| Entry |
|
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| Name |
phosphatidylinositol-4,5-bisphosphate 3-kinase;
type I phosphoinositide 3-kinase |
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
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| Sysname |
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate
3-phosphotransferase |
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| Reaction(IUBMB) |
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP +
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [RN:R04545] |
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| Reaction(KEGG) |
R04545
 |
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| Substrate |
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637] |
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| Product |
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [CPD:C05981] |
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| Comment |
This enzyme also catalyses the phosphorylation of PtdIns4P to
PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms
are known to exist. |
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| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec04070 Phosphatidylinositol signaling system |
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| Orthology |
KO: K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase |
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| Genes |
HSA: 5290(PIK3CA) 5291(PIK3CB) 5293(PIK3CD) 5294(PIK3CG)
PTR: 457922(PIK3CD) 460858(PIK3CA) 463649(PIK3CG)
MCC: 698857(PIK3CG) 709959 716098(PIK3CB)
MMU: 18706(Pik3ca) 18707(Pik3cd) 30955(Pik3cg) 74769(Pik3cb)
RNO: 170911(Pik3ca) 298947(Pik3cg) 366508(Pik3cd) 685590 685605
685626 85243(Pik3cb)
CFA: 477085(PIK3CB) 483266(PIK3CG) 488084(PIK3CA) 489644(PIK3CD)
BTA: 282306(PIK3CA) 504531(PIK3CD) 517948(PIK3CB) 530001(PIK3CG)
SSC: 396979(PIK3CG)
ECB: 100050532 100051623(PIK3CD) 100051753 100058141
MDO: 100009879 100010412
OAA: 100073788 100086270
GGA: 417706(PIK3CG) 419444(PIK3CD) 424826(PIK3CB) 424971(PIK3CA)
TGU: 100229232
XTR: 100144924 100158519 780390(pik3cb)
DRE: 100002263 394174(pik3cd) 406598 561737 564261
BFO: BRAFLDRAFT_228095 BRAFLDRAFT_94886
CIN: 100180112 100180924 100183611
SPU: 588097 754280 758343
DME: Dmel_CG4141(Pi3K92E)
DPO: Dpse_GA17984
DAN: Dana_GF18327
DER: Dere_GG15290
DPE: Dper_GL27142
DSE: Dsec_GM23175
DSI: Dsim_GD20048
DYA: Dyak_GE25053
DGR: Dgri_GH16124
DMO: Dmoj_GI22170
AGA: AgaP_AGAP000018
AAG: AaeL_AAEL002903
CQU: CpipJ_CPIJ005543
AME: 551500
NVI: 100115810
TCA: 657286
API: 100160001
ISC: IscW_ISCW010469 IscW_ISCW014229
CEL: B0334.8(age-1)
CBR: CBG02868
BMY: Bm1_55680
SMM: Smp_164960
NVE: NEMVE_v1g242402
HMG: 100210375
TAD: TRIADDRAFT_26293
MBR: MONBRDRAFT_18656(PI3K-CA_alpha)
DDI: DDB_0185203(pikC) DDB_0214949(pikA)
EHI: EHI_006130 EHI_095130
EDI: EDI_013060 EDI_198920
TCR: 508859.90 510167.10
LIF: LinJ14.0020
TVA: TVAG_284350
 |
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| Structures |
PDB: 2A4Z 2A5U 2CHW 2CHX 2CHZ 2ENQ 2RD0 2V1Y 2V4L 2WXE
2WXF 2WXG 2WXH 2WXI 2WXJ 2WXK 2WXL 2WXM 2WXN 2WXO
2WXP 2WXQ 2WXR 3CSF 3CST 3DBS 3DPD 3ENE 3HHM 3HIZ
3IBE |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:11395417]
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll
PC, Woscholski R, Parker PJ, Waterfield MD.
Synthesis and function of 3-phosphorylated inositol lipids.
Annu. Rev. Biochem. 70 (2001) 535-602.
Drosophila melanogaster [GN:dme], Caenorhabditis elegans [GN:cel],
Dictyostelium discoideum [GN:ddi], mammalian |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.153
IUBMB Enzyme Nomenclature: 2.7.1.153
ExPASy - ENZYME nomenclature database: 2.7.1.153
BRENDA, the Enzyme Database: 2.7.1.153
CAS: 103843-30-7 |
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