KEGG   ENZYME: 2.7.1.49Help
Entry
EC 2.7.1.49                 Enzyme                                 
Name hydroxymethylpyrimidine kinase;
hydroxymethylpyrimidine kinase (phosphorylating)
Class Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase
Reaction(IUBMB) ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP +
4-amino-5-phosphonooxymethyl-2-methylpyrimidine [RN:R03471]
Reaction(KEGG) R03471
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Substrate ATP [CPD:C00002];
4-amino-5-hydroxymethyl-2-methylpyrimidine [CPD:C01279]
Product ADP [CPD:C00008];
4-amino-5-phosphonooxymethyl-2-methylpyrimidine
Comment CTP, UTP and GTP can act as donors.
Pathway PATH: ec00730  Thiamine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00877  hydroxymethylpyrimidine kinase
Genes ECO: b2103(thiD)
ECJ: JW2090(thiD)
ECD: ECDH10B_2256(thiD)
EBW: BWG_1889(thiD)
ECE: Z3267(thiD)
ECS: ECs2906
ECF: ECH74115_3082(thiD)
ETW: ECSP_2898(thiD)
ECG: E2348C_2248(thiD)
ECC: c2630(thiD)
ECI: UTI89_C2377(thiD)
ECP: ECP_2141
ECV: APECO1_4442(thiD)
ECW: EcE24377A_2391(thiD)
ECX: EcHS_A2239(thiD)
ECM: EcSMS35_0961(thiD)
ECY: ECSE_2372
ECL: EcolC_1544
ECK: EC55989_2358(thiD)
ECQ: ECED1_2459(thiD)
ECR: ECIAI1_2177(thiD)
ECT: ECIAI39_0914(thiD)
ECZ: ECS88_2245(thiD)
EUM: ECUMN_2435(thiD)
ELF: LF82_2247(thiD)
EBL: B21_01995(thiD)
EBD: ECBD_1554
EBR: ECB_02031(thiD)
EOH: ECO103_2579(thiD)
EOI: ECO111_2819(thiD)
EOJ: ECO26_3012(thiD)
EFE: EFER_2189(thiD)
STY: STY2375(thiD)
STT: t0710(thiD)
SPT: SPA0706(thiD)
SEK: SSPA0665
SPQ: SPAB_00877
SEI: SPC_1557(thiD)
SEC: SC2161(thiD)
SEH: SeHA_C2378(thiD)
SEE: SNSL254_A2333(thiD)
SEW: SeSA_A2382(thiD)
SEA: SeAg_B2289(thiD)
SED: SeD_A2490(thiD)
SEG: SG2179(thiD)
SET: SEN2142(thiD)
SES: SARI_00753
STM: STM2146(thiD)
YPE: YPO2859(thiD)
YPK: y1373(thiD)
YPM: YP_2725(thiD)
YPA: YPA_2299
YPN: YPN_1278
YPG: YpAngola_A3091(thiD)
YPP: YPDSF_2209
YPS: YPTB2824(thiD)
YPI: YpsIP31758_1203(thiD)
YPY: YPK_1321
YPB: YPTS_2930
YEN: YE1088(thiD)
SFL: SF2165(thiD)
SFX: S2290(thiD)
SFV: SFV_2158(thiD)
SSN: SSON_2151(thiD)
SBO: SBO_0924(thiD)
SBC: SbBS512_E1135(thiD)
SDY: SDY_2277(thiD)
ECA: ECA3196(thiD)
PCT: PC1_2979
PWA: Pecwa_1301
ETA: ETA_13040(thiD)
