KEGG   ENZYME: 2.7.11.11Help
Entry
EC 2.7.11.11                Enzyme                                 
Name
cAMP-dependent protein kinase;
PKA;
PKA C;
protein kinase A;
STK22
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (cAMP-dependent)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
cAMP is required to activate this enzyme. The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits [i.e. R2C2 + 4 cAMP = R2(cAMP)4 + 2 C].
Orthology
K04345  
protein kinase A
K07198  
5'-AMP-activated protein kinase, catalytic alpha subunit
Genes
HSA: 
5562(PRKAA1) 5563(PRKAA2) 5566(PRKACA) 5567(PRKACB) 5568(PRKACG) 5613(PRKX)
PTR: 
449495(PRKX) 455776(PRKACA) 469367(PRKACB) 471564(PRKAA1) 472944(PRKACG) 741802(PRKAA2) 751063
PPS: 
100968237(PRKACA) 100970917(PRKACB) 100975618(PRKAA1) 100982589(PRKACG) 100991417(PRKAA2) 100993844
GGO: 
101133255 101133536(PRKACA) 101134260(PRKACB) 101137882(PRKAA2) 101151469(PRKACG) 101152987(PRKAA1)
PON: 
100172060(PRKAA2) 100174304(PRKAA1) 100174748(PRKACB) 100431906(PRKACG) 100434648
MCC: 
100270699(PRKX) 695558(PRKAA1) 709728(PRKACB) 717703(PRKAA2) 718632(PRKACA)
MMU: 
105787(Prkaa1) 108079(Prkaa2) 18747(Prkaca) 18749(Prkacb) 19108(Prkx)
RNO: 
25636(Prkaca) 293508(Prkacb) 501563(Prkx) 65248(Prkaa1) 78975(Prkaa2)
CFA: 
403556(PRKACA) 479351(PRKAA1) 479975(PRKACB) 489571(PRKAA2) 610031(PRKX)
AML: 
FCA: 
101081957(PRKX) 101090494(PRKACA) 101095353(PRKACB) 101095885(PRKAA1) 101096000(PRKAA2)
BTA: 
282322(PRKACA) 282323(PRKACB) 505773(PRKX) 538954(PRKAA2) 540404(PRKAA1)
SSC: 
100145903(PRKAA1) 100520353 397504(PRKAA2) 397652(PRKACA)
ECB: 
100009710(PRKAA1) 100034159(PRKAA2) 100052828 100064302(PRKACA) 100064903
MDO: 
100009830 100011211 100013711(PRKAA1) 100019066(PRKAA2) 100026861 100032298
SHR: 
100915481(PRKACA) 100926139(PRKAA2) 100928944(PRKAA1) 100928966(PRKX) 100934183(PRKACB)
OAA: 
100075352(PRKAA1) 100078846 100083943 100088079
GGA: 
418656(PRKX) 424542(PRKACB) 427185(PRKAA1) 429110(PRKAA2)
MGP: 
100034740(PRKAA1) 100545867 100548554 780945(PRKAA2)
TGU: 
100217569(PRKAA1) 100224153(PRKAA2) 100226105(PRKACB) 100227397 100227619(PRKX)
ACS: 
100551935(prkaa2) 100558272 100559138 100567445(prkaa1)
XLA: 
100101276(prkaca) 380388(prkacb) 399172(prkaa2) 446502(prkacbb) 495290(prkaa1)
XTR: 
100038053(prkacb) 100145520(prkaa1) 100216099(prkaa2) 100494406 549157(prkaca)
DRE: 
100001198(prkaa1) 100538234(prkacb) 393998(prkacba) 445076(prkacab) 561941 563147(prkacbb) 564064(prkacaa) 572074(prkaa2)
TRU: 
101062935 101065197 101066292 101067856 101069822 101075373 101076074
OLA: 
101162057 101163742 101168847 101170876 101173851
BFO: 
