KEGG   ENZYME: 2.7.1.74Help
Entry
EC 2.7.1.74                 Enzyme                                 

Name deoxycytidine kinase;
deoxycytidine kinase (phosphorylating);
2'-deoxycytidine kinase;
Ara-C kinase;
arabinofuranosylcytosine kinase;
deoxycytidine-cytidine kinase
Class Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname NTP:deoxycytidine 5'-phosphotransferase
Reaction(IUBMB) NTP + deoxycytidine = NDP + dCMP [RN:R02321]
Reaction(KEGG) R02321 > R01666;
(other) R00185
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Substrate NTP [CPD:C00201];
deoxycytidine [CPD:C00881]
Product NDP [CPD:C00454];
dCMP [CPD:C00239]
Comment Cytosine arabinoside can act as acceptor; all natural nucleoside
triphosphates (except dCTP) can act as donors.
Pathway PATH: ec00230  Purine metabolism
PATH: ec00240  Pyrimidine metabolism
Orthology KO: K00893  deoxycitidine kinase
Genes HSA: 1633(DCK)
PTR: 461273(DCK)
MCC: 705040(DCK)
MMU: 13178(Dck)
RNO: 79127(Dck)
CFA: 482188(DCK)
BTA: 530642(DCK)
ECB: 100054704
MDO: 100014536
OAA: 100078818
GGA: 422648(DCK)
TGU: 100223331
XLA: 494987
XTR: 594934(dck)
DRE: 474325(dck) 541538
OSA: 4338875(Os05g0430200)
BGA: BG0242(dck)
Taxonomy
Structures PDB: 1P5Z  1P60  1P61  1P62  2A2Z  2A30  2A7Q  2NO0  2NO1  2NO6  
     2NO7  2NO9  2NOA  2QRN  2QRO  2ZI3  2ZI4  2ZI5  2ZI6  2ZI7  
     2ZI9  2ZIA  3HP1  
Reference
  Authors
  Title

  Journal
  Organism
1  [PMID:5442271]
Durham JP, Ives DH.
Deoxycytidine kinase. II. Purification and general properties of the
calf thymus enzyme.
J. Biol. Chem. 245 (1970) 2276-84.
Bos taurus [GN:bta]
Reference
  Authors
  Title

  Journal
  Organism
2  [PMID:5462538]
Ives DH, Durham JP.
Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the
calf thymus enzyme.
J. Biol. Chem. 245 (1970) 2285-94.
Bos taurus [GN:bta]
Reference
  Authors
  Title

  Journal
  Organism
3  [PMID:5687717]
Kessel D.
Properties of deoxycytidine kinase partially purified from L1210
cells.
J. Biol. Chem. 243 (1968) 4739-44.
Bos taurus [GN:bta]
Reference
  Authors
  Title


  Journal
  Organism
4  [PMID:5684726]
Momparler RL, Fischer GA.
Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase:
purification, properties, and kinetic studies with cytosine
arabinoside.
J. Biol. Chem. 243 (1968) 4298-304.
Bos taurus [GN:bta]
Other DBs ExplorEnz - The Enzyme Database: 2.7.1.74
IUBMB Enzyme Nomenclature: 2.7.1.74
ExPASy - ENZYME nomenclature database: 2.7.1.74
BRENDA, the Enzyme Database: 2.7.1.74
CAS: 9039-45-6

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