KEGG   ENZYME: 2.7.1.134Help
Entry
EC 2.7.1.134                Enzyme                                 
Name inositol-tetrakisphosphate 1-kinase;
1D-myo-inositol-tetrakisphosphate 1-kinase;
inositol-trisphosphate 6-kinase;
1D-myo-inositol-trisphosphate 6-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase;
inositol-trisphosphate 5-kinase;
1D-myo-inositol-trisphosphate 5-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase
Class Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase
Reaction(IUBMB) ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP +
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R03479]
Reaction(KEGG) R03479;
(other) R03428 R03429
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Substrate ATP [CPD:C00002];
1D-myo-inositol 3,4,5,6-tetrakisphosphate [CPD:C04520]
Product ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
Comment This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The
phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or
inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible
to the extent that the enzyme can act like an inositol polyphosphate
phosphatase in the presence of ADP. It can also catalyse an
isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the
presence of ADP.
Pathway PATH: ec00562  Inositol phosphate metabolism
PATH: ec01100  Metabolic pathways
PATH: ec04070  Phosphatidylinositol signaling system
Orthology KO: K00913  1D-myo-Inositol-trisphosphate 6-kinase
Genes HSA: 3705(ITPK1)
MCC: 698756
MMU: 217837(Itpk1)
CFA: 490591(ITPK1)
BTA: 518488(ITPK1)
SSC: 100152339(ITPK1)
ECB: 100063828
MDO: 100014342
OAA: 100079832
GGA: 423421(ITPK1)
TGU: 100222999
XLA: 379828(itpk1)
XTR: 549890(itpk1)
DRE: 100148744 406290(itpk1)
CIN: 100181853
SPU: 580408
AME: 551726
TCA: 660348
NVE: NEMVE_v1g170935
TAD: TRIADDRAFT_57121
ATH: AT4G08170
MBR: MONBRDRAFT_33295
DDI: DDB_0238430(ITPK1)
EHI: EHI_100310
TET: TTHERM_00530360
TVA: TVAG_463930
Taxonomy
Structures PDB: 2ODT  2Q7D  2QB5  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:2829850]
Stephens LR, Hawkins PT, Morris AJ, Downes PC.
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase.
Biochem. J. 249 (1988) 283-92.
Mus musculus [GN:mmu], Rattus norvegicus [GN:rno]
Reference
  Authors
  Title


  Journal
  Organism
 2  [PMID:3497156]
Balla T, Guillemette G, Baukal AJ, Catt KJ.
Metabolism of inositol 1,3,4-trisphosphate to a new
tetrakisphosphate isomer in angiotensin-stimulated adrenal
glomerulosa cells.
J. Biol. Chem. 262 (1987) 9952-5.
Bos taurus [GN:bta]
Reference
  Authors
  Title


  Journal
  Organism
 3  [PMID:2823793]
Shears SB, Parry JB, Tang EK, Irvine RF, Michell RH, Kirk CJ.
Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver,
including the synthesis of a novel isomer of myo-inositol
tetrakisphosphate.
Biochem. J. 246 (1987) 139-47.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title



  Journal
  Organism
 4  [PMID:2584198]
Shears SB.
The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in
liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase,
myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol
1,3,4,6-tetrakisphosphate 5-kinase.
J. Biol. Chem. 264 (1989) 19879-86.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
 5  [PMID:11042108]
Yang X, Shears SB.
Multitasking in signal transduction by a promiscuous human
Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.
Biochem. J. 351 Pt 3 (2000) 551-5.
Homo sapiens [GN:hsa]
Reference
  Authors

  Title

  Journal
  Organism
 6  [PMID:11909533]
Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S,
Vogel G, Riley AM, Potter BV, Shears SB.
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible
kinase/phosphatase.
Curr. Biol. 12 (2002) 477-82.
Homo sapiens [GN:hsa]
Other DBs ExplorEnz - The Enzyme Database: 2.7.1.134
IUBMB Enzyme Nomenclature: 2.7.1.134
ExPASy - ENZYME nomenclature database: 2.7.1.134
BRENDA, the Enzyme Database: 2.7.1.134
CAS: 187175-98-0
DBGET integrated database retrieval system