| Entry |
|
|---|
| Name |
deoxycytidine kinase;
deoxycytidine kinase (phosphorylating);
2'-deoxycytidine kinase;
Ara-C kinase;
arabinofuranosylcytosine kinase;
deoxycytidine-cytidine kinase |
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
|---|
| Sysname |
NTP:deoxycytidine 5'-phosphotransferase |
|---|
| Reaction(IUBMB) |
NTP + deoxycytidine = NDP + dCMP [RN:R02321] |
|---|
| Reaction(KEGG) |
R02321 > R01666;
(other) R00185
 |
|---|
| Substrate |
NTP [CPD:C00201];
deoxycytidine [CPD:C00881] |
|---|
| Product |
NDP [CPD:C00454];
dCMP [CPD:C00239] |
|---|
| Comment |
Cytosine arabinoside can act as acceptor; all natural nucleoside
triphosphates (except dCTP) can act as donors. |
|---|
| Pathway |
PATH: ec00230 Purine metabolism
PATH: ec00240 Pyrimidine metabolism |
|---|
| Orthology |
KO: K00893 deoxycitidine kinase |
|---|
| Genes |
HSA: 1633(DCK)
PTR: 461273(DCK)
MCC: 705040(DCK)
MMU: 13178(Dck)
RNO: 79127(Dck)
CFA: 482188(DCK)
BTA: 530642(DCK)
ECB: 100054704
MDO: 100014536
OAA: 100078818
GGA: 422648(DCK)
TGU: 100223331
XLA: 494987
XTR: 594934(dck)
DRE: 474325(dck) 541538
OSA: 4338875(Os05g0430200)
BGA: BG0242(dck)
 |
|---|
| Structures |
PDB: 1P5Z 1P60 1P61 1P62 2A2Z 2A30 2A7Q 2NO0 2NO1 2NO6
2NO7 2NO9 2NOA 2QRN 2QRO 2ZI3 2ZI4 2ZI5 2ZI6 2ZI7
2ZI9 2ZIA 3HP1 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5442271]
Durham JP, Ives DH.
Deoxycytidine kinase. II. Purification and general properties of the
calf thymus enzyme.
J. Biol. Chem. 245 (1970) 2276-84.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5462538]
Ives DH, Durham JP.
Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the
calf thymus enzyme.
J. Biol. Chem. 245 (1970) 2285-94.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5687717]
Kessel D.
Properties of deoxycytidine kinase partially purified from L1210
cells.
J. Biol. Chem. 243 (1968) 4739-44.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:5684726]
Momparler RL, Fischer GA.
Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase:
purification, properties, and kinetic studies with cytosine
arabinoside.
J. Biol. Chem. 243 (1968) 4298-304.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.74
IUBMB Enzyme Nomenclature: 2.7.1.74
ExPASy - ENZYME nomenclature database: 2.7.1.74
BRENDA, the Enzyme Database: 2.7.1.74
CAS: 9039-45-6 |
|---|
