KEGG   ENZYME: 2.7.1.36Help
Entry
EC 2.7.1.36                 Enzyme                                 
Name mevalonate kinase;
mevalonate kinase (phosphorylating);
mevalonate phosphokinase;
mevalonic acid kinase;
mevalonic kinase;
mevalonate 5-phosphotransferase ;
MVA kinase;
ATP:mevalonate 5-phosphotransferase
Class Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname ATP:(R)-mevalonate 5-phosphotransferase
Reaction(IUBMB) ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate [RN:R02245]
Reaction(KEGG) R02245
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Substrate ATP [CPD:C00002];
(R)-mevalonate [CPD:C00418]
Product ADP [CPD:C00008];
(R)-5-phosphomevalonate [CPD:C01107]
Comment CTP, GTP and UTP can also act as donors.
Pathway PATH: ec00900  Terpenoid backbone biosynthesis
PATH: ec01062  Biosynthesis of terpenoids and steroids
PATH: ec01066  Biosynthesis of alkaloids derived from terpenoid and
               polyketide
PATH: ec01070  Biosynthesis of plant hormones
PATH: ec01100  Metabolic pathways
Orthology KO: K00869  mevalonate kinase
Genes HSA: 4598(MVK)
MCC: 707645(MVK)
MMU: 17855(Mvk)
RNO: 81727(Mvk)
CFA: 486309(MVK)
BTA: 505792(MVK)
SSC: 100152230
ECB: 100066619
MDO: 100016213(MVK)
OAA: 100090013
GGA: 768555(MVK)
TGU: 100229425
DRE: 492477
CIN: 100185592
SPU: 585785
DME: Dmel_CG33671
DPO: Dpse_GA24635
DAN: Dana_GF11467
DER: Dere_GG22565
DPE: Dper_GL11191
DSE: Dsec_GM20348
DSI: Dsim_GD25827
DYA: Dyak_GE13435
DGR: Dgri_GH20706
DMO: Dmoj_GI19067
AGA: AgaP_AGAP008947
AAG: AaeL_AAEL006435
CQU: CpipJ_CPIJ004201
AME: 552163
NVI: 100124176
TCA: 661052
API: 100163305
ISC: IscW_ISCW018716
CEL: Y42G9A.4
CBR: CBG21109
BMY: Bm1_46240
SMM: Smp_042980
NVE: NEMVE_v1g245688
TAD: TRIADDRAFT_59087
ATH: AT5G27450(MK)
POP: POPTR_680106 POPTR_729638
RCU: RCOM_0573350 RCOM_1431350
VVI: 100251148(GSVIVT00022848001)
OSA: 4348331(Os10g0329300)
SBI: SORBI_04g001220(SORBIDRAFT_04g001220)
ZMA: 100279817(pco073706b)
PPP: PHYPADRAFT_223169
SCE: YMR208W(ERG12)
AGO: AGOS_AER335W
KLA: KLLA0C07469g
LTH: KLTH0D12232g
DHA: DEHA0F12188g
PIC: PICST_40742(ERG12)
PPA: PAS_chr1-3_0187
VPO: Kpol_1064p33
LEL: LELG_00420
ZRO: ZYRO0F09328g
CAL: CaO19.12272(ERG12)
CTP: CTRG_03414
CDU: CD36_08920
CGR: CAGL0F03861g
YLI: YALI0B16038g
SPO: SPAC13G6.11c(erg12)
NCR: NCU03633
PAN: PODANSg8779
MGR: MGG_06946
FGR: FG05912.1
ANI: AN3869.2
AFM: AFUA_4G07780
AOR: AO090023000793
ANG: An04g02190
AFV: AFLA_112040
PCS: Pc13g07140
NFI: NFIA_108390
CIM: CIMG_05726
URE: UREG_04741
SSL: SS1G_06081
BFU: BC1G_01429
