KEGG   ENZYME: 2.7.1.3Help
Entry
EC 2.7.1.3                  Enzyme                                 
Name
ketohexokinase;
ketohexokinase (phosphorylating)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:D-fructose 1-phosphotransferase
Reaction(IUBMB)
ATP + D-fructose = ADP + D-fructose 1-phosphate [RN:R00866]
Reaction(KEGG)
R00866;
(other) R03819
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Substrate
ATP [CPD:C00002];
D-fructose [CPD:C00095]
Product
ADP [CPD:C00008];
D-fructose 1-phosphate [CPD:C01094]
Comment
D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other ketoses and their analogues can also act as substrates [4].
Pathway
Fructose and mannose metabolism
Metabolic pathways
Orthology
K00846  
ketohexokinase
Genes
HSA: 
3795(KHK)
PTR: 
740614(KHK)
PPS: 
GGO: 
PON: 
MCC: 
698328(KHK)
MMU: 
16548(Khk)
RNO: 
25659(Khk)
CFA: 
AML: 
FCA: 
101080375(KHK)
BTA: 
614868(KHK)
SSC: 
100523241
ECB: 
100055449
MDO: 
100025922
OAA: 
100078974
ACS: 
100561006
XLA: 
447317(khk)
XTR: 
100492918
DRE: 
436909(khk)
TRU: 
101064289
OLA: 
101158269
BFO: 
BRAFLDRAFT_272474
CIN: 
100181324
SPU: 
588197
DME: 
Dmel_CG12289 Dmel_CG7328 Dmel_CG7335 Dmel_CG7551
DPO: 
Dpse_GA20264 Dpse_GA20271 Dpse_GA20433 Dpse_GA23880
DAN: 
Dana_GF24486 Dana_GF24487 Dana_GF24552 Dana_GF25264
DER: 
Dere_GG13341 Dere_GG13342 Dere_GG13921 Dere_GG15503
DPE: 
Dper_GL22794 Dper_GL22827 Dper_GL25057 Dper_GL25058
DSE: 
Dsec_GM22247 Dsec_GM22248 Dsec_GM24754 Dsec_GM25272
DSI: 
Dsim_GD12218 Dsim_GD12219 Dsim_GD12805 Dsim_GD14306
DWI: 
Dwil_GK17169 Dwil_GK17250 Dwil_GK19276
DYA: 
Dyak_GE20217 Dyak_GE21811 Dyak_GE22430 Dyak_GE22431
DGR: 
Dgri_GH14844 Dgri_GH15118 Dgri_GH15119
DMO: 
Dmoj_GI11611 Dmoj_GI13699 Dmoj_GI13769 Dmoj_GI13771
DVI: 
Dvir_GJ11289 Dvir_GJ13759 Dvir_GJ13760 Dvir_GJ14039
AGA: 
AgaP_AGAP002483
AAG: 
AaeL_AAEL006316
CQU: 
CpipJ_CPIJ012838
AME: 
726522
NVI: 
100115525(NV12585)
NVE: 
NEMVE_v1g199886
HMG: 
100206260
TAD: 
TRIADDRAFT_58015
AQU: 
100637048
NCR: 
NCU03742
SMP: 
SMAC_02593
PAN: 
PODANSg8149
TTT: 
THITE_2107054
MTM: 
MYCTH_2116851
FGR: 
FG07149.1
NHE: 
NECHADRAFT_48854
VAL: 
VDBG_04219
NFI: 
NFIA_022430
AOR: 
AOR_1_1534174(AO090005000876)
ANG: 
ANI_1_774014(An01g06030)
AFV: 
AFLA_081250
ACT: 
ACLA_032210
PCS: 
Pc22g22030
CIM: 
CIMG_03621
CPW: 
CPC735_006510
PBL: 
PAAG_01961
URE: 
UREG_06285
AJE: 
HCAG_00040
PNO: 
SNOG_00283
PTE: 
PTT_11946
PIF: 
PITG_02500
TCY: 
Thicy_1233
MEJ: 
Q7A_2986
MEC: 
Q7C_1302
NOC: 
Noc_2848
NHL: 
Nhal_0504
NWA: 
Nwat_0240
TMB: 
Thimo_2207
HHA: 
Hhal_0921
TGR: 
Tgr7_0113
TKM: 
TK90_0283
TNI: 
TVNIR_3462(ydjH_[C])
HNA: 
Hneap_0029
MOX: 
DAMO_2523(KHK)
 » show all
Taxonomy
Reference
1  [PMID:14858418]
  Authors
CORI GT, OCHOA S, SLEIN MW, CORI CF.
  Title
The metabolism of fructose in liver; isolation of fructose-I-phosphate and inorganic pyrophosphate.
  Journal
Biochim. Biophys. Acta. 7 (1951) 304-17.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:13208667]
  Authors
HERS HG.
  Title
[Liver fructokinase.]
  Journal
Biochim. Biophys. Acta. 8 (1952) 416-23.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:13449068]
  Authors
PARKS RE Jr, BEN-GERSHOM E, LARDY HA.
  Title
Liver fructokinase.
  Journal
J. Biol. Chem. 227 (1957) 231-42.
  Organism
Rattus norvegicus [GN:rno], Bos taurus [GN:bta]
Reference
4  [PMID:193556]
  Authors
Raushel FM, Cleland WW.
  Title
Bovine liver fructokinase: purification and kinetic properties.
  Journal
Biochemistry. 16 (1977) 2169-75.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-50-6
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