KEGG   ENZYME: 2.7.1.95Help
Entry
EC 2.7.1.95                 Enzyme                                 
Name
kanamycin kinase;
neomycin-kanamycin phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:kanamycin 3'-O-phosphotransferase
Reaction(IUBMB)
ATP + kanamycin = ADP + kanamycin 3'-phosphate
Reaction(KEGG)
(other) R01888
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Substrate
ATP [CPD:C00002];
kanamycin [CPD:C00304]
Product
ADP [CPD:C00008];
kanamycin 3'-phosphate [CPD:C03281]
Comment
Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin.
Orthology
K00897  
aminoglycoside 3'-phosphotransferase
Genes
BMY: 
EHI: 
EBW: 
EOJ: 
EOI: 
ECM: 
SEC: 
SC026(aph)
KPN: 
KOX: 
PMP: 
Pmu_02740(aphA1)
GAN: 
UMN179_01162
SML: 
Smlt2120
SMT: 
Smal_1717
PAE: 
PA4119(aph)
PAU: 
PA14_10670(aph)
PAP: 
PSPA7_0973(aph) PSPA7_3721
PAG: 
PLES_08521(aph)
ABY: 
ABAYE3578
ABN: 
AB57_0288
ABZ: 
ABZJ_p00004
ABD: 
ABTW07_3876(aphA1b)
REH: 
H16_B1333
BUR: 
Bcep18194_B2197
BCJ: 
BCAM0928(neo)
MLO: 
mlr2696
SME: 
SMc03094
SMK: 
Sinme_3053
SMQ: 
SinmeB_2827
SMX: 
SM11_chr3177
ARA: 
Arad_3116
RET: 
RHE_CH02947
REC: 
RHECIAT_CH0003111
RLE: 
RL3397(neo)
RLT: 
Rleg2_2693
RLG: 
Rleg_2951
OAN: 
Oant_1320
RPT: 
Rpal_0195
RCE: 
RC1_0237(butA)
BCZ: 
BCZK1266(aph) BCZK1900(aph)
BTK: 
BT9727_1264(aph)
SAX: 
pUSA300HOUMR0018
SUZ: 
MS7_0063(aphA)
SUW: 
SATW20_20760(aphA)
SER: 
SEA0010(aphA)
SDT: 
SPSE_1794(aphA)
GYM: 
GYMC10_0161
LLA: 
L33782(ymdC)
LLK: 
LLKF_1253(ymdC)
LLC: 
LACR_1330
LLM: 
llmg_1293
SPW: 
SPCG_1325 SPCG_1876
SPP: 
SPP_1930
SSA: 
SSA_1830
SUI: 
SSUJS14_0692
SGO: 
SGO_0628(ymdC)
SEQ: 
SZO_03450
SEZ: 
Sez_1628
SEU: 
SEQ_1846
SMB: 
smi_1708(aphA)
STD: 
SPPN_09665
LJO: 
LJ1688
LJF: 
FI9785_1471(aph)
LAC: 
LBA1348
LGA: 
LGAS_1458
EFU: 
HMPREF0351_12797(aphA)
BPB: 
bpr_I2232
RHO: 
RHOM_01605
MTU: 
Rv3817
MTC: 
MT3925.1(aph)
MRA: 
MRA_3857(aph)
MTF: 
TBFG_13851
MTB: 
TBMG_03864
MBO: 
Mb3847
MBB: 
BCG_3879
MBT: 
JTY_3881
MUL: 
MUL_5000
MAB: 
MAB_0163c
MMI: 
MMAR_5380
CUR: 
cur_1535(aph(3')-Ia)
NFA: 
nfa38480
TPR: 
Tpau_1464
MTS: 
MTES_1899
AAI: 
AARI_03100
KRH: 
KRH_10490
CFL: 
Cfla_1184
KFL: 
Kfla_1280
NDA: 
Ndas_3531
SRO: 
Sros_0454 Sros_5038
FRA: 
Francci3_3368
KRA: 
Krad_1799
CAI: 
Caci_6179
BBI: 
BBIF_1747
BBP: 
BBPR_1808
STR: 
Sterm_0369
CAU: 
Caur_2511
CHL: 
Chy400_2709
DRA: 
DR_0066
DGE: 
Dgeo_2256
DDR: 
Deide_21650
MSV: 
Mesil_0966
 » show all
Taxonomy
Reference
1  [PMID:4970990]
  Authors
Doi O, Ogura M, Tanaka N, Umezawa H.
  Title
Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa.
  Journal
Appl. Microbiol. 16 (1968) 1276-81.
  Organism
Pseudomonas aeruginoa
Reference
2  [PMID:13416259]
  Authors
DOLIN MI.
  Title
The Streptococcus faecalis oxidases for reduced diphosphopyridine nucleotide.  III.  Isolation and properties of a flavin peroxidase for reduced diphosphopyridine nucleotide.
  Journal
J. Biol. Chem. 225 (1957) 557-73.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62213-36-9
DBGET integrated database retrieval system