| Entry |
|
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| Name |
1-phosphatidylinositol-4-phosphate 5-kinase;
diphosphoinositide kinase;
PIP kinase;
phosphatidylinositol 4-phosphate kinase;
phosphatidylinositol-4-phosphate 5-kinase;
type I PIP kinase |
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
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| Sysname |
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase |
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| Reaction(IUBMB) |
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP +
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [RN:R03469] |
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| Reaction(KEGG) |
R03469
 |
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| Substrate |
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD:C01277] |
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| Product |
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637] |
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| Comment |
This enzyme can also phosphorylate PtdIns3P in the 4-position, and
PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but
to a lesser extent. The last of these reactions occurs in vivo and
is physiologically relevant. Three different isoforms are known. |
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| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec01100 Metabolic pathways
PATH: ec04070 Phosphatidylinositol signaling system |
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| Orthology |
KO: K00889 1-phosphatidylinositol-4-phosphate 5-kinase |
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| Genes |
HSA: 200576(PIKFYVE) 23396(PIP5K1C) 8394(PIP5K1A) 8395(PIP5K1B)
8396(PIP4K2B)
PTR: 455590(PIP5K1C) 457288(PIP5K1A) 459908(PIKFYVE) 464513(PIP5K1B)
746830(PIP4K2B)
MCC: 695322 695366(PIP4K2B) 700538 710007(PIP5K1A) 710115
MMU: 100046931 108083(Pip4k2b) 18711(Pikfyve) 18717(Pip5k1c)
18719(Pip5k1b) 18720(Pip5k1a)
RNO: 309419(Pip5k1b) 314641(Pip5k1c) 316457(Pip5k3) 365865(Pip5k1a)
89812(Pip4k2b)
CFA: 475846(PIP5K1A) 476331(PIP5K1B) 478890(PIKFYVE) 485054(PIP5K1C)
491034(PIP4K2B)
BTA: 100125224(PIP5K1A) 504715 508819(PIP5K1C) 537654(PIP5K1B)
539211(PIP4K2B) 790873(PIKFYVE)
ECB: 100050520(PIP5K1B) 100055236(PIP4K2B) 100059655(PIP5K1A)
100066445
MDO: 100010549 100013564 100016918 100017950(PIP5K1A) 100021835
OAA: 100074263 100076756 100080469
GGA: 419999(PIP4K2B) 420072(PIP5K1C) 424114(PIP5K3)
427243(RCJMB04_20j15) 429983(PIP5K1A)
TGU: 100218810 100221379 100229363 100229771 100232143
XLA: 100036841 398687 399203(pip5k1c) 399394(pip5k2b) 444238
XTR: 100145583 448746(pip5k1b) 550069
DRE: 337690(pikfyve) 447840 449831(pip5k1b) 492549 553629(pip5k1a)
555708(pip5k1c)
BFO: BRAFLDRAFT_118352 BRAFLDRAFT_216408 BRAFLDRAFT_81009
CIN: 100179676 100187365 723796(ci-zf(fyve)-8)
SPU: 578946 579944 580595
DME: Dmel_CG17471 Dmel_CG3682(PIP5K59B) Dmel_CG6355(fab1)
Dmel_CG9985(sktl)
DPO: Dpse_GA19534 Dpse_GA22167 Dpse_GA25087
DAN: Dana_GF12741 Dana_GF13221 Dana_GF13551 Dana_GF23407
DER: Dere_GG16415 Dere_GG20828 Dere_GG21016 Dere_GG22810
DPE: Dper_GL10132 Dper_GL17272 Dper_GL17422 Dper_GL18405
DSE: Dsec_GM13005 Dsec_GM15773 Dsec_GM15967 Dsec_GM19947
DSI: Dsim_GD11719 Dsim_GD24357 Dsim_GD25249 Dsim_GD25438
DYA: Dyak_GE13767 Dyak_GE13959 Dyak_GE14244 Dyak_GE14484
DGR: Dgri_GH19848 Dgri_GH19882 Dgri_GH21799 Dgri_GH23952
DMO: Dmoj_GI14032 Dmoj_GI19831 Dmoj_GI20437 Dmoj_GI20548
AGA: AgaP_AGAP005216
AAG: AaeL_AAEL010238 AaeL_AAEL011274 AaeL_AAEL015255
CQU: CpipJ_CPIJ006826
AME: 409276 410183 724991
NVI: 100122133 100123047
TCA: 658852 663424
API: 100161846 100161889 100164484 100167842
ISC: IscW_ISCW003331 IscW_ISCW016474
CEL: F55A12.3(ppk-1) VF11C1L.1(ppk-3)
CBR: CBG12324 CBG16921
BMY: Bm1_33360 Bm1_33365 Bm1_36090
SMM: Smp_124970 Smp_142370.2 Smp_156680 Smp_156710
NVE: NEMVE_v1g105451 NEMVE_v1g146305 NEMVE_v1g201207 NEMVE_v1g237340
