KEGG   ENZYME: 2.7.11.13Help
Entry
EC 2.7.11.13                Enzyme                                 
Name
protein kinase C;
calcium-dependent protein kinase C;
calcium-independent protein kinase C;
calcium/phospholipid dependent protein kinase;
cPKCalpha;
cPKCbeta;
cPKCgamma;
nPKCdelta;
nPKCepsilon;
nPKC;
nPKC;
PKC;
PKCalpha;
PKCbeta;
PKCgamma;
PKCdelta;
PKCepsilon;
PKCzeta;
Pkc1p;
protein kinase Cepsilon;
STK24
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (diacylglycerol-dependent)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
Orthology
K02677  
classical protein kinase C
K06068  
novel protein kinase C
K06069  
atypical protein kinase C
K06070  
protein kinase D
K06071  
protein kinase N
Genes
HSA: 
23683(PRKD3) 25865(PRKD2) 29941(PKN3) 5578(PRKCA) 5579(PRKCB) 5580(PRKCD) 5581(PRKCE) 5582(PRKCG) 5583(PRKCH) 5584(PRKCI) 5585(PKN1) 5586(PKN2) 5587(PRKD1) 5588(PRKCQ) 5590(PRKCZ)
PTR: 
450143(PRKCI) 450288(PRKCQ) 452834(PRKD1) 453993(PRKCB) 454832(PRKCA) 455785(PKN1) 456276(PRKCG) 456998(PKN2) 459158(PRKD3) 459203(PRKCE) 460442(PRKCD) 464773(PKN3) 468929(PRKD2) 743533(PRKCZ) 746068(PRKCH)
PPS: 
100967981(PRKCA) 100970296(PRKCB) 100972885(PKN1) 100974922(PRKCE) 100978487(PRKCD) 100979245(PRKCI) 100980423(PRKD3) 100986775(PRKD2) 100987713(PRKCZ) 100989627(PRKD1) 100990245(PRKCG) 100992814(PKN2) 100993271(PKN3) 100994611(PRKCH) 100995594(PRKCQ)
GGO: 
101124433(PRKCI) 101124828(PRKCA) 101127296 101127426(PRKCQ) 101129716(PKN2) 101130256(PRKD2) 101132383(PRKCH) 101132459(PKN3) 101133370(PRKCD) 101133595(PRKCE) 101135770(PKN1) 101139074(PRKCG) 101139890(PRKD1) 101150691 101152946(PRKD3)
PON: 
100173964(PRKCI) 100174126(PRKCZ) 100438192(PKN2) 100438207(PRKD3) 100438798 100440176 100440778(PRKCE) 100441363(PRKD1) 100443896(PRKCQ) 100450407(PRKCH) 100450739(PKN3) 100451563(PRKCG) 100452668(PRKCD)
MCC: 
574352(PRKCI) 693505 694656 701195(PRKCB) 704356(PRKCH) 709647(PRKD3) 710340 714533(PRKCE) 716736 716937(PRKD1) 717319(PKN3) 718412(PRKCA) 718834 720263(PRKCG) 722559(PRKCQ)
MMU: 
101540(Prkd2) 109333(Pkn2) 18750(Prkca) 18751(Prkcb) 18752(Prkcg) 18753(Prkcd) 18754(Prkce) 18755(Prkch) 18759(Prkci) 18760(Prkd1) 18761(Prkcq) 18762(Prkcz) 263803(Pkn3) 320795(Pkn1) 75292(Prkd3)
RNO: 
170538(Prkcd) 207122(Pkn2) 24680(Prkca) 24681(Prkcg) 25023(Prkcb) 25522(Prkcz) 292658(Prkd2) 29340(Prkce) 29355(Pkn1) 296619(Pkn3) 313834(Prkd3) 81749(Prkch) 84006(Prkci) 85420(Prkcq) 85421(Prkd1)
CFA: 
100855828 100856398 478013(PRKCQ) 478686(PRKCI) 479577(PRKCZ) 483036(PRKD3) 484316(PRKCG) 484427(PRKD2) 489968(PRKCB) 490174(PKN2) 490722(PRKCH) 490904(PRKCA) 491313(PKN3) 494005(PRKCD) 609091(PRKD1) 609934(PRKCE)
AML: 
FCA: 
