KEGG   ENZYME: 2.7.1.153Help
Entry
EC 2.7.1.153                Enzyme                                 
Name
phosphatidylinositol-4,5-bisphosphate 3-kinase;
type I phosphoinositide 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
Reaction(IUBMB)
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [RN:R04545]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637]
Product
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [CPD:C05981]
Comment
This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist.
Pathway
Inositol phosphate metabolism
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase
Genes
HSA: 
5290(PIK3CA) 5291(PIK3CB) 5293(PIK3CD) 5294(PIK3CG)
PTR: 
457922(PIK3CD) 460858(PIK3CA) 463649(PIK3CG) 471079(PIK3CB)
PPS: 
100988420(PIK3CG) 100989732(PIK3CD) 100990108(PIK3CB) 100990828(PIK3CA)
GGO: 
101143811(PIK3CA) 101146434(PIK3CD) 101152123(PIK3CB) 101153738(PIK3CG)
PON: 
100432846(PIK3CB) 100453085(PIK3CG) 100453779(PIK3CA)
MCC: 
698857(PIK3CG) 709959(PIK3CA) 716098(PIK3CB)
MMU: 
18706(Pik3ca) 18707(Pik3cd) 30955(Pik3cg) 74769(Pik3cb)
RNO: 
170911(Pik3ca) 298947(Pik3cg) 366508(Pik3cd) 85243(Pik3cb)
CFA: 
477085(PIK3CB) 483266(PIK3CG) 488084(PIK3CA) 489644(PIK3CD)
AML: 
FCA: 
101091892(PIK3CB) 101094274(PIK3CD) 101096215(PIK3CG) 101097413(PIK3CA)
BTA: 
282306(PIK3CA) 504531(PIK3CD) 517948(PIK3CB) 530001(PIK3CG)
SSC: 
100518131(PIK3CD) 100622663(PIK3CB) 396979(PIK3CG)
ECB: 
100051623(PIK3CD) 100051753(PIK3CB) 100058141
MDO: 
100009879 100010412 100017332
SHR: 
100925455(PIK3CG) 100929811 100932099(PIK3CA)
OAA: 
100073788 100078046 100086270(PIK3CB)
GGA: 
417706(PIK3CG) 419444(PIK3CD) 424826(PIK3CB) 424971(PIK3CA)
MGP: 
100543492 100546867 100546933
TGU: 
100224188(PIK3CD) 100229232(PIK3CG) 100229768(PIK3CA)
ACS: 
100561444 100562345 100567254(pik3cb) 100568252
XTR: 
100144924(pik3ca) 100158519(pik3cg) 780390(pik3cb)
DRE: 
100002263(pik3cb) 394174(pik3cd) 406598(pik3cg) 561737 564261(pik3cg)
TRU: 
101066166 101067191 101068840 101071229 101075343 101076867
OLA: 
101161626 101161887 101165660 101168152 101173828
BFO: 
BRAFLDRAFT_228095 BRAFLDRAFT_94886
CIN: 
100180112(pik3cg) 100183611
SPU: 
100887922 588097 754280
DME: 
Dmel_CG4141(Pi3K92E)
DPO: 
Dpse_GA17984
DAN: 
Dana_GF18327
DER: 
Dere_GG15290
DPE: 
Dper_GL27142
DSE: 
Dsec_GM23175
DSI: 
Dsim_GD20048
DWI: 
Dwil_GK22711
DYA: 
Dyak_GE25053
DGR: 
Dgri_GH16124
DMO: 
Dmoj_GI22170
DVI: 
Dvir_GJ24290
AGA: 
AgaP_AGAP000018
AAG: 
AaeL_AAEL002903
CQU: 
CpipJ_CPIJ005543
AME: 
551500
NVI: 
100115810(Pik3cb)
TCA: 
657286
API: 
100160001
PHU: 
Phum_PHUM169940
ISC: 
IscW_ISCW010469 IscW_ISCW014229
CBR: 
CBG02868(Cbr-age-1)
BMY: 
Bm1_55680
SMM: 
Smp_164960
NVE: 
NEMVE_v1g242402
HMG: 
100210375
TAD: 
TRIADDRAFT_26293
AQU: 
100638758 100640192
SMO: 
SELMODRAFT_109582
MBR: 
MONBRDRAFT_18656(PI3K-CA_alpha)
NGR: 
NAEGRDRAFT_270 NAEGRDRAFT_29590 NAEGRDRAFT_48457
DDI: 
DDB_G0275011(pikC) DDB_G0278727(pikA)
DPP: 
DICPUDRAFT_149892 DICPUDRAFT_58194
EHI: 
EHI_006130(83.t00026) EHI_095130(269.t00003)
EDI: 
EDI_013060 EDI_198920
PTM: 
GSPATT00039649001
TCR: 
508859.90 510167.10
LIF: 
LINJ_14_0020
LDO: 
LDBPK_140020
LMI: 
LMXM_14_0020
GLA: 
GL50803_14855
TVA: 
TVAG_284350
 » show all
Taxonomy
Reference
1  [PMID:11395417]
  Authors
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD.
  Title
Synthesis and function of 3-phosphorylated inositol lipids.
  Journal
Annu. Rev. Biochem. 70 (2001) 535-602.
  Organism
Drosophila melanogaster [GN:dme], Caenorhabditis elegans [GN:cel], Dictyostelium discoideum [GN:ddi], mammalian
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
103843-30-7
DBGET integrated database retrieval system