CNE: CNK01740
CNB: CNBK1800
ECU: ECU09_1780
DDI: DDBDRAFT_0168621
TET: TTHERM_00637680
PTM: GSPATT00003653001 PTMB.192
TBR: Tb927.4.4070
TCR: 436521.9 509237.10
LMA: LmjF31.0560
LIF: LinJ31.1230
LBZ: LbrM31_V2.0720
GLA: GL50803_4964
TVA: TVAG_424580
PTI: PHATRDRAFT_53929(MK)
TPS: THAPSDRAFT_2376
TTU: TERTU_3248(mvk)
CBU: CBU_0608 CBU_0609
CBS: COXBURSA331_A0721(mvk) COXBURSA331_A0722
CBD: CBUD_0620(mvk) CBUD_0621
CBG: CbuG_1394 CbuG_1395(mvk)
CBC: CbuK_1441 CbuK_1442(mvk)
LPN: lpg2039
LPF: lpl2017
LPP: lpp2022
LPC: LPC_1525
DNO: DNO_0489
BBA: Bd1027(lmbP) Bd1630(mvk)
MXA: MXAN_5019(mvk)
SCL: sce4205(mvk)
HOH: Hoch_3409
LAS: CLIBASIA_04595 CLIBASIA_04600
OIH: OB0225
SAU: SA0547(mvaK1)
SAV: SAV0590(mvaK1)
SAW: SAHV_0588(mvaK1)
SAM: MW0545(mvaK1)
SAR: SAR0596(mvaK1)
SAS: SAS0549
SAC: SACOL0636(mvk)
SAB: SAB0540(mvaK1)
SAA: SAUSA300_0572(mvk)
SAX: USA300HOU_0583(mvaK1)
SAO: SAOUHSC_00577
SAJ: SaurJH9_0613
SAH: SaurJH1_0628
SAE: NWMN_0553(mvaK1)
SAD: SAAV_0552(mvk)
SEP: SE0361
SER: SERP0238(mvk)
SHA: SH2402(mvaK1)
SSP: SSP2122
SCA: Sca_0244(mvaK1)
LMO: lmo0010
LMF: LMOf2365_0011
LMH: LMHCC_2653(mvk)
LMC: Lm4b_00010
LIN: lin0010
LWE: lwe0011(mvk)
LLA: L7866(yeaG)
LLK: LLKF_0456(mvaK)
LLC: LACR_0454
LLM: llmg_0425(mvk)
SPY: SPy_0876(mvaK1)
SPZ: M5005_Spy_0682(mvaK1)
SPM: spyM18_0937(mvaK1)
SPG: SpyM3_0595(mvaK1)
SPS: SPs1258
SPH: MGAS10270_Spy0740(mvaK1)
SPI: MGAS10750_Spy0774(mvaK1)
SPJ: MGAS2096_Spy0753(mvaK1)
SPK: MGAS9429_Spy0737(mvaK1)
SPF: SpyM51126(mvaK1)
SPA: M6_Spy0699
SPB: M28_Spy0662(mvaK1)
SOZ: Spy49_0690(mvaK1)
SPN: SP_0381
SPD: SPD_0346(mvk)
SPR: spr0338(mvk)
SPW: SPCG_0376(mvk)
SPX: SPG_0346(mvaK1)
SNE: SPN23F_03530(mvaK1)
SPV: SPH_0488(mvk)
SNM: SP70585_0452(mvk)
SJJ: SPJ_0368(mvk)
SPP: SPP_0419(mvk)
SNT: SPT_0426(mvk)
SAG: SAG1326
SAN: gbs1396
SAK: SAK_1357(mvk)
SMU: SMU.181
STC: str0559(mvaK1)
STL: stu0559(mvaK1)
STE: STER_0598
SSA: SSA_0333(mvaK1)
SSU: SSU05_0289
SSV: SSU98_0285
SSB: SSUBM407_0260(mvaK1)
SSI: SSU0269(mvaK1)
SSS: SSUSC84_0258(mvaK1)
SGO: SGO_0239(mvk)
SEQ: SZO_08830
SEZ: Sez_1084(mvk)
SEU: SEQ_1104
SUB: SUB0765(mvaK1)
SDS: SDEG_0833(mvaK1)
LPL: lp_1735(mvaK1)
LPJ: JDM1_1458(mvaK1)
LJO: LJ1205
LJF: FI9785_975(mvk)
LAC: LBA1167(mvaK)
LSA: LSA0908(mvaK1)
LSL: LSL_0685(eRG)
LDB: Ldb0999(mvk)
LBU: LBUL_0906
LBR: LVIS_0858
LCA: LSEI_1491
LCB: LCABL_17130(mvaK1)
LGA: LGAS_1033
LRE: Lreu_0915
LRF: LAR_0862
LHE: lhv_1275
LFE: LAF_1192
LRH: LGG_01498(mvaK1)
LRL: LC705_01513(mvaK1)
PPE: PEPE_0927
EFA: EF0904(mvk)
OOE: OEOE_1100
LME: LEUM_1385
LCI: LCK_00646(mvk)
