KEGG   ENZYME: 2.7.11.10Help
Entry
EC 2.7.11.10                Enzyme                                 

Name
IkappaB kinase;
CHUK;
IKBKA;
IKBKB;
IKK;
IKK-1;
IKK-2;
inhibitor of NFkappaB kinase;
inhibitor of NF-kappaB kinase;
STK12;
TANK-binding kinase 1;
TBK1
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[IkappaB protein] phosphotransferase
Reaction(IUBMB)
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]
Reaction(KEGG)
(other) R00162
Show
Substrate
ATP [CPD:C00002];
[IkappaB protein]
Product
ADP [CPD:C00008];
[IkappaB phosphoprotein]
Comment
The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
History
EC 2.7.11.10 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04467  
inhibitor of nuclear factor kappa-B kinase subunit alpha
K05410  
TANK-binding kinase 1
K07209  
inhibitor of nuclear factor kappa-B kinase subunit beta
K07211  
inhibitor of nuclear factor kappa-B kinase subunit epsilon
Genes
HSA: 
1147(CHUK) 29110(TBK1) 3551(IKBKB) 9641(IKBKE)
PTR: 
450673(CHUK) 452047(TBK1) 472749(IKBKB) 742813(IKBKE)
PPS: 
100989390(IKBKB) 100990211(TBK1) 100992569(IKBKE) 100995228(CHUK)
GGO: 
101125384(IKBKE) 101137405(CHUK) 101138038(TBK1) 101141659(IKBKB)
PON: 
100174735(CHUK) 100433568(TBK1) 100440586(IKBKB) 100448480(IKBKE)
NLE: 
100582856(TBK1) 100588081(IKBKB) 100596225(CHUK) 100605137(IKBKE)
MCC: 
695607(IKBKE) 704683(IKBKB) 709511(CHUK) 717427(TBK1)
MCF: 
102115964(CHUK) 102126428(IKBKE) 102144774(TBK1) 102146604(IKBKB)
CJC: 
100392518(IKBKE) 100393096(IKBKB) 100399701(TBK1) 100410737(CHUK)
MMU: 
12675(Chuk) 16150(Ikbkb) 56480(Tbk1) 56489(Ikbke)
RNO: 
299827(Tbk1) 309361(Chuk) 363984(Ikbke) 84351(Ikbkb)
CGE: 
NGI: 
103725939(Ikbke) 103726621(Ikbkb) 103730726(Tbk1) 103743976(Chuk)
HGL: 
101697947(Ikbke) 101711077(Ikbkb) 101713766(Tbk1) 101719306(Chuk)
OCU: 
100354455(IKBKE) 100355888(CHUK) 100356401(IKBKB) 100358771(TBK1)
TUP: 
102467954(IKBKB) 102481203(IKBKE) 102484078(TBK1) 102501308(CHUK)
CFA: 
477796(CHUK) 478950(IKBKE) 481145(TBK1) 482839(IKBKB)
AML: 
UMR: 
103656833(TBK1) 103658916(CHUK) 103671004(IKBKE) 103677059(IKBKB)
FCA: 
100142682(IKBKB) 101086282(IKBKE) 101091955(TBK1) 101095617(CHUK)
PTG: 
102949289(CHUK) 102960158(TBK1) 102963614(IKBKE) 102963734(IKBKB)
BTA: 
281073(CHUK) 281854(IKBKB) 533141(TBK1) 533216(IKBKE)
BOM: 
102271506(IKBKE) 102279479(TBK1) 102281443(IKBKB) 102281886(CHUK)
PHD: 
102330768(IKBKE) 102332461(CHUK) 102337166(IKBKB) 102341504(TBK1)
CHX: 
102177406(IKBKB) 102181262(CHUK) 102181474(TBK1) 102183809(IKBKE)
OAS: 
101110830(TBK1) 101111143(CHUK) 101116923(IKBKE) 780484(IKKBETA)
SSC: 
100101471(IKBKB) 100125828(TBK1) 100135662(CHUK) 100519508(IKBKE)
CFR: 
102503497(CHUK) 102508142(IKBKB) 102514948(TBK1) 102519234(IKBKE)
BACU: 
103013353(TBK1) 103013616(IKBKE) 103015119(IKBKB) 103015414(CHUK)
LVE: 
103080924(IKBKE) 103081814(TBK1) 103085220(CHUK) 103088633(IKBKB)
