| Entry |
|
|---|
| Name |
inositol-polyphosphate multikinase;
IpK2;
IP3/IP4 6-/3-kinase;
IP3/IP4 dual-specificity 6-/3-kinase;
IpmK;
ArgRIII;
AtIpk2alpha;
AtIpk2beta;
inositol polyphosphate 6-/3-/5-kinase |
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
|---|
| Sysname |
ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase |
|---|
| Reaction(IUBMB) |
(1) (1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP +
1D-myo-inositol 1,4,5,6-tetrakisphosphate [RN:R05800];
(2) (1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP +
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R05801] |
|---|
| Reaction(KEGG) |
R05800 R05801
 |
|---|
| Substrate |
ATP [CPD:C00002];
1D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
1D-myo-inositol 1,4,5,6-tetrakisphosphate [CPD:C11555] |
|---|
| Product |
ADP [CPD:C00008];
1D-myo-inositol 1,4,5,6-tetrakisphosphate [CPD:C11555];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284] |
|---|
| Comment |
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4,
Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to
Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis
thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5
at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and
inositol hexakisphosphate (InsP6), respectively [3]. Yeast produce
InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC
2.7.1.158, inositol-pentakisphosphate 2-kinase [4]. |
|---|
| Pathway |
PATH: ec00562 Inositol phosphate metabolism |
|---|
| Orthology |
KO: K00328 inositol-polyphosphate multikinase |
|---|
| Genes |
HSA: 253430(IPMK)
PTR: 450471(IPMK)
MCC: 703630(IPMK)
MMU: 69718(Ipmk)
RNO: 171458(Ipmk)
CFA: 488988(IPMK)
BTA: 615135(IPMK)
SSC: 100156180
ECB: 100072153(IPMK)
MDO: 100024450
OAA: 100076322
GGA: 769967(IPMK)
TGU: 100225175
XLA: 447535
DRE: 790916
NVE: NEMVE_v1g219446
SCE: YDR173C(ARG82)
AGO: AGOS_AGL144C
KLA: KLLA0D17402g
DHA: DEHA0B09768g
UMA: UM04962.1
TVA: TVAG_403580
 |
|---|
| Structures |
PDB: 2IEW 2IF8 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:10574768]
Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH.
Synthesis of diphosphoinositol pentakisphosphate by a newly
identified family of higher inositol polyphosphate kinases.
Curr. Biol. 9 (1999) 1323-6.
Saccharomyces cerevisiae [GN:sce] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:10720331]
Odom AR, Stahlberg A, Wente SR, York JD.
A role for nuclear inositol 1,4,5-trisphosphate kinase in
transcriptional control.
Science. 287 (2000) 2026-9.
Saccharomyces cerevisiae [GN:sce] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:12226109]
Stevenson-Paulik J, Odom AR, York JD.
Molecular and biochemical characterization of two plant inositol
polyphosphate 6-/3-/5-kinases.
J. Biol. Chem. 277 (2002) 42711-8.
Arabidopsis thaliana [GN:ath] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:15531582]
Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW.
The pathway for the production of inositol hexakisphosphate in human
cells.
J. Biol. Chem. 280 (2005) 1911-20.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.151
IUBMB Enzyme Nomenclature: 2.7.1.151
ExPASy - ENZYME nomenclature database: 2.7.1.151
BRENDA, the Enzyme Database: 2.7.1.151
CAS: 9077-69-4 |
|---|
|