PLU: plu2782(thiD)
PAY: PAU_01757(thiD)
WBR: WGLp318(thiD)
ENT: Ent638_2710
ESA: ESA_01134
CTU: Ctu_27790(thiD)
KPN: KPN_02550(thiD)
KPE: KPK_1619(thiD)
KPU: KP1_3768(thiD)
CKO: CKO_00681
SPE: Spro_3577
PMR: PMI1593(thiD)
EIC: NT01EI_1153
ETR: ETAE_1059(thiD)
DDA: Dd703_2711
DDC: Dd586_3011
DZE: Dd1591_1191
HIN: HI0416(thiD)
HIT: NTHI0541(thiD)
HIP: CGSHiEE_00915
HAP: HAPS_1840(thiD)
HSO: HS_0091(thiD)
PMU: PM1261(thiD)
MSU: MS0677(thiD)
APL: APL_0539(thiD)
APA: APP7_0581
ASU: Asuc_1507
AAP: NT05HA_0532
AAT: D11S_1152
XFA: XF0621
XFT: PD1534(thiD)
XFM: Xfasm12_1688
XFN: XfasM23_1619
XCC: XCC1735(thiD)
XCB: XC_2499
XCA: xccb100_2526
XCV: XCV1784(thiD)
XAC: XAC1753(thiD)
XOO: XOO2928(thiD)
XOM: XOO_2780
XOP: PXO_00132(thiD)
SML: Smlt1767(thiD)
SMT: Smal_1505
VCH: VC1296
VCO: VC0395_A0914(thiD)
VCM: VCM66_1251(thiD)
VCJ: VCD_003055
VVU: VV2_1433
VVY: VVA0267
VPA: VPA0136
VHA: VIBHAR_06838
VSP: VS_II1090
VEX: VEA_000863
VFI: VF_A0316(thiD)
VFM: VFMJ11_A0354(thiD)
VSA: VSAL_II0486(thiD)
PPR: PBPRB0688
PAE: PA3975(thiD)
PAU: PA14_12410(thiD)
PAP: PSPA7_1133(thiD)
PAG: PLES_10001(thiD)
PPU: PP_4782(thiD)
PPF: Pput_4658
PPG: PputGB1_4836
PPW: PputW619_0638
PST: PSPTO_4798
PSB: Psyr_4340
PSP: PSPPH_4382
PFL: PFL_5427(thiD)
PFO: Pfl01_4945
PFS: PFLU5399
PEN: PSEEN4802(thiD)
PMY: Pmen_3772
PSA: PST_3756(thiD)
CJA: CJA_2910(thiD)
AVN: Avin_09280(thiD)
PAR: Psyc_0167(thiD)
PCR: Pcryo_0179
PRW: PsycPRwf_0828
ACI: ACIAD0875(thiD)
ACB: A1S_0821
ABM: ABSDF2637(thiD)
ABY: ABAYE2989(thiD)
ABC: ACICU_00779
ABN: AB57_0874
ABB: ABBFA_002791
PIN: Ping_2378
TTU: TERTU_3067 TERTU_3925(thiD)
TCX: Tcr_0143
NOC: Noc_1265
TGR: Tgr7_2419
HNA: Hneap_1513
TAU: Tola_0217
AFE: Lferr_2903
AFR: AFE_3305
BCI: BCI_0649(thiD)
RMA: Rmag_0954
VOK: COSY_0854(thiD)
NMA: NMA1815(thiD)
NME: NMB1616(thiD)
NMC: NMC1538(thiD)
NMN: NMCC_1525(thiD)
NMI: NMO_1443(thiD)
NGO: NGO1160
NGK: NGK_2018
CVI: CV_0151(thiD)
LHK: LHK_00016 LHK_02660
RSO: RSc0100(thiD)
RPI: Rpic_3651
RPF: Rpic12D_3328
REH: H16_A0243
RME: Rmet_0169
CTI: RALTA_A0187(thiD)
BMA: BMA1577(thiD) BMA2000
BMV: BMASAVP1_A0913 BMASAVP1_A2080(thiD)
BML: BMA10229_A2743 BMA10229_A3232(thiD)
BMN: BMA10247_1352(thiD) BMA10247_1862
