| Entry |
|
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| Name |
1-phosphatidylinositol 4-kinase;
phosphatidylinositol kinase (phosphorylating);
phosphatidylinositol 4-kinase;
phosphatidylinositol kinase;
type II phosphatidylinositol kinase;
PI kinase;
PI 4-kinase |
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
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| Sysname |
ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase |
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| Reaction(IUBMB) |
ATP + 1-phosphatidyl-1D-myo-inositol = ADP +
1-phosphatidyl-1D-myo-inositol 4-phosphate [RN:R03361] |
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| Reaction(KEGG) |
R03361
 |
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| Substrate |
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol [CPD:C01194] |
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| Product |
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD:C01277] |
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| Comment |
This reaction is catalysed by at least two different isoforms. |
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| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec01100 Metabolic pathways
PATH: ec04070 Phosphatidylinositol signaling system |
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| Orthology |
KO: K00888 phosphatidylinositol 4-kinase |
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| Genes |
HSA: 5297(PI4KA) 5298(PI4KB)
PTR: 457291(PI4KB) 470256(PI4KA)
MCC: 698020(PI4KA) 710104(PI4KB)
MMU: 107650(Pi4kb) 224020(Pi4ka)
RNO: 64161(Pi4ka) 81747(Pi4kb)
CFA: 483196(PI4KB) 486443(PI4KA)
BTA: 282309(PI4KA) 286846(PI4KB)
SSC: 100156778 100157143
ECB: 100055429 100057017(PI4KA)
MDO: 100018085
GGA: 416767(PI4KA) 425661(PI4KB)
TGU: 100226976 100232416
XLA: 444446(pi4kb) 446720(pik4ca)
XTR: 100124755(pi4kb)
DRE: 406667(pi4k2a) 556956 563201(pi4kb) 564750
BFO: BRAFLDRAFT_92981
CIN: 100177020
SPU: 587444 590935
DME: Dmel_CG10260 Dmel_CG2929(Pi4KIIalpha) Dmel_CG7004(fwd)
DPO: Dpse_GA10199 Dpse_GA15526 Dpse_GA20022
DAN: Dana_GF22236 Dana_GF25052
DER: Dere_GG10961 Dere_GG12942 Dere_GG14670
DPE: Dper_GL16101 Dper_GL26893
DSE: Dsec_GM14285 Dsec_GM19234
DSI: Dsim_GD16613 Dsim_GD16614 Dsim_GD19607 Dsim_GD25715
DYA: Dyak_GE16267 Dyak_GE21031 Dyak_GE24164
DGR: Dgri_GH15747 Dgri_GH22280 Dgri_GH24853
DMO: Dmoj_GI14401 Dmoj_GI17272 Dmoj_GI24147
AGA: AgaP_AGAP007512 AgaP_AGAP010801
AAG: AaeL_AAEL000194 AaeL_AAEL009294
CQU: CpipJ_CPIJ000714 CpipJ_CPIJ019027
AME: 408373 551182
NVI: 100120357
TCA: 658290 661577
API: 100160263 100160544
ISC: IscW_ISCW015061
CEL: F35H12.4 Y75B8A.24
CBR: CBG08090
BMY: Bm1_32925 Bm1_45860
SMM: Smp_150660
NVE: NEMVE_v1g165173
HMG: 100200250 100204814
TAD: TRIADDRAFT_21411 TRIADDRAFT_55997
ATH: AT1G49340 AT5G64070
POP: POPTR_556445 POPTR_557279 POPTR_595372 POPTR_763998
RCU: RCOM_0937410 RCOM_1461660
VVI: 100250628 100265765
OSA: 4333883(Os03g0711200)
SBI: SORBI_01g010410(SORBIDRAFT_01g010410)
SORBI_05g009420(SORBIDRAFT_05g009420)
PPP: PHYPADRAFT_147576 PHYPADRAFT_235037
CRE: CHLREDRAFT_113185(PIK1) CHLREDRAFT_196944
OLU: OSTLU_40667
CME: CMI125C CMS267C
SCE: YLR305C(STT4) YNL267W(PIK1)
AGO: AGOS_ADL033W AGOS_AFR666C
KLA: KLLA0C02387g KLLA0C17292g
LTH: KLTH0D03608g KLTH0F02442g
DHA: DEHA0E11814g(DhPIK1)
PIC: PICST_49430(PIK1) PICST_79239(STT4)
PPA: PAS_chr1-3_0100 PAS_chr1-4_0380
