KEGG   ENZYME: 2.7.1.50Help
Entry
EC 2.7.1.50                 Enzyme                                 
Name hydroxyethylthiazole kinase;
hydroxyethylthiazole kinase (phosphorylating);
4-methyl-5-(beta-hydroxyethyl)thiazole kinase
Class Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase
Reaction(IUBMB) ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP +
4-methyl-5-(2-phosphonooxyethyl)thiazole [RN:R04448]
Reaction(KEGG) R04448
Show
Substrate ATP [CPD:C00002];
4-methyl-5-(2-hydroxyethyl)thiazole
Product ADP [CPD:C00008];
4-methyl-5-(2-phosphonooxyethyl)thiazole
Pathway PATH: ec00730  Thiamine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00878  hydroxyethylthiazole kinase
Genes ATH: AT3G24030
POP: POPTR_757923
RCU: RCOM_1023290
VVI: 100252894(GSVIVT00020443001)
OSA: 4325819(Os01g0363600)
SBI: SORBI_03g014470(SORBIDRAFT_03g014470)
PPP: PHYPADRAFT_161103
CRE: CHLREDRAFT_126905(THI10)
OLU: OSTLU_26755
SCE: YPL214C(THI6)
AGO: AGOS_AFL110C
KLA: KLLA0B02134g
DHA: DEHA0G01463g
CGR: CAGL0E05808g
YLI: YALI0C15554g
SPO: SPAC23H4.10c(thi4)
CNE: CNI03710
PFA: PFL1920c
PFD: PFDG_02793
PFH: PFHG_03975
PYO: PY04023
PKN: PKH_145760
PVX: PVX_100930
BBO: BBOV_IV011860
ECO: b2104(thiM)
ECJ: JW2091(thiM)
ECD: ECDH10B_2257(thiM)
EBW: BWG_1890(thiM)
ECE: Z3268(thiM)
ECS: ECs2907
ECF: ECH74115_3083(thiM)
ETW: ECSP_2899(thiM)
ECG: E2348C_2249(thiM)
ECC: c2631(thiM)
ECI: UTI89_C2378(thiM)
ECP: ECP_2142
ECV: APECO1_4441(thiM)
ECW: EcE24377A_2392(thiM)
ECX: EcHS_A2240(thiM)
ECM: EcSMS35_0960(thiM)
ECY: ECSE_2373
ECL: EcolC_1543
ECK: EC55989_2359(thiM)
ECQ: ECED1_2460(thiM)
ECR: ECIAI1_2178(thiM)
ECT: ECIAI39_0913(thiM)
ECZ: ECS88_2246(thiM)
EUM: ECUMN_2436(thiM)
ELF: LF82_2255(thiM)
EBL: B21_01996(thiM)
EBD: ECBD_1553
EBR: ECB_02032(thiM)
EOH: ECO103_2580(thiM)
EOI: ECO111_2820(thiM)
EOJ: ECO26_3013(thiM)
EFE: EFER_2190
STY: STY2376
STT: t0709
SPT: SPA0705(thiM)
SEK: SSPA0664
SPQ: SPAB_00876
SEI: SPC_1556(thiM)
SEC: SC2162(thiM)
SEH: SeHA_C2379(thiM)
SEE: SNSL254_A2334(thiM)
SEW: SeSA_A2383(thiM)
SEA: SeAg_B2290(thiM)
SED: SeD_A2491(thiM)
SEG: SG2180(thiM)
SET: SEN2143(thiM)
SES: SARI_00752