BPS: BPSL2181(thiD) BPSL2696 BPSS1104
BPM: BURPS1710b_2604(thiD) BURPS1710b_3174(thiD)
     BURPS1710b_A0060(thiD2)
BPL: BURPS1106A_2516(thiD) BURPS1106A_3152
BPD: BURPS668_2460(thiD) BURPS668_3116
BPR: GBP346_A2585(thiD_1) GBP346_A3295
BTE: BTH_I1459 BTH_I2005(thiD)
BVI: Bcep1808_1947
BUR: Bcep18194_A3959 Bcep18194_A5350
BCN: Bcen_6036
BCH: Bcen2424_2041
BCM: Bcenmc03_0832 Bcenmc03_2060
BCJ: BCAL2112(thiD) BCAL3145
BAM: Bamb_2073
BAC: BamMC406_0751 BamMC406_1942
BMU: Bmul_1236 Bmul_2527
BMJ: BMULJ_00711(thiD) BMULJ_02011(thiD)
BXE: Bxe_A1658 Bxe_A3814
BPH: Bphy_1361 Bphy_2331
BPY: Bphyt_0865 Bphyt_2479
BGL: bglu_1g07160 bglu_1g12490 bglu_2g17500
PNU: Pnuc_0889
BPE: BP3598(thiD)
BPA: BPP3987(thiD)
BBR: BB4460(thiD)
BPT: Bpet0490(thiD1) Bpet0559(thiD2)
BAV: BAV3014(thiD) BAV3070(thiD)
RFR: Rfer_2470
POL: Bpro_1134 Bpro_2331
PNA: Pnap_2435 Pnap_3356
AAV: Aave_0899 Aave_3067
AJS: Ajs_1787 Ajs_3580
VEI: Veis_3023 Veis_4315
DAC: Daci_1570 Daci_3294
DIA: Dtpsy_1935 Dtpsy_2903
VAP: Vapar_2399 Vapar_4628
CTT: CtCNB1_2975 CtCNB1_3991
MPT: Mpe_A3192
HAR: HEAR2749(thiD-like)
MMS: mma_1216(thiD1) mma_2958(thiD2)
LCH: Lcho_2204 Lcho_3973
NEU: NE1425(thiD)
NMU: Nmul_A2627
EBA: ebA1745(thiD)
DAR: Daro_3900
TBD: Tbd_2555
MFA: Mfla_0853
MMB: Mmol_2312
MEI: Msip34_1289 Msip34_2800
APP: CAP2UW1_3584
HPY: HP0844
HPJ: jhp0782(thiD)
HPS: HPSH_02580
HPG: HPG27_802
HPB: HELPY_0511(thiD)
CJE: Cj1082c(thiD)
CJR: CJE1225(thiD)
CJJ: CJJ81176_1100(thiD)
CJU: C8J_1023(thiD)
CJD: JJD26997_0641(thiD)
CFF: CFF8240_0969(thiD)
CCV: CCV52592_0496(thiD)
CHA: CHAB381_1498(thiD)
CCO: CCC13826_0361(thiD)
CLA: Cla_1124(thiD)
ABU: Abu_1756(thiD)
SDL: Sdel_1176
SUN: SUN_0531(thiD)
GUR: Gura_3851
GLO: Glov_2763
GBM: Gbem_3462
GEO: Geob_1418
GEM: GM21_3528
DVU: DVU0931(thiD)
DVL: Dvul_2054
DVM: DvMF_1376
DDE: Dde_2688
DDS: Ddes_0699
DMA: DMR_25260(thiD)
DSA: Desal_1774
LIP: LI0782(thiD)
DBA: Dbac_0928
DRT: Dret_2294
DPS: DP0916
DOL: Dole_2517
DAL: Dalk_0775
DAT: HRM2_04290
AFW: Anae109_1765
SCL: sce0656(thiD)
HOH: Hoch_2426
SAT: SYN_01521
NRI: NRI_0911
MLO: mll5788
MES: Meso_2566
PLA: Plav_2132
SME: SM_b20962(thiD)
SMD: Smed_4962
ATU: Atu3290(thiD)
ATC: AGR_L_3056
ARA: Arad_9221(thiD)