VPO: Kpol_2000p63 Kpol_414p3
LEL: LELG_03301 LELG_03753
ZRO: ZYRO0F16610g ZYRO0G19888g
CAL: CaO19.10711(PIK1) CaO19.1814(STT4) CaO19.3199(PIK1)
CaO19.9377(STT4)
CTP: CTRG_03116 CTRG_05300 CTRG_06238
CDU: CD36_32670 CD36_51560
CGR: CAGL0D06446g CAGL0J08140g
YLI: YALI0B02376g YALI0E28153g
SPO: SPAC22E12.16c(pik1) SPBC577.06c
NCR: NCU09367 NCU10397
PAN: PODANSg2129 PODANSg4805
MGR: MGG_12862 MGG_13790
FGR: FG01161.1 FG05499.1
ANI: AN4278.2
AFM: AFUA_7G03760
AOR: AO090026000840
ANG: An13g00110
AFV: AFLA_131170
PCS: Pc20g09090
NFI: NFIA_024710
CIM: CIMG_07471
URE: UREG_07802
SSL: SS1G_09711 SS1G_12900
BFU: BC1G_08323 BC1G_11624
CNE: CNG00610 CNI02140
CNB: CNBG4170 CNBH2020
LBC: LACBIDRAFT_187897 LACBIDRAFT_290773
MPR: MPER_12855
UMA: UM04931.1 UM06103.1
MGL: MGL_3767 MGL_4095
ECU: ECU03_1100 ECU11_0450
MBR: MONBRDRAFT_169 MONBRDRAFT_34568
DDI: DDB_0191346(pikD) DDB_0232329 DDB_0238120
EHI: EHI_148700
EDI: EDI_333940
PFA: PFE0485w
PFD: PFDG_00292
PFH: PFHG_00935
PYO: PY04039
PCB: PC000459.02.0
PBE: PB001173.02.0 PB001191.02.0
PKN: PKH_102310
PVX: PVX_098050
TAN: TA05835 TA08175
TPV: TP01_0820 TP04_0387
BBO: BBOV_II002790 BBOV_IV009520
CPV: cgd8_4500
CHO: Chro.80518
TGO: TGME49_096010
TET: TTHERM_00157930 TTHERM_00219449 TTHERM_00323020 TTHERM_00389990
TTHERM_00554370 TTHERM_00951960 TTHERM_01008650
PTM: GSPATT00005667001 GSPATT00006568001 GSPATT00007965001
GSPATT00010804001 GSPATT00012877001 GSPATT00023634001
GSPATT00027213001 GSPATT00029485001 GSPATT00035938001
TBR: Tb927.3.4020 Tb927.4.1140
TCR: 508695.20 510003.30
LMA: LmjF29.1450 LmjF34.3590
LIF: LinJ29.1750 LinJ34.3110
LBZ: LbrM20_V2.3170 LbrM29_V2.1540
GLA: GL50803_16558
TVA: TVAG_161620 TVAG_236630
PTI: PHATRDRAFT_16364
TPS: THAPSDRAFT_262528 THAPSDRAFT_31223
 |
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| Structures |
PDB: 2JU0 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:4284712]
Colodzin M, Kennedy EP.
Biosynthesis of diphosphoinositide in brain.
J. Biol. Chem. 240 (1965) 3771-80.
Rattus norvegicus [GN:rno] |
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Reference
Authors
Title
Journal
Organism
|
2 [PMID:4290722]
Kai M, White GL, Hawthorne JN.
The phosphatidylinositol kinase of rat brain.
Biochem. J. 101 (1966) 328-37.
Rattus norvegicus [GN:rno] |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:2851325]
Walker DH, Dougherty N, Pike LJ.
Purification and characterization of a phosphatidylinositol kinase
from A431 cells.
Biochemistry. 27 (1988) 6504-11.
Homo sapiens [GN:hsa] |
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Reference
Authors
Title
Journal
|
4 [PMID:2833705]
Whitman M, Downes CP, Keeler M, Keller T, Cantley L.
Type I phosphatidylinositol kinase makes a novel inositol
phospholipid, phosphatidylinositol-3-phosphate.
Nature. 332 (1988) 644-6. |
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Reference
Authors
Title
Journal
Organism
|
5 [PMID:11244087]
Barylko B, Gerber SH, Binns DD, Grichine N, Khvotchev M, Sudhof TC,
Albanesi JP.
A novel family of phosphatidylinositol 4-kinases conserved from
yeast to humans.
J. Biol. Chem. 276 (2001) 7705-8.
Homo sapiens [GN:hsa], Saccharomyces cerevisiae [GN:sce] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.67
IUBMB Enzyme Nomenclature: 2.7.1.67
ExPASy - ENZYME nomenclature database: 2.7.1.67
BRENDA, the Enzyme Database: 2.7.1.67
CAS: 37205-54-2 |
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