STM: STM2147(thiM)
YEN: YE3599(thiM)
SFL: SF2166(thiM)
SFX: S2291(thiM)
SFV: SFV_2159(thiM)
SSN: SSON_2152(thiM)
SBO: SBO_0925(thiM)
SBC: SbBS512_E1134(thiM)
SDY: SDY_2278(thiM)
ECA: ECA3197(thiM)
PCT: PC1_2980
PWA: Pecwa_1300
SGL: SG1739
ENT: Ent638_2711
ESA: ESA_01133
CTU: Ctu_27800(thiM)
KPN: KPN_02551(thiM)
KPE: KPK_1618(thiM)
KPU: KP1_3769(thiM)
CKO: CKO_00680
SPE: Spro_3578
EIC: NT01EI_1152
ETR: ETAE_1058(thiM)
DDA: Dd703_2712
DDC: Dd586_3012
DZE: Dd1591_1190
HIN: HI0415
HIT: NTHI0540(thiM)
HIP: CGSHiEE_00920
HIQ: CGSHiGG_05260
HAP: HAPS_1841(thiM)
HSO: HS_0092(thiM)
PMU: PM1262(thiM)
ASU: Asuc_1506
VPA: VPA0131
VHA: VIBHAR_06843
VSP: VS_II1085
VEX: VEA_000868
VFI: VF_A0321(thiM)
VFM: VFMJ11_A0359(thiM)
VSA: VSAL_II0491(thiM)
PPR: PBPRA2337
PRW: PsycPRwf_0830
ACI: ACIAD2011(thiM)
ACB: A1S_2095
ABM: ABSDF1644(thiM)
ABY: ABAYE1466(thiM)
ABC: ACICU_02291
ABN: AB57_2427
ABB: ABBFA_001371
PIN: Ping_2373
TAU: Tola_0219
DNO: DNO_0932
CVI: CV_0024
LHK: LHK_02662(thiM)
BPS: BPSS1135
BPM: BURPS1710b_A0097
BPD: BURPS668_A1601
BTE: BTH_II1271
BGL: bglu_1g15110
RFR: Rfer_2472
LCH: Lcho_2206
HPY: HP0845
HPJ: jhp0783(thiM)
HPA: HPAG1_0830
HPS: HPSH_02575
HPG: HPG27_803
HPB: HELPY_0510(thiM)
CLA: Cla_1123(thiM)
SDL: Sdel_1175
DVU: DVU2363(thiM)
DVL: Dvul_0899
DVM: DvMF_3006
DDE: Dde_1378
DDS: Ddes_0467
DMA: DMR_30770(thiM)
DBA: Dbac_0930
DRT: Dret_2104
DPS: DP0499
DOL: Dole_0749
DAL: Dalk_0685
DAT: HRM2_38120(thiM)
SAT: SYN_00303
SFU: Sfum_3507
ATU: Atu3288
ATC: AGR_L_3060
ARA: Arad_9219(thiM)
RET: RHE_PE00337(thiM)
REC: RHECIAT_PA0000267(thiM)
RLE: pRL110443(thiM)
RLT: Rleg2_5775
RLG: Rleg_6679
RSP: RSP_0649(thiM)
RSH: Rsph17029_2302
RSQ: Rsph17025_0583
RSK: RSKD131_2006
RDE: RD1_3610(thiM)
GBE: GbCGDNIH1_0300
BSU: BSU38300(thiM)
BHA: BH3349(thiK)
BAN: BA0376(thiM)
BAR: GBAA0376(thiM)
BAA: BA_0952
BAT: BAS0362
BAH: BAMEG_0442(thiM)
BAI: BAA_0439(thiM)
BCE: BC0419
BCA: BCE_0486(thiM)
BCZ: BCZK0348(thiM)
BCR: BCAH187_A0486(thiM)
BCB: BCB4264_A0439(thiM)
BCU: BCAH820_0419(thiM)
BCG: BCG9842_B4885(thiM)
BCQ: BCQ_0461(thiM)
BCX: BCA_0454(thiM)
BCY: Bcer98_0363
BTK: BT9727_0352(thiM)
BTL: BALH_0374(thiM)