ECB: 
100050167(IKBKB) 100051650(TBK1) 100055384(IKBKE) 100070393(CHUK)
MYB: 
102241250(TBK1) 102248515(IKBKE) 102261405(IKBKB) 102261467(CHUK)
MYD: 
102760291(IKBKE) 102760888(CHUK) 102769631(TBK1) 102773824(IKBKB)
PALE: 
102878859(TBK1) 102879469(CHUK) 102889768(IKBKE) 102893261(IKBKB)
MDO: 
100019578(IKBKE) 100027952(CHUK) 100033031(IKBKB)
SHR: 
100913624(CHUK) 100915362(TBK1) 100928932(IKBKB) 100934784(IKBKE)
OAA: 
100076520(TBK1) 100077063(IKBKE) 100078925(IKBKB) 100082351(CHUK)
GGA: 
417825(TBK1) 423669(CHUK) 426792(IKBKB) 430480(IKBKE)
MGP: 
APLA: 
101790255(IKBKB) 101800085(TBK1) 101800153(IKBKE) 101801064(CHUK)
TGU: 
100221281(CHUK) 100224042 100225072(IKBKB) 100225715(TBK1) 100228860(IKBKE)
FAB: 
101809300(TBK1) 101809821(IKBKB) 101812706(CHUK) 101814828(IKBKE)
PHI: 
102100562(IKBKB) 102105384(IKBKE) 102107801(CHUK) 102112102(TBK1)
FPG: 
101911068(TBK1) 101911668(IKBKE) 101914413(CHUK) 101922064(IKBKB)
FCH: 
102050482(IKBKE) 102051211(TBK1) 102053491(CHUK) 102058892(IKBKB)
CLV: 
102084658(CHUK) 102085310(TBK1) 102087238(IKBKB) 102088357(IKBKE)
ASN: 
102372815(IKBKE) 102374729(CHUK) 102377560(IKBKB) 102383892(TBK1)
AMJ: 
102560016(TBK1) 102561191(IKBKB) 102561936(CHUK) 102568699(IKBKE)
PSS: 
102454064(CHUK) 102454676(IKBKB) 102457979(TBK1) 102464043(IKBKE)
CMY: 
102930512(IKBKE) 102932073(IKBKB) 102932800(CHUK) 102938424(TBK1)
ACS: 
100551699(ikbkb) 100553575(tbk1) 100562496(ikbke) 100565922(chuk)
PBI: 
XLA: 
432200(ikbkb) 444556(chuk) 446351(tbk1) 734896(ikbke)
XTR: 
100216212(tbk1) 100487744(ikbke) 448125(ikbkb) 549654(chuk)
DRE: 
393287(chuk) 437024(ikbke) 563560(ikbkb) 692289(tbk1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
778650(ikk-epsilon) 778921(ikk-alpha/beta) 780713(ikk-epsilon)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
413493(ik2)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
HRO: 
LGI: 
NVE: 
HMG: 
TAD: 
AQU: 
 » show all
Taxonomy
Reference
1  [PMID:9244310]
  Authors
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M.
  Title
Identification and characterization of an IkappaB kinase.
  Journal
Cell. 90 (1997) 373-83.
  Sequence
[hsa:1147]
Reference
2  [PMID:9346484]
  Authors
Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A.
  Title
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
  Journal
Science. 278 (1997) 860-6.
  Sequence
[hsa:1147 3551]
Reference
3  [PMID:9346241]
  Authors
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M.
  Title
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
  Journal
Cell. 91 (1997) 243-52.
Reference
4  [PMID:15653325]
  Authors
Viatour P, Merville MP, Bours V, Chariot A.
  Title
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation.
  Journal
Trends. Biochem. Sci. 30 (2005) 43-52.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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