ACL: ACL_0800(mvaK1)
MUL: MUL_3525(erg12)
MMI: MMAR_3217(erg12)
CKP: ckrop_0026(mvaK1)
NFA: nfa22070
BBZ: BbuZS7_0708(mvk)
BGA: BG0711
BAF: BAPKO_0732
BTU: BT0688
BHR: BH0688
BDU: BDU_691(mvaK)
BRE: BRE_694(mvaK)
GFO: GFO_3629
FJO: Fjoh_1387
FPS: FP0313
FBA: FIC_00967
COC: Coch_0622
RBI: RB2501_08650
BBL: BLBBGE_085(mvaK)
BPI: BPLAN_549(mvaK)
LBA: Lebu_0142
SMF: Smon_1124
RRS: RoseRS_2135
RCA: Rcas_1736
CAU: Caur_0880
CAG: Cagg_2461
CHL: Chy400_0955
HAU: Haur_4315
TTR: Tter_2002
MJA: MJ1087
MFE: Mefer_1345
MVU: Metvu_0343
MMP: MMP1335
MMQ: MmarC5_0258
MMX: MmarC6_1338
MMZ: MmarC7_0580
MAE: Maeo_0775
MVN: Mevan_0646
MAC: MA0602(mvk)
MBA: Mbar_A1421
MMA: MM_1762
MBU: Mbur_2395
MTP: Mthe_0476
MHU: Mhun_2890
MLA: Mlab_0681
MEM: Memar_1812
MBN: Mboo_2213
MPL: Mpal_2376
MPD: MCP_1639(mvk)
MTH: MTH46
MST: Msp_0858(mvk)
MSI: Msm_1439
MKA: MK0993(ERG12)
AFU: AF2289(mvk)
HAL: VNG1145G(mvk)
HSL: OE2645F(mvk)
HMA: rrnAC0077(mvk)
HWA: HQ2925A(mvk)
NPH: NP2850A(mvk)
HLA: Hlac_1829
HUT: Huta_2045
HMU: Hmuk_2604
PTO: PTO1352
PHO: PH1625
PAB: PAB0372(mvk)
PFU: PF1637
TKO: TK1474
TON: TON_0133
TGA: TGAM_1728(mvk)
TSI: TSIB_1226
RCI: LRC399(mvk)
APE: APE_2439(mvk)
SMR: Smar_0218
IHO: Igni_0758
DKA: DKAM_0131
HBU: Hbut_0877
SSO: SSO0383
STO: ST2185
SAI: Saci_2365(mvk)
SIS: LS215_1862
SIA: M1425_1722
SIM: M1627_1840
SID: M164_1769
SIY: YG5714_1838
SIN: YN1551_1087
MSE: Msed_1602
PAI: PAE3108
PIS: Pisl_0467
PCL: Pcal_1835
PAS: Pars_1599
CMA: Cmaq_0966
TNE: Tneu_1653
TPE: Tpen_0891
NMR: Nmar_0315
KCR: Kcr_1067
Taxonomy
Structures PDB: 1KKH  1KVK  1VIS  2HFS  2HFU  2OI2  2R3V  2R42  
Reference
  Authors
  Title

  Journal
 1
Hellig, H. and Popjak, G.
Studies on the biosynthesis of cholesterol. XIII. Phosphomevalonic
kinase from liver.
J. Lipid Res. 2 (1961) 235-243.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:14416398]
LEVY HR, POPJAK G.
Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase
from liver.
Biochem. J. 75 (1960) 417-28.
Sus scofa [GN:ssc]
Reference
  Authors
  Title
  Journal
 3
Markley, K. and Smallman, E.
Mevalonic kinase in rabbit liver.
Biochim. Biophys. Acta 47 (1961) 327-335.
Reference
  Authors
  Title
  Journal
  Organism
 4  [PMID:13598740]
TCHEN TT.
Mevalonic kinase: purification and properties.
J. Biol. Chem. 233 (1958) 1100-3.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 2.7.1.36
IUBMB Enzyme Nomenclature: 2.7.1.36
ExPASy - ENZYME nomenclature database: 2.7.1.36
BRENDA, the Enzyme Database: 2.7.1.36
CAS: 9026-52-2
DBGET integrated database retrieval system