| Entry |
|
|---|
| Name |
fucokinase;
fucokinase (phosphorylating);
fucose kinase;
L-fucose kinase;
L-fucokinase;
ATP:6-deoxy-L-galactose 1-phosphotransferase;
ATP:L-fucose 1-phosphotransferase |
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
|---|
| Sysname |
ATP:beta-L-fucose 1-phosphotransferase |
|---|
| Reaction(IUBMB) |
ATP + L-fucose = ADP + beta-L-fucose 1-phosphate [RN:R03161] |
|---|
| Reaction(KEGG) |
R03161
 |
|---|
| Substrate |
ATP [CPD:C00002];
L-fucose [CPD:C01019] |
|---|
| Product |
ADP [CPD:C00008];
beta-L-fucose 1-phosphate [CPD:C02985] |
|---|
| Comment |
Requires a divalent cation for activity, with Mg2+ and Fe2+ giving
rise to the highest enzyme activity. Forms part of a salvage pathway
for reutilization of L-fucose. Can also phosphorylate D-arabinose,
but more slowly. |
|---|
| Pathway |
PATH: ec00051 Fructose and mannose metabolism
PATH: ec00520 Amino sugar and nucleotide sugar metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K05305 fucokinase |
|---|
| Genes |
HSA: 197258(FUK)
PTR: 468015(FUK)
MCC: 709226
MMU: 234730(Fuk)
RNO: 307848(Fuk)
CFA: 489715(FUK)
BTA: 519181(FUK)
ECB: 100054844(FUK)
OAA: 100075033
XLA: 100137687
DRE: 100005144
NVE: NEMVE_v1g168454
DDI: DDBDRAFT_0190464
TCR: 508379.10
LMA: LmjF16.0440 LmjF16.0480
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5646161]
Ishihara H, Massaro DJ, Heath EC.
The metabolism of L-fucose. 3. The enzymatic synthesis of
beta-L-fucose 1-phosphate.
J. Biol. Chem. 243 (1968) 1103-9.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:2986701]
Butler W, Serif GS.
Fucokinase, its anomeric specificity and mechanism of phosphate
group transfer.
Biochim. Biophys. Acta. 829 (1985) 238-43. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:9488699]
Park SH, Pastuszak I, Drake R, Elbein AD.
Purification to apparent homogeneity and properties of pig kidney
L-fucose kinase.
J. Biol. Chem. 273 (1998) 5685-91.
Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.52
IUBMB Enzyme Nomenclature: 2.7.1.52
ExPASy - ENZYME nomenclature database: 2.7.1.52
BRENDA, the Enzyme Database: 2.7.1.52
CAS: 37278-00-5 |
|---|