HMG: 100197010
TAD: TRIADDRAFT_19797 TRIADDRAFT_54491 TRIADDRAFT_54493
ATH: AT1G01460(PIPK11) AT1G10900 AT1G21980 AT1G60890 AT1G71010
AT1G77740 AT2G26420(PIP5K3) AT2G41210(PIP5K5) AT3G07960
AT3G14270 AT3G56960(PIP5K4) AT4G01190 AT4G33240
POP: POPTR_1078405 POPTR_178459 POPTR_410440 POPTR_548747
POPTR_555053 POPTR_582189 POPTR_766135 POPTR_777034
POPTR_837406
RCU: RCOM_0417950 RCOM_0502210 RCOM_0708740 RCOM_0842430
RCOM_1032640 RCOM_1320440 RCOM_1452400 RCOM_1617260
VVI: 100250604(GSVIVT00015324001) 100251489 100254952
100255527(GSVIVT00000653001) 100258261 100267980
OSA: 4332323(Os03g0262000) 4333051(Os03g0399500)
4333833(Os03g0701800) 4333853(Os03g0705300)
4340685(Os06g0259000) 4344166(Os07g0658700)
4345628(Os08g0428900) 4351470(Os12g0141100)
SBI: SORBI_01g010710(SORBIDRAFT_01g010710)
SORBI_01g010920(SORBIDRAFT_01g010920)
SORBI_01g033120(SORBIDRAFT_01g033120)
SORBI_01g040390(SORBIDRAFT_01g040390)
SORBI_02g041770(SORBIDRAFT_02g041770)
SORBI_05g002690(SORBIDRAFT_05g002690)
SORBI_07g020930(SORBIDRAFT_07g020930)
SORBI_07g022110(SORBIDRAFT_07g022110)
SORBI_10g009370(SORBIDRAFT_10g009370)
ZMA: 100193462(cl31817_1) 100216938
PPP: PHYPADRAFT_121474 PHYPADRAFT_210788 PHYPADRAFT_30361
PHYPADRAFT_40660
CRE: CHLREDRAFT_120269 CHLREDRAFT_195580
OLU: OSTLU_850
CME: CME153C CMN333C
SCE: YDR208W(MSS4)
AGO: AGOS_AGL096W
KLA: KLLA0A04301g
LTH: KLTH0F08008g
DHA: DEHA0F19448g
PIC: PICST_64487(MSS4)
PPA: PAS_chr1-1_0457
VPO: Kpol_1029p20 Kpol_1061p18
LEL: LELG_02070
ZRO: ZYRO0C04730g
CAL: CaO19.10663(MSS4) CaO19.3153(MSS4)
CTP: CTRG_02191
CDU: CD36_81060
CGR: CAGL0F05335g
YLI: YALI0F23573g
SPO: SPAC19G12.14(its3)
NCR: NCU02295
PAN: PODANSg1803
MGR: MGG_06572
FGR: FG10792.1
ANI: AN2766.2
AFM: AFUA_3G06080
AOR: AO090020000081
ANG: An11g10410
AFV: AFLA_103280
PCS: Pc20g07880
NFI: NFIA_071170
CIM: CIMG_00514
URE: UREG_00542
BFU: BC1G_16298
CNE: CNA03760
CNB: CNBA3560
LBC: LACBIDRAFT_392686 LACBIDRAFT_397690 LACBIDRAFT_397906
UMA: UM03809.1
MGL: MGL_0138
MBR: MONBRDRAFT_25486 MONBRDRAFT_32550
DDI: DDB_0185056(PIPkinA) DDB_0234212 DDB_0234213
EHI: EHI_153770
EDI: EDI_093870
PFA: MAL1P2.32
PFD: PFDG_01096
PFH: PFHG_00385
PYO: PY02398
PCB: PC000509.02.0
PBE: PB000893.02.0
PKN: PKH_020300
PVX: PVX_081270
TAN: TA11845
TPV: TP02_0200
BBO: BBOV_II007470
CPV: cgd8_3280
CHO: Chro.80381
TGO: TGME49_030490
TET: TTHERM_00047210 TTHERM_00471898 TTHERM_01125130 TTHERM_01457080
PTM: GSPATT00000655001 GSPATT00000714001 GSPATT00005572001
GSPATT00006938001 GSPATT00006945001 GSPATT00010139001
GSPATT00010565001 GSPATT00012283001 GSPATT00014456001
GSPATT00015691001 GSPATT00019649001 GSPATT00022539001
GSPATT00032331001 GSPATT00033281001
TBR: Tb927.4.1620
TCR: 504057.104 509715.120 510105.130 511001.70
LMA: LmjF34.3090
LIF: LinJ34.2700
LBZ: LbrM20_V2.2670
GLA: GL50803_11897
TVA: TVAG_462290
PTI: PHATRDRAFT_49524
TPS: THAPSDRAFT_18434 THAPSDRAFT_264335 THAPSDRAFT_270069
 |
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| Structures |
PDB: 1BO1 2GK9 3H1Z 3H85 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:4295336]
Kai M, Salway JG, Hawthorne JN.
The diphosphoinositide kinase of rat brain.
Biochem. J. 106 (1968) 791-801.
Rattus norvegicus [GN:rno] |
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Reference
Authors
Title
Journal
|
2
Kai, M., Salway, J.G., Michell, R.H. and Hawthorne, J.N.
The biosynthesis of triphosphoinositide by rat brain in vitro.
Biochem. Biophys. Res. Commun. 22 (1966) 370-375. |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:9367159]
Rameh LE, Tolias KF, Duckworth BC, Cantley LC.
A new pathway for synthesis of
phosphatidylinositol-4,5-bisphosphate.
Nature. 390 (1997) 192-6.
mammalian |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.68
IUBMB Enzyme Nomenclature: 2.7.1.68
ExPASy - ENZYME nomenclature database: 2.7.1.68
BRENDA, the Enzyme Database: 2.7.1.68
CAS: 104645-76-3 |
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