KEGG   ENZYME: 2.7.1.153Help
Entry
EC 2.7.1.153                Enzyme                                 

Name phosphatidylinositol-4,5-bisphosphate 3-kinase;
type I phosphoinositide 3-kinase
Class Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate
3-phosphotransferase
Reaction(IUBMB) ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP +
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [RN:R04545]
Reaction(KEGG) R04545
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Substrate ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637]
Product ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [CPD:C05981]
Comment This enzyme also catalyses the phosphorylation of PtdIns4P to
PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms
are known to exist.
Pathway PATH: ec00562  Inositol phosphate metabolism
PATH: ec04070  Phosphatidylinositol signaling system
Orthology KO: K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase
Genes HSA: 5290(PIK3CA) 5291(PIK3CB) 5293(PIK3CD) 5294(PIK3CG)
PTR: 457922(PIK3CD) 460858(PIK3CA) 463649(PIK3CG)
MCC: 698857(PIK3CG) 709959 716098(PIK3CB)
MMU: 18706(Pik3ca) 18707(Pik3cd) 30955(Pik3cg) 74769(Pik3cb)
RNO: 170911(Pik3ca) 298947(Pik3cg) 366508(Pik3cd) 685590 685605
     685626 85243(Pik3cb)
CFA: 477085(PIK3CB) 483266(PIK3CG) 488084(PIK3CA) 489644(PIK3CD)
BTA: 282306(PIK3CA) 504531(PIK3CD) 517948(PIK3CB) 530001(PIK3CG)
SSC: 396979(PIK3CG)
ECB: 100050532 100051623(PIK3CD) 100051753 100058141
MDO: 100009879 100010412
OAA: 100073788 100086270
GGA: 417706(PIK3CG) 419444(PIK3CD) 424826(PIK3CB) 424971(PIK3CA)
TGU: 100229232
XTR: 100144924 100158519 780390(pik3cb)
DRE: 100002263 394174(pik3cd) 406598 561737 564261
BFO: BRAFLDRAFT_228095 BRAFLDRAFT_94886
CIN: 100180112 100180924 100183611
SPU: 588097 754280 758343
DME: Dmel_CG4141(Pi3K92E)
DPO: Dpse_GA17984
DAN: Dana_GF18327
DER: Dere_GG15290
DPE: Dper_GL27142
DSE: Dsec_GM23175
DSI: Dsim_GD20048
DYA: Dyak_GE25053
DGR: Dgri_GH16124
DMO: Dmoj_GI22170
AGA: AgaP_AGAP000018
AAG: AaeL_AAEL002903
CQU: CpipJ_CPIJ005543
AME: 551500
NVI: 100115810
TCA: 657286
API: 100160001
ISC: IscW_ISCW010469 IscW_ISCW014229
CEL: B0334.8(age-1)
CBR: CBG02868
BMY: Bm1_55680
SMM: Smp_164960
NVE: NEMVE_v1g242402
HMG: 100210375
TAD: TRIADDRAFT_26293
MBR: MONBRDRAFT_18656(PI3K-CA_alpha)
DDI: DDB_0185203(pikC) DDB_0214949(pikA)
EHI: EHI_006130 EHI_095130
EDI: EDI_013060 EDI_198920
TCR: 508859.90 510167.10
LIF: LinJ14.0020
TVA: TVAG_284350
Taxonomy
Structures PDB: 2A4Z  2A5U  2CHW  2CHX  2CHZ  2ENQ  2RD0  2V1Y  2V4L  2WXE  
     2WXF  2WXG  2WXH  2WXI  2WXJ  2WXK  2WXL  2WXM  2WXN  2WXO  
     2WXP  2WXQ  2WXR  3CSF  3CST  3DBS  3DPD  3ENE  3HHM  3HIZ  
     3IBE  
Reference
  Authors

  Title
  Journal
  Organism

1  [PMID:11395417]
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll
PC, Woscholski R, Parker PJ, Waterfield MD.
Synthesis and function of 3-phosphorylated inositol lipids.
Annu. Rev. Biochem. 70 (2001) 535-602.
Drosophila melanogaster [GN:dme], Caenorhabditis elegans [GN:cel],
Dictyostelium discoideum [GN:ddi], mammalian
Other DBs ExplorEnz - The Enzyme Database: 2.7.1.153
IUBMB Enzyme Nomenclature: 2.7.1.153
ExPASy - ENZYME nomenclature database: 2.7.1.153
BRENDA, the Enzyme Database: 2.7.1.153
CAS: 103843-30-7

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