AVI: Avi_0372(thiD)
REC: RHECIAT_PA0000265(thiD)
RLE: pRL110441(thiD)
RLT: Rleg2_5777
RLG: Rleg_6681
RHI: NGR_b18410(thiD)
BME: BMEI1732
BMF: BAB1_0219
BMB: BruAb1_0213(thiD)
BMC: BAbS19_I02060
BMS: BR0218(thiD)
BMT: BSUIS_A0217(thiD)
BOV: BOV_0209(thiD)
BCS: BCAN_A0220(thiD)
BMR: BMI_I221(thiD)
OAN: Oant_0285
BJA: bll5905(thiD)
BRA: BRADO5133(thiD)
BBT: BBta_5600(thiD)
RPA: RPA3971(thiD)
RPB: RPB_1617
RPD: RPD_1628
RPE: RPE_1463
RPT: Rpal_4493
NWI: Nwi_1082
NHA: Nham_1310
OCA: OCAR_5343(thiD)
BHE: BH16280(thiD2)
BQU: BQ13200(thiD2)
BBK: BARBAKC583_0441(thiD)
BTR: Btr_0761(thiD1) Btr_2648(thiD2)
BGR: Bgr_05670(thiD1) Bgr_19900(thiD2)
XAU: Xaut_4453
AZC: AZC_1826
MEX: Mext_4470
MEA: Mex_1p4915(thiD)
MDI: METDI5506(thiD)
MRD: Mrad2831_1958
MET: M446_4939
MPO: Mpop_4984
MCH: Mchl_4934
MNO: Mnod_4968
BID: Bind_0125
MSL: Msil_3018
CCR: CC_3223
CCS: CCNA_03331
CAK: Caul_4475
PZU: PHZ_c3281(thiD)
SIL: SPO0045(thiD)
RSP: RSP_0647(thiD)
RSH: Rsph17029_2300
RSQ: Rsph17025_0585
RSK: RSKD131_2004
RDE: RD1_0746(thiD) RD1_3612(thiD)
DSH: Dshi_0915(thiD)
MMR: Mmar10_0552
HBA: Hbal_2405
ZMN: Za10_0302
SWI: Swit_0082
GBE: GbCGDNIH1_1113
GDI: GDI_0813(thiED)
GDJ: Gdia_1204
APT: APA01_13250
RCE: RC1_1793(thiD)
BSU: BSU11710(yjbV)
BHA: BH1435
BAN: BA0734(thiD-1)
BAR: GBAA0734(thiD-1)
BAA: BA_1322(pfkB)
BAT: BAS0700
BAH: BAMEG_3825(thiD1)
BAI: BAA_0841(thiD1)
BCE: BC0751
BCA: BCE_0804(thiD)
BCZ: BCZK0644(thiD)
BCR: BCAH187_A0888(thiD1)
BCB: BCB4264_A0791(thiD1)
BCU: BCAH820_0811(thiD1)
BCG: BCG9842_B4540(thiD1)
BCQ: BCQ_0825(thiD)
BCX: BCA_0797(thiD1)
BCY: Bcer98_0621
BTK: BT9727_0644(thiD)
BTL: BALH_0671(thiD)
BWE: BcerKBAB4_0650
BLI: BL01586(yjbV)
BAY: RBAM_011720(yjbV)
BPU: BPUM_1100(thiDA)
OIH: OB0474
GTN: GTNG_1361
GWC: GWCH70_1938
GYM: GYMC10_1138
GYC: GYMC61_2346
AFL: Aflv_2311
LMO: lmo0317
LMF: LMOf2365_0335(thiD-1)
LMH: LMHCC_2316(thiD)
LMC: Lm4b_00336
LIN: lin0342
LWE: lwe0288
LSP: Bsph_4148
ESI: Exig_0540
EAT: EAT1b_1528
BBE: BBR47_21230(thiD)
PJD: Pjdr2_5398
AAC: Aaci_1932
LLK: LLKF_1329(thiD)
LLC: LACR_1376
LPJ: JDM1_0114(thiD)
LCB: LCABL_03170(thiD)
LRE: Lreu_1014
LRF: LAR_0969
LFE: LAF_0802
LRH: LGG_00370(thiD)
LRL: LC705_00360(thiD)
