KEGG   ENZYME: 2.7.1.149Help
Entry
EC 2.7.1.149                Enzyme                                 
Name 1-phosphatidylinositol-5-phosphate 4-kinase;
type II PIP kinase
Class Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase
Reaction(IUBMB) ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP +
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [RN:R05803]
Reaction(KEGG) R05803
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Substrate ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 5-phosphate [CPD:C11557]
Product ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637]
Pathway PATH: ec00562  Inositol phosphate metabolism
PATH: ec04070  Phosphatidylinositol signaling system
Orthology KO: K00920  1-phosphatidylinositol-5-phosphate 4-kinase
Genes HSA: 5305(PIP4K2A) 79837(PIP4K2C)
PTR: 467044(PIP4K2C) 742458(PIP4K2A)
MCC: 710724(PIP4K2A) 715120
MMU: 117150(Pip4k2c) 18718(Pip4k2a)
RNO: 116723(Pip4k2a) 140607(Pip4k2c)
CFA: 474417(PIP4K2C) 608414(PIP4K2A) 609860
BTA: 533289(PIP4K2A) 540005(PIP4K2C)
ECB: 100053518 100066733
MDO: 100019731
OAA: 100079689
GGA: 420504(PIP4K2A)
TGU: 100219125
XLA: 496028(pip5k2c)
XTR: 100170468 448167(pip5k2c)
DRE: 373124(pip5k2) 560360
CIN: 100175764
TCA: 660048
ISC: IscW_ISCW009432
CEL: Y48G9A.8(ppk-2)
CBR: CBG15109
BMY: Bm1_57205
HMG: 100204551
TAD: TRIADDRAFT_22804
MBR: MONBRDRAFT_25091
TPV: TP02_0200
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:9367159]
Rameh LE, Tolias KF, Duckworth BC, Cantley LC.
A new pathway for synthesis of
phosphatidylinositol-4,5-bisphosphate.
Nature. 390 (1997) 192-6.
Homo sapiens [GN:hsa]
Other DBs ExplorEnz - The Enzyme Database: 2.7.1.149
IUBMB Enzyme Nomenclature: 2.7.1.149
ExPASy - ENZYME nomenclature database: 2.7.1.149
BRENDA, the Enzyme Database: 2.7.1.149
CAS: 247907-17-1
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