| Entry |
|
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| Name |
phosphatidylinositol 3-kinase;
1-phosphatidylinositol 3-kinase;
type III phosphoinositide 3-kinase;
Vps34p;
type I phosphatidylinositol kinase |
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
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| Sysname |
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase |
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| Reaction(IUBMB) |
ATP + 1-phosphatidyl-1D-myo-inositol = ADP +
1-phosphatidyl-1D-myo-inositol 3-phosphate [RN:R03362] |
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| Reaction(KEGG) |
R03362
 |
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| Substrate |
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol [CPD:C01194] |
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| Product |
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 3-phosphate [CPD:C04549] |
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| Comment |
One mammalian isoform is known. |
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| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec01100 Metabolic pathways
PATH: ec04070 Phosphatidylinositol signaling system |
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| Orthology |
KO: K00914 phosphatidylinositol 3-kinase |
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| Genes |
HSA: 5289(PIK3C3)
PTR: 455385(PIK3C3)
MCC: 693918(PIK3C3)
MMU: 225326(Pik3c3)
RNO: 65052(Pik3c3)
CFA: 490477(PIK3C3)
BTA: 534815(PIK3C3)
SSC: 503700(PIK3C3)
ECB: 100053039(PIK3C3)
MDO: 100011397
TGU: 100221298
XLA: 446671(pik3c3)
DRE: 548346(pik3c3)
BFO: BRAFLDRAFT_280369
CIN: 100182163
SPU: 591736
DME: Dmel_CG5373(Pi3K59F)
DPO: Dpse_GA18829
DAN: Dana_GF13065
DER: Dere_GG22867
DPE: Dper_GL16871
DSE: Dsec_GM16028
DSI: Dsim_GD11777
DYA: Dyak_GE14305
DGR: Dgri_GH21209
DMO: Dmoj_GI20497
AGA: AgaP_AGAP010273
AAG: AaeL_AAEL009826
CQU: CpipJ_CPIJ002386
AME: 725770
NVI: 100119508
TCA: 656409
API: 100166620
ISC: IscW_ISCW008679
CEL: B0025.1(vps-34)
CBR: CBG22101
BMY: Bm1_09860
SMM: Smp_128130
NVE: NEMVE_v1g1773 NEMVE_v1g91901
HMG: 100215627
TAD: TRIADDRAFT_22684
ATH: AT1G60490
POP: POPTR_806443
RCU: RCOM_0528000
VVI: 100263708(GSVIVT00002733001)
OSA: 4337982(Os05g0180600) 4345232(Os08g0307400)
PPP: PHYPADRAFT_182554
CRE: CHLREDRAFT_196943(VPS34)
OLU: OSTLU_34142
SCE: YLR240W(VPS34)
AGO: AGOS_AGL113C
KLA: KLLA0D18645g
LTH: KLTH0F08404g
DHA: DEHA0G14157g
PIC: PICST_42745(VPS34)
PPA: PAS_chr4_0478
VPO: Kpol_1043p51
LEL: LELG_00604
ZRO: ZYRO0C04356g
CAL: CaO19.13621(VPS34) CaO19.6243(VPS34)
CTP: CTRG_04216
CDU: CD36_06260
CGR: CAGL0G08360g
YLI: YALI0F09559g
SPO: SPAC458.05(pik3)
NCR: NCU00656
PAN: PODANSg4500
MGR: MGG_03069
FGR: FG08522.1
ANI: AN4709.2
AFM: AFUA_5G08670
AOR: AO090020000426
ANG: An07g04820
AFV: AFLA_099880
PCS: Pc21g00590
NFI: NFIA_078610
CIM: CIMG_06770
URE: UREG_03695
SSL: SS1G_11324
BFU: BC1G_08774
CNE: CNB03120
CNB: CNBB2580
LBC: LACBIDRAFT_249530
UMA: UM00453.1
MGL: MGL_1161
MBR: MONBRDRAFT_20335
DDI: DDB_0219939(pikE)
EHI: EHI_096560
EDI: EDI_092540
PFA: PFE0765w
PFD: PFDG_01210
PFH: PFHG_00215
PYO: PY00334
PCB: PC000310.03.0
PBE: PB001147.01.0
PKN: PKH_101740
PVX: PVX_080480
CPV: cgd6_1760
CHO: Chro.60213
TET: TTHERM_00203010 TTHERM_00649380
PTM: GSPATT00022039001
TBR: Tb11.01.6980 Tb927.1.1930 Tb927.8.6210
TCR: 506425.80 509989.10 511903.160
LMA: LmjF20.1120 LmjF24.2010 LmjF30.1850
LIF: LinJ20.1150 LinJ24.1390 LinJ30.2180
LBZ: LbrM17_V2.0840 LbrM24_V2.2090
TVA: TVAG_006610 TVAG_045170 TVAG_332500
PTI: PHATRDRAFT_30282
TPS: THAPSDRAFT_36937
 |
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| Structures |
PDB: 1E7U 1E7V 1E8W 1E8X 1E8Y 1E8Z 1E90 1HE8 1PIC 1PKS
1PKT 1W1N 2CHW 2CHX 2CHZ 2IWL 2PNA 2PNB 3IHY |
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Reference
Authors
Title
Journal
|
1 [PMID:2833705]
Whitman M, Downes CP, Keeler M, Keller T, Cantley L.
Type I phosphatidylinositol kinase makes a novel inositol
phospholipid, phosphatidylinositol-3-phosphate.
Nature. 332 (1988) 644-6. |
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Reference
Authors
Title
Journal
Organism
|
2 [PMID:11395417]
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll
PC, Woscholski R, Parker PJ, Waterfield MD.
Synthesis and function of 3-phosphorylated inositol lipids.
Annu. Rev. Biochem. 70 (2001) 535-602.
Drosophila melanogaster [GN:dme], Caenorhabditis elegans [GN:cel],
Dictyostelium discoideum [GN:ddi], mammalian |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.137
IUBMB Enzyme Nomenclature: 2.7.1.137
ExPASy - ENZYME nomenclature database: 2.7.1.137
BRENDA, the Enzyme Database: 2.7.1.137
CAS: 115926-52-8 |
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