BWE: BcerKBAB4_0357
BLI: BL03865(thiM)
BLD: BLi04052(thiM)
BCL: ABC2912(thiK)
BAY: RBAM_035560(thiM)
BPU: BPUM_3484(thiM)
OIH: OB0473 OB0643
GKA: GK1509(thiK)
GTN: GTNG_1360
GWC: GWCH70_1939
GYM: GYMC10_1137
GYC: GYMC61_2345
AFL: Aflv_1345(thiM)
SAU: SA1895(thiM)
SAV: SAV2092(thiM)
SAW: SAHV_2077(thiM)
SAM: MW2015(thiM)
SAR: SAR2181(thiM)
SAS: SAS1996
SAC: SACOL2084(thiM)
SAB: SAB1976c(thiM)
SAA: SAUSA300_2048(thiM)
SAO: SAOUHSC_02329
SAJ: SaurJH9_2129
SAH: SaurJH1_2167
SAE: NWMN_1996(thiM)
SAD: SAAV_2146(thiM)
SEP: SE1691
SER: SERP1699(thiM)
SHA: SH0942(thiM)
SSP: SSP0791
SCA: Sca_1594(thiM)
LMO: lmo0316
LMF: LMOf2365_0334(thiM)
LMH: LMHCC_2317(thiM)
LMC: Lm4b_00335
LIN: lin0341
LWE: lwe0287(thiM)
LSP: Bsph_4147
ESI: Exig_0541
EAT: EAT1b_1529
MCL: MCCL_1747(thiM)
BBE: BBR47_39270(thiM)
AAC: Aaci_1933
LLA: L94809(thiM)
LLK: LLKF_1330(thiM)
LLC: LACR_1377
LLM: llmg_1216(thiM)
SPN: SP_0717 SP_0724
SPD: SPD_0623(thiM) SPD_0630
SPR: spr0629(thiM) spr0636(thiM)
SPW: SPCG_0666(thiM) SPCG_0673(thiM)
SPX: SPG_0650(thiM) SPG_0657
SNE: SPN23F_06420(thiM) SPN23F_06490
SPV: SPH_0804(thiM) SPH_0811
SNM: SP70585_0764(thiM) SP70585_0771
SJJ: SPJ_0657(thiM) SPJ_0664
SPP: SPP_0728(thiM) SPP_0735
SNT: SPT_0733(thiM) SPT_0740
SAG: SAG0841(thiM)
SAN: gbs0859
SAK: SAK_0964(thiM)
SSU: SSU05_0734
SSV: SSU98_0733
SSB: SSUBM407_1145(thiM)
SSI: SSU0686(thiM)
SSS: SSUSC84_0652(thiM)
LPL: lp_0113(thiM)
LPJ: JDM1_0113(thiM)
LSA: LSA0059(thiM)
LBR: LVIS_2099
LCA: LSEI_0299
LCB: LCABL_03150(thiM)
LRE: Lreu_1013
LRF: LAR_0968
LFE: LAF_0803
LRH: LGG_00368(thiM)
LRL: LC705_00357
EFA: EF2777
LME: LEUM_0485 LEUM_0938
LCI: LCK_00280(thiM)
CAC: CAC3096(thiK)
CPE: CPE1337(thiM)
CPF: CPF_1544(thiM)
CPR: CPR_1337(thiM)
CTC: CTC01752
CNO: NT01CX_0247(thiM)
CDF: CD1600(thiK)
CDC: CD196_1523(thiK)
CDL: CDR20291_1498(thiK)
CBO: CBO0450(thiK) CBO2253
CBA: CLB_0491(thiM-1) CLB_2193(thiM-2)
CBH: CLC_0524(thiM-1) CLC_2176(thiM-2)
CBY: CLM_0532(thiM) CLM_2460(thiM)
CBL: CLK_1695(thiM) CLK_3653(thiM)
CBK: CLL_A3105(thiM)
CBB: CLD_0292(thiM) CLD_2322(thiM)
CBI: CLJ_B0522(thiM_1) CLJ_B2463
CBT: CLH_2856(thiM)
CBF: CLI_0535(thiM-1) CLI_2303(thiM-2)