BRAFLDRAFT_132295 BRAFLDRAFT_239705
CIN: 
100175976 100176009 100184788
SPU: 
100888004 583938 589947
DME: 
Dmel_CG12066(Pka-C2) Dmel_CG3051(SNF1A) Dmel_CG4379(Pka-C1) Dmel_CG6117(Pka-C3)
DPO: 
Dpse_GA11370 Dpse_GA11372 Dpse_GA15892 Dpse_GA18145 Dpse_GA23555
DAN: 
Dana_GF10368 Dana_GF21013 Dana_GF21892 Dana_GF23314 Dana_GF23315
DER: 
Dere_GG11916 Dere_GG11917 Dere_GG12850 Dere_GG13511 Dere_GG24016
DPE: 
Dper_GL13992 Dper_GL13993 Dper_GL14247 Dper_GL19216 Dper_GL24922
DSE: 
Dsec_GM12137 Dsec_GM12138 Dsec_GM12352 Dsec_GM19132
DSI: 
Dsim_GD12529 Dsim_GD16554 Dsim_GD16880 Dsim_GD16891 Dsim_GD22345
DWI: 
Dwil_GK13113 Dwil_GK13114 Dwil_GK15458 Dwil_GK16296 Dwil_GK20594
DYA: 
Dyak_GE10413(Dyak_Pka-C1) Dyak_GE16684 Dyak_GE19804 Dyak_GE23130 Dyak_GE23365 Dyak_GE23367
DGR: 
Dgri_GH11053 Dgri_GH12117 Dgri_GH14103 Dgri_GH14104 Dgri_GH17207
DMO: 
Dmoj_GI10635 Dmoj_GI10636 Dmoj_GI11297 Dmoj_GI16329 Dmoj_GI17571
DVI: 
Dvir_GJ15670 Dvir_GJ17913 Dvir_GJ22991 Dvir_GJ22992
AGA: 
AgaP_AGAP001384 AgaP_AGAP002686 AgaP_AGAP008039 AgaP_AGAP011840
AAG: 
AaeL_AAEL001976 AaeL_AAEL007153 AaeL_AAEL007293 AaeL_AAEL011837
CQU: 
CpipJ_CPIJ002636 CpipJ_CPIJ002898 CpipJ_CPIJ018257
AME: 
409577(SNF1A) 409791(Pka-C1) 410228(Pka-C3)
NVI: 
100119822(NV15281) 100120450(NV13517) 100328539(Pka-C1)
TCA: 
656552(Pka-C1) 661839 663357(Snf1a)
API: 
100159120 100161173 100163418
PHU: 
Phum_PHUM029040 Phum_PHUM090820 Phum_PHUM318270
ISC: 
IscW_ISCW013988 IscW_ISCW020637
CEL: 
CELE_F47F2.1(F47F2.1) CELE_T01C8.1(aak-2) CELE_ZK909.2(kin-1)
CBR: 
CBG14305 CBG16249(Cbr-aak-2) CBG19814(Cbr-kin-1)
BMY: 
Bm1_11790 Bm1_50100
TSP: 
Tsp_03463 Tsp_09176
SMM: 
Smp_142990 Smp_152330 Smp_194610
NVE: 
NEMVE_v1g171208 NEMVE_v1g230515
HMG: 
100198292(prkaca)
TAD: 
TRIADDRAFT_37919
AQU: 
100640804 100641589 100642122
ATH: 
AT2G20050 AT3G01090(KIN10) AT3G29160(KIN11)
ALY: 
ARALYDRAFT_317081 ARALYDRAFT_480465 ARALYDRAFT_484683
GMX: 
100796687 100806916 547544
MTR: 
MTR_4g066710 MTR_6g012990
CSV: 
101207183 101211720
RCU: 
RCOM_0538120
POP: 
POPTR_818055
VVI: 
100254223
OSA: 
4332495 4339410 4345873
DOSA: 
Os03t0289100-02(Os03g0289100) Os05t0530500-02(Os05g0530500) Os08t0484600-01(Os08g0484600)
BDI: 
100832804 100836644 100839912
SBI: 
SORBI_03g033530(SORBIDRAFT_03g033530) SORBI_09g026450(SORBIDRAFT_09g026450)
ZMA: 
100192108 100279221 542687(SnrK1)
SMO: 
SELMODRAFT_110120 SELMODRAFT_234034 SELMODRAFT_450118(SnRK1.2-2)
PPP: 
PHYPADRAFT_126373 PHYPADRAFT_228849(snf1a) PHYPADRAFT_228852(snf1b)
CRE: 
CHLREDRAFT_106184 CHLREDRAFT_121355
VCN: 
VOLCADRAFT_81085 VOLCADRAFT_98607
OLU: 
OSTLU_12650
OTA: 
Ot06g03970
CME: 
CMF139C
SCE: 
