRDRAFT_24063 MONBRDRAFT_30714
 |
|---|
| Structures |
PDB: 1TZD 2A98 2AQX |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:3487541]
Hansen CA, Mah S, Williamson JR.
Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in
liver.
J. Biol. Chem. 261 (1986) 8100-3.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:3010126]
Irvine RF, Letcher AJ, Heslop JP, Berridge MJ.
The inositol tris/tetrakisphosphate pathway--demonstration of
Ins(1,4,5)P3 3-kinase activity in animal tissues.
Nature. 320 (1986) 631-4. |
|---|
Reference
Authors
Title
Journal
|
3 [PMID:11331907]
Irvine RF, Schell MJ.
Back in the water: the return of the inositol phosphates.
Nat. Rev. Mol. Cell. Biol. 2 (2001) 327-38. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.127
IUBMB Enzyme Nomenclature: 2.7.1.127
ExPASy - ENZYME nomenclature database: 2.7.1.127
BRENDA, the Enzyme Database: 2.7.1.127
CAS: 106283-10-7 |
|---|