CBE: Cbei_4488
CKL: CKL_2918(thiM)
CKR: CKR_2588
CCE: Ccel_1990
AMT: Amet_1248
AOE: Clos_2694
SWO: Swol_0640
DSY: DSY1402
DHD: Dhaf_2519
DRM: Dred_0594
DAE: Dtox_1671
DAU: Daud_0479
FMA: FMG_0377
APR: Apre_1629
ERE: EUBREC_2530
TTE: TTE2232(thiM)
TEX: Teth514_0567
TPD: Teth39_1654
CHY: CHY_0748(thiM)
MTA: Moth_2017
CPO: COPRO5265_0005(thiM)
NTH: Nther_2483
CGL: NCgl1408(cgl1464)
CGB: cg1655(thiM)
CGT: cgR_1525
CEF: CE1592
RER: RER_36400(thiM)
CMI: CMM_2115(thiM)
CMS: CMS_1103(thiM)
BFA: Bfae_27360
JDE: Jden_1181
KSE: Ksed_02960
PAC: PPA0885
NML: Namu_5186
KRA: Krad_0852
BLO: BL0115(thiM)
BLJ: BLD_0133(thiM)
BLN: Blon_0797
BAD: BAD_1144(thiM)
BLA: BLA_0814(thiM)
BLC: Balac_1236
BLT: Balat_1236
RXY: Rxyl_2790
CCU: Ccur_09350
ELE: Elen_2063
CCA: CCA00204(thiM)
CAB: CAB199(thiM)
CFE: CF0803(thiM)
LIL: LA3365(thiM)
LIC: LIC10800(thiM)
LBJ: LBJ_0526
LBL: LBL_2553
LBI: LEPBI_I2714(thiM)
LBF: LBF_2630
BHY: BHWA1_00131(thiM)
DFE: Dfer_4826
STR: Sterm_1154
AMU: Amuc_2016
GAU: GAU_3710(thiM)
TAI: Taci_1710
CTS: Ctha_1684
RRS: RoseRS_1926
RCA: Rcas_4122
CAU: Caur_0375
CAG: Cagg_3165
CHL: Chy400_0401
HAU: Haur_2444
TTR: Tter_0648
MMP: MMP1138(thiM)
MMQ: MmarC5_0447
MMX: MmarC6_1530
MMZ: MmarC7_0389
MVN: Mevan_0460
MAC: MA2723(thiM)
MBA: Mbar_A3319
MMA: MM_3234
MHU: Mhun_2217
MLA: Mlab_1656
MEM: Memar_0262
MBN: Mboo_2055
MPL: Mpal_1692
MPD: MCP_1135(thiM)
MST: Msp_0682(thiM1) Msp_0694(thiM2)
MSI: Msm_0916
AFU: AF2075(thiM)
HWA: HQ2656A(thiM)
NPH: NP4052A(thiM)
PHO: PH1157
PAB: PAB2432(thiM)
PFU: PF1335
TSI: TSIB_0465
RCI: RCIX2677(thiM)
CMA: Cmaq_0062
Taxonomy
Structures PDB: 1C3Q  1EKK  1EKQ  1ESJ  1ESQ  3HPD  
Reference
  Authors
  Title


  Journal
 1
Lewin, L.M. and Brown, G.M.
The biosynthesis of thiamine. III. Mechanism of enzymatic formation
of the pyrophosphate ester of
2-methyl-4-amino-5-hydroxymethylpyrimidine.
J. Biol. Chem. 236 (1961) 2768-2771.
Other DBs ExplorEnz - The Enzyme Database: 2.7.1.50
IUBMB Enzyme Nomenclature: 2.7.1.50
ExPASy - ENZYME nomenclature database: 2.7.1.50
BRENDA, the Enzyme Database: 2.7.1.50
CAS: 9026-56-6
DBGET integrated database retrieval system