YJL164C(TPK1) YKL166C(TPK3) YPL203W(TPK2)
AGO: 
AGOS_AEL115C AGOS_AFL090W
ERC: 
Ecym_2203 Ecym_8095
KLA: 
KLLA0B07205g KLLA0D03190g
LTH: 
KLTH0F04840g KLTH0H04180g
PPA: 
PAS_chr1-4_0357 PAS_chr3_0964
VPO: 
Kpol_1033p50 Kpol_2002p75
ZRO: 
ZYRO0G08844g ZYRO0G18502g
CGR: 
CAGL0G09020g CAGL0M08404g
NCS: 
NCAS_0A01100(NCAS0A01100) NCAS_0I02840(NCAS0I02840)
NDI: 
NDAI_0A00960(NDAI0A00960) NDAI_0B00210(NDAI0B00210) NDAI_0F01650(NDAI0F01650)
TPF: 
TPHA_0E02840(TPHA0E02840) TPHA_0E03300(TPHA0E03300)
TBL: 
TBLA_0A02030(TBLA0A02030) TBLA_0C05830(TBLA0C05830)
TDL: 
TDEL_0C03710(TDEL0C03710) TDEL_0E05220(TDEL0E05220)
KAF: 
KAFR_0F01800(KAFR0F01800) KAFR_0G00480(KAFR0G00480) KAFR_0K00330(KAFR0K00330)
DHA: 
DEHA2B12386g DEHA2F23782g
PIC: 
PICST_68202(TPK2) PICST_70266
PGU: 
PGUG_00446 PGUG_01778
LEL: 
LELG_00555 LELG_02456
CAL: 
CaO19.12357(TPK3) CaO19.2277(TPK2) CaO19.4892(TPK3) CaO19.9817(TPK2)
CTP: 
CTRG_01736 CTRG_03315
CDU: 
CD36_09610 CD36_21480(CaTPK2)
COT: 
CORT_0A04970 CORT_0C05890
YLI: 
YALI0C08305g
CLU: 
CLUG_00572 CLUG_05816
NCR: 
NCU06240
SMP: 
SMAC_01361 SMAC_07080
PAN: 
PODANSg4388
TTT: 
THITE_2112048 THITE_2119633
MTM: 
MYCTH_2297709 MYCTH_2304075
MGR: 
MGG_06368
FGR: 
FG07251.1 FG08729.1
NHE: 
NECHADRAFT_59012 NECHADRAFT_68629
VAL: 
VDBG_02174 VDBG_08817
SSL: 
SS1G_03171 SS1G_13577
BFU: 
BC1G_07542 BC1G_10410
ANI: 
AN6305.2
NFI: 
NFIA_078710 NFIA_087380
AFM: 
AFUA_2G12200
AOR: 
AOR_1_360094(AO090120000207) AOR_1_786014(AO090026000426)
AFV: 
AFLA_091910 AFLA_135040
ACT: 
ACLA_011960 ACLA_071080
PCS: 
Pc20g14470 Pc22g16500
CIM: 
CIMG_05383 CIMG_06775
CPW: 
CPC735_032030 CPC735_065510
PBL: 
PAAG_00108 PAAG_04050
URE: 
UREG_03689 UREG_06328
ABE: 
ARB_00580 ARB_06644
TVE: 
TRV_02144 TRV_02424
AJE: 
HCAG_00714 HCAG_03889
PNO: 
SNOG_09577 SNOG_13001
PTE: 
PTT_11769 PTT_12790
ZTR: 
MYCGRDRAFT_38697(MgTpk1) MYCGRDRAFT_99725(Tpk2)
TML: 
GSTUM_00000085001 GSTUM_00000447001
SPO: 
SPBC106.10(pka1)
CNE: 
CNA03840 CNI02980
CNB: 
CNBA3650 CNBH2850
CGI: 
CGB_A3580C CGB_H5240W
PPL: 
POSPLDRAFT_112798 POSPLDRAFT_44442
LBC: 
LACBIDRAFT_189547 LACBIDRAFT_255253
CCI: 
CC1G_04466 CC1G_05183
SCM: 
SCHCODRAFT_16601(pkac2) SCHCODRAFT_65574(pkac1)
UMA: 
UM01124.1 UM04456.1
MGL: 
MGL_3248
PGR: 
PGTG_17146
ECU: 
ECU07_0520
EIN: 
Eint_070460
EHE: 
EHEL_070490
NCE: 
NCER_101539
MBR: 
MONBRDRAFT_12960 MONBRDRAFT_30993 MONBRDRAFT_31027
NGR: 
NAEGRDRAFT_31357 NAEGRDRAFT_33859
DDI: 
DDB_G0283907(pkaC)
DPP: 
DICPUDRAFT_42383(PKAC) DICPUDRAFT_58802
EHI: 
EHI_053040(4.t00093)
PFA: 
PFI1685w(PfPKAc)
PFD: 
PFDG_02360
PFH: 
PFHG_02233
PYO: 
PY05235
PCB: 
PC000802.04.0
PBE: 
PB000532.02.0
PKN: 