LCI: LCK_00281(thiD)
CAC: CAC3095(thiK)
CPE: CPE1338(thiD)
CPF: CPF_1545(thiD)
CPR: CPR_1338(thiD)
CTC: CTC01753
CNO: NT01CX_0246(thiD)
CDF: CD1599(thiD)
CDC: CD196_1522(thiD)
CDL: CDR20291_1497(thiD)
CBO: CBO0451(thiD1) CBO0771(thiD2)
CBA: CLB_0492(thiD-1) CLB_0813(thiD-2)
CBH: CLC_0525(thiD-1) CLC_0827(thiD-2)
CBY: CLM_0533(thiD) CLM_0921(thiD)
CBL: CLK_0179(thiD) CLK_3654(thiD)
CBK: CLL_A3106(thiD)
CBB: CLD_0291(thiD) CLD_3793(thiD)
CBI: CLJ_B0523(thiD_1) CLJ_B0820(thiD_2)
CBT: CLH_2857(thiD)
CBF: CLI_0536(thiD-1) CLI_0857(thiD-2)
CBE: Cbei_4490
CKL: CKL_2919(thiD)
CKR: CKR_2589
CCE: Ccel_1992
AMT: Amet_1249
AOE: Clos_2695
STH: STH156
SWO: Swol_0639
ATE: Athe_0381
DSY: DSY1405
DHD: Dhaf_2522
DRM: Dred_0071
DAE: Dtox_1670
PTH: PTH_0925(thiD)
FMA: FMG_0202
APR: Apre_1397
EEL: EUBELI_01399 EUBELI_20048
ERE: EUBREC_2528
TTE: TTE2235(thiD)
TEX: Teth514_0565
TPD: Teth39_1656
CPO: COPRO5265_0004(thiD)
NTH: Nther_2484
MTU: Rv0422c(thiD)
MTC: MT0436(thiD)
MTF: TBFG_10427
MTB: TBMG_00423(TBMG_00423.1)
MBO: Mb0430c(thiD)
MBT: JTY_0431(thiD)
MLE: ML0295(thiD)
MLB: MLBr_00295(thiD)
MPA: MAP3912c(thiD)
MAV: MAV_4732(thiD)
MUL: MUL_3599(thiD)
MAB: MAB_4197
MMI: MMAR_0734(thiD)
CGL: NCgl1407(cgl1463)
CEF: CE1591
CJK: jk0297(thiD)
CUR: cur_0377
CAR: cauri_1292(thiD)
CKP: ckrop_1703(thiD)
RER: RER_14870(thiD)
GBR: Gbro_0649
SCO: SCO5563(SC7A1.07)
SMA: SAV_7205(thiD)
SGR: SGR_1917
ACH: Achl_2146
RSA: RSal33209_3251
MLU: Mlut_07930
BFA: Bfae_08080 Bfae_27340
JDE: Jden_1183
KSE: Ksed_03000
XCE: Xcel_1453
PAC: PPA0110
TFU: Tfu_2250
TCU: Tcur_3441
SRO: Sros_8003
FRA: Francci3_3612
FRE: Franean1_1127
FAL: FRAAL5819(thiD)
NML: Namu_1288
KRA: Krad_0854
SEN: SACE_1297(thiD)
SAQ: Sare_4275
CAI: Caci_8032
BLO: BL0113(thiD)
BLJ: BLD_0131(thiD)
BLN: Blon_0794
BAD: BAD_1146(thiD)
BLA: BLA_0815(thiD)
BLC: Balac_1237
BLT: Balat_1237
AFO: Afer_1155
CCU: Ccur_09330
ELE: Elen_2061
LIL: LA0130(thiD)
LBI: LEPBI_I0567(thiD)
LBF: LBF_0548(thiD)
BHY: BHWA1_01268(thiD)
ACA: ACP_0903(thiD)
BTH: BT_0790
BFR: BF2259
BFS: BF2353(thiD)
BVU: BVU_3988
PDI: BDI_1062
APS: CFPG_631
RMR: Rmar_2095
CHU: CHU_0241(thiD)
DFE: Dfer_4828
CPI: Cpin_0623
PHE: Phep_2468
FJO: Fjoh_1601
FPS: FP0430(thiD)
