KEGG   ENZYME: 2.7.1.147Help
Entry
EC 2.7.1.147                Enzyme                                 

Name
ADP-specific glucokinase;
ADP-dependent glucokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ADP:D-glucose 6-phosphotransferase
Reaction(IUBMB)
ADP + D-glucose = AMP + D-glucose 6-phosphate [RN:R05804]
Reaction(KEGG)
Substrate
ADP [CPD:C00008];
D-glucose [CPD:C00031]
Product
AMP [CPD:C00020];
D-glucose 6-phosphate [CPD:C00092]
Comment
Requires Mg2+. The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.
History
EC 2.7.1.147 created 2001
Pathway
Glycolysis / Gluconeogenesis
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Orthology
K00918  
ADP-dependent phosphofructokinase/glucokinase
K08074  
ADP-dependent glucokinase
Genes
HSA: 
83440(ADPGK)
PTR: 
748791(ADPGK)
PPS: 
100988588(ADPGK)
GGO: 
101140731(ADPGK)
PON: 
100173850(ADPGK)
NLE: 
100596634(ADPGK)
MCC: 
699257(ADPGK)
MCF: 
CJC: 
100385481(ADPGK)
MMU: 
72141(Adpgk)
RNO: 
315722(Adpgk)
CGE: 
100754978(Adpgk)
NGI: 
103736851(Adpgk)
HGL: 
101717458(Adpgk)
OCU: 
100347024(ADPGK)
TUP: 
102498911(ADPGK)
CFA: 
478360(ADPGK)
AML: 
100473629(ADPGK)
UMR: 
103679135(ADPGK)
FCA: 
101088581(ADPGK)
PTG: 
102961110(ADPGK)
BTA: 
518158(ADPGK)
BOM: 
102286604(ADPGK)
PHD: 
102330752(ADPGK)
CHX: 
102181503(ADPGK)
OAS: 
101116836(ADPGK)
SSC: 
100623786(ADPGK)
CFR: 
102523920(ADPGK)
BACU: 
103021058(ADPGK)
LVE: 
103082058(ADPGK)
ECB: 
100052166(ADPGK)
MYB: 
102260287(ADPGK)
MYD: 
102775076(ADPGK)
PALE: 
102897483(ADPGK)
MDO: 
100016323(ADPGK)
SHR: 
100921460(ADPGK)
OAA: 
100077123(ADPGK)
GGA: 
415317(ADPGK)
MGP: 
APLA: 
101797470(ADPGK)
TGU: 
100230242(ADPGK)
FAB: 
101814955(ADPGK)
PHI: 
102108989(ADPGK)
FPG: 
101912436(ADPGK)
FCH: 
102052366(ADPGK)
CLV: 
102093047(ADPGK)
ASN: 
102369271(ADPGK)
AMJ: 
102576175(ADPGK)
PSS: 
102444452(ADPGK)
CMY: 
102945709(ADPGK)
ACS: 
100567625(adpgk)
PBI: 
103059020(ADPGK)
XTR: 
DRE: 
557919(adpgk) 566398(adpgk2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
NVI: 
BMOR: 
ISC: 
CEL: 
CELE_C50D2.7(C50D2.7)
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
NVE: 
HMG: 
TAD: 
AQU: 
DDI: 
DPP: 
DFA: 
DFA_06097(cmfA)
ACAN: 
PTM: 
PIF: 
RLT: 
TCO: 
CSH: 
SKE: 
SSM: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP1296(pfkC)
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA3562(glkA) MA3563(pfk)
MBA: 
MMA: 
MBU: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MCON_0234(pfkC)
MBN: 
NMG: 
NGE: 
HRU: 
PHO: 
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TGAM_0818(glkA) TGAM_1465(pfkC)
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
PPAC: 
 » show all
Taxonomy
Reference
1  [PMID:8530474]
  Authors
Kengen SW, Tuininga JE, de Bok FA, Stams AJ, de Vos WM.
  Title
Purification and characterization of a novel ADP-dependent glucokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J. Biol. Chem. 270 (1995) 30453-7.
  Sequence
[pfu:PF0312]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
173585-07-4

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