PKH_073290
PVX: 
PVX_086975
PCY: 
PCYB_074210
TAN: 
TA12860 TA14790
TPV: 
TP02_0378 TP02_0727 TP04_0818
BBO: 
BBOV_I004190(19.m02221) BBOV_III005740(17.m07511) BBOV_III009120(17.m07797)
CPV: 
cgd3_3040
CHO: 
Chro.30344
TGO: 
TGME49_026030 TGME49_028420 TGME49_033900 TGME49_086470
TET: 
TTHERM_00433420 TTHERM_00433560 TTHERM_00658860 TTHERM_00992710 TTHERM_01017250 TTHERM_01020820
PTM: 
GSPATT00000190001 GSPATT00000950001 GSPATT00007679001 GSPATT00008150001 GSPATT00008764001 GSPATT00010342001 GSPATT00011825001 GSPATT00012047001 GSPATT00015043001 GSPATT00019371001 GSPATT00021511001 GSPATT00021701001 GSPATT00029731001 GSPATT00030705001 GSPATT00031782001 PTMB.308
TBR: 
Tb09.211.2360 Tb09.211.2410 Tb10.389.0490
TCR: 
508461.310 510329.210 511269.50
LMA: 
LMJF_18_1080(PKAC1) LMJF_29_2020
LIF: 
LINJ_18_1090(PKAC1) LINJ_35_4010 LINJ_35_4060
LDO: 
LDBPK_181090 LDBPK_292140
LMI: 
LMXM_08_29_2020 LMXM_18_1080 LMXM_34_3960 LMXM_34_4010
LBZ: 
LBRM_18_1180 LBRM_29_1990 LBRM_34_3990
GLA: 
GL50803_11214 GL50803_14364
PTI: 
PHATRDRAFT_8773(MARK3) PHATRDRAFT_9413
TPS: 
THAPSDRAFT_261973 THAPSDRAFT_26536(SNF1) THAPSDRAFT_30963(PKA) THAPS_16501
PIF: 
PITG_02429 PITG_14707 PITG_20156
 » show all
Taxonomy
Reference
1  [PMID:11705384]
  Authors
Technikova-Dobrova Z, Sardanelli AM, Speranza F, Scacco S, Signorile A, Lorusso V, Papa S.
  Title
Cyclic adenosine monophosphate-dependent phosphorylation of mammalian mitochondrial proteins: enzyme and substrate characterization and functional role.
  Journal
Biochemistry. 40 (2001) 13941-7.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:11278927]
  Authors
Andersen MD, Shaffer J, Jennings PA, Adams JA.
  Title
Structural characterization of protein kinase A as a function of nucleotide binding. Hydrogen-deuterium exchange studies using matrix-assisted laser desorption ionization-time of flight mass spectrometry detection.
  Journal
J. Biol. Chem. 276 (2001) 14204-11.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:3036817]
  Authors
Johnson KE, Cameron S, Toda T, Wigler M, Zoller MJ.
  Title
Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae. Purification and characterization.
  Journal
J. Biol. Chem. 262 (1987) 8636-42.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
4  [PMID:10699496]
  Authors
Haq E, Sharma S, Khuller GK.
  Title
Purification and characterization of cAMP dependent protein kinase from Microsporum gypseum.
  Journal
Biochim. Biophys. Acta. 1474 (2000) 100-6.
  Organism
Microsporum gypseum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
142008-29-5
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