| Entry |
|
|---|
| Name |
ketohexokinase;
ketohexokinase (phosphorylating) |
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
|---|
| Sysname |
ATP:D-fructose 1-phosphotransferase |
|---|
| Reaction(IUBMB) |
ATP + D-fructose = ADP + D-fructose 1-phosphate [RN:R00866] |
|---|
| Reaction(KEGG) |
R00866;
(other) R03819
 |
|---|
| Substrate |
ATP [CPD:C00002];
D-fructose [CPD:C00095] |
|---|
| Product |
ADP [CPD:C00008];
D-fructose 1-phosphate [CPD:C01094] |
|---|
| Comment |
D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other
ketoses and their analogues can also act as substrates [4]. |
|---|
| Pathway |
PATH: ec00051 Fructose and mannose metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00846 ketohexokinase |
|---|
| Genes |
HSA: 3795(KHK)
MCC: 698328(KHK)
MMU: 16548(Khk)
RNO: 25659(Khk)
BTA: 614868(KHK)
ECB: 100055449
MDO: 100025922
OAA: 100078974
XLA: 447317
DRE: 436909(khk)
SPU: 588197
DME: Dmel_CG12289 Dmel_CG7328 Dmel_CG7335 Dmel_CG7551
DPO: Dpse_GA20264
NVE: NEMVE_v1g199886
NOC: Noc_2848
HHA: Hhal_0921
NPH: NP3184A(suk)
 |
|---|
| Structures |
PDB: 2HLZ 2HQQ 2HW1 3B3L |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14858418]
CORI GT, OCHOA S, SLEIN MW, CORI CF.
The metabolism of fructose in liver; isolation of
fructose-I-phosphate and inorganic pyrophosphate.
Biochim. Biophys. Acta. 7 (1951) 304-17.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13208667]
HERS HG.
[Liver fructokinase.]
Biochim. Biophys. Acta. 8 (1952) 416-23.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13449068]
PARKS RE Jr, BEN-GERSHOM E, LARDY HA.
Liver fructokinase.
J. Biol. Chem. 227 (1957) 231-42.
Rattus norvegicus [GN:rno], Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:193556]
Raushel FM, Cleland WW.
Bovine liver fructokinase: purification and kinetic properties.
Biochemistry. 16 (1977) 2169-75.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.3
IUBMB Enzyme Nomenclature: 2.7.1.3
ExPASy - ENZYME nomenclature database: 2.7.1.3
BRENDA, the Enzyme Database: 2.7.1.3
CAS: 9030-50-6 |
|---|