FSU: Fisuc_0017
FNU: FN1759
STR: Sterm_1153
MIN: Minf_1574(thiD)
AMU: Amuc_0223
GAU: GAU_3709(thiE)
TAI: Taci_1709
AVA: Ava_3519
PMB: A9601_03951(thiD)
PMC: P9515_04031(thiD)
PMG: P9301_03941(thiD)
PMH: P9215_04001(thiD)
CTE: CT1176(thiD)
CPC: Cpar_1119
CPB: Cphamn1_1281
CLI: Clim_1407
PPH: Ppha_1501
PAA: Paes_1004
CTS: Ctha_2041
RRS: RoseRS_1921
RCA: Rcas_4126
CAU: Caur_0373
CAG: Cagg_3167
CHL: Chy400_0399
HAU: Haur_2438
TRO: trd_0398(thiD)
STI: Sthe_1496
DRA: DR_A0171
DGE: Dgeo_1919
DDR: Deide_04550(thiD)
TTH: TTC0321
TTJ: TTHA0680
HYA: HY04AAS1_0300
SUL: SYO3AOP1_0706
SAF: SULAZ_0039(thiD)
PMX: PERMA_1664(thiD)
TMA: TM0790
TPT: Tpet_0139
TLE: Tlet_1753
TRQ: TRQ2_0137
TNA: CTN_1788
TNP: Tnap_0140
TME: Tmel_1594
TAF: THA_1801
FNO: Fnod_1419
DTH: DICTH_1554
DTU: Dtur_1662
TYE: THEYE_A1264(thiD)
TTR: Tter_0647
MJA: MJ0236
MFE: Mefer_0443
MVU: Metvu_1681
MMX: MmarC6_1032
MMZ: MmarC7_0912
MAE: Maeo_0460
MVN: Mevan_0944
MAC: MA3197(thiD)
MBA: Mbar_A3501
MMA: MM_0338
MBU: Mbur_2182
MTP: Mthe_0828
MPL: Mpal_1249
MPD: MCP_2509(thiD)
MSI: Msm_0289
MKA: MK0589(thiD)
AFU: AF2208(thiD)
HAL: VNG2606G(thiD)
HSL: OE4654F(thiDN)
HMA: rrnAC2449(thiD)
NPH: NP0546A(thiD)
HLA: Hlac_2988
HUT: Huta_0491
HMU: Hmuk_0364
TAC: Ta1281
PHO: PH1155
PAB: PAB1646(thiD)
PFU: PF1333
TKO: TK0435
TGA: TGAM_1271(thiD)
TSI: TSIB_0462
APE: APE_2400.1(thiDN)
SMR: Smar_0049
IHO: Igni_0888
DKA: DKAM_0714
HBU: Hbut_1459
SSO: SSO2393(thiD-2)
STO: ST0526
SAI: Saci_0953
SIS: LS215_0216
SIA: M1425_0185
SIM: M1627_0185
SID: M164_0204
SIY: YG5714_0189
SIN: YN1551_2791
MSE: Msed_0646
PAI: PAE2535
PIS: Pisl_1419
PCL: Pcal_0240
PAS: Pars_0839
CMA: Cmaq_0452
TNE: Tneu_1881
NMR: Nmar_0542
KCR: Kcr_0867
Taxonomy
Reference
  Authors
  Title


  Journal
 1
Lewin, L.M. and Brown, G.M.
The biosynthesis of thiamine. III. Mechanism of enzymatic formation
of the pyrophosphate ester of
2-methyl-4-amino-5-hydroxymethylpyrimidine.
J. Biol. Chem. 236 (1961) 2768-2771.
Other DBs ExplorEnz - The Enzyme Database: 2.7.1.49
IUBMB Enzyme Nomenclature: 2.7.1.49
ExPASy - ENZYME nomenclature database: 2.7.1.49
BRENDA, the Enzyme Database: 2.7.1.49
CAS: 9026-55-5
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