101080543(PRKD1) 101081653(PKN2) 101082196(PRKCG) 101082413(PRKCH) 101086433(PRKCA) 101087000(PRKCI) 101087716(PRKCD) 101087851(PRKCZ) 101088970(PRKCB) 101093557(PKN3) 101097547(PKN1) 101100101(PRKD2) 101100730(PRKCQ) 101100883(PRKD3) 101100958(PRKCE)
BTA: 
282001(PRKCA) 282002(PRKCG) 282325(PRKCB) 286877(PRKCZ) 505353(PKN3) 505708(PRKCD) 505901(PRKCQ) 507041(PRKCE) 509080(PKN1) 518542(PRKCH) 519754(PKN2) 528478(PRKCI) 533270(PRKD1) 538447(PRKD3) 782793(PRKD2)
SSC: 
100152637(PKC) 100154766(PKN2) 100174945(PRKCI) 100517036(PRKD2) 100518074 100519640(PKN3) 100522792 100523181(PRKD3) 100524932 100533200(PRKCZ) 100621326 397184(PRKCA)
ECB: 
100051333 100051560(PRKCH) 100052266(PKN2) 100053394(PRKCE) 100054187(PRKD3) 100054964(PRKD1) 100062549(PRKCG) 100063318(PRKCA) 100063737(PRKCI) 100064240 100066882(PKN3) 100070207(PRKCQ)
MDO: 
100010321(PRKCQ) 100010646 100011137(PRKD3) 100013311(PKN3) 100013333(PRKD1) 100013346 100020001 100020306 100024674 100026472 100027190(PRKCH) 100027775 100030202 100030722(PRKCD) 100032210(PRKCE)
SHR: 
100913337(PRKCA) 100913910(PRKD3) 100916377 100918841(PRKD1) 100919789(PRKCQ) 100921310(PKN1) 100921656(PRKCE) 100924022(PRKCB) 100924608(PKN3) 100925245(PRKCD) 100925605(PRKCI) 100929232(PKN2) 100934220(PRKCH) 100935225(PRKCG)
OAA: 
100075015(PKN3) 100075522 100077834(PRKCI) 100077901(PRKD3) 100079107 100079662 100082317(PRKD1) 100085025(PRKCQ) 100085789 100086580 100089779
GGA: 
415905(PRKCD) 416567(PRKCB) 417209(PKN3) 417430(PRKCA) 419399(PRKCZ) 421409(PRKCE) 421478(PRKD3) 423302(PRKD1) 423518(PRKCH) 424519(PKN2) 424991(PRKCI) 776459(PRKCQ)
MGP: 
100538756 100541727 100541931 100543370(PRKD1) 100543758(PRKCE) 100545425(PRKCH) 100546134 100546425 100547068(PKN2) 100547919 100550758
TGU: 
100219195(PRKCA) 100220987(PRKCH) 100221030(PRKD1) 100221527(PRKD3) 100224539(PRKCZ) 100227442(PRKCB) 100227906(PRKCI) 100230164(PKN2) 100230589(PRKCE) 100230711 100231125 100232581(PRKCQ)
ACS: 
100553700 100555511(prkch) 100555795(pkn2) 100558587(prkd1) 100559682 100563064(prkd3) 100566151 100567346(prkce) 100567847
XLA: 
399287(prkci) 404226(prkcd-a) 404227(prkcd-b) 444221(prkch) 447031(prkca) 447531(prkd1)
XTR: 
100038043(prkcb) 100038268(prkcq) 100101769(prkcz) 100135720(prkce) 100145241 100151704(prkd1) 100151731(prkch) 100496779 503517(prkci) 733756(prkcd) 780209(prkca)
DRE: 
100003514 100005075(prkcea) 100006675(prkcba) 100144561(prkcha) 100150844 117507(prkci) 323182(pkn3) 334571(prkcda) 393953(prkcbb) 497384(prkca) 555521(prkcq) 555737(prkcz) 557123(prkd1) 557337(prkd3) 560840 567134(pkn2) 571965
TRU: 
101062863 101064815 101065234 101067313 101068230 101069685 101069776 101070414 101071034 101072284 101072784 101078899 101079823 101080003
OLA: 
101157143 101158798 101158986 101159746 101160371 101161464 101164401 101164700 101164921 101165085 101165764 101167165 101168507 101172355 101174016
BFO: 
BRAFLDRAFT_124449 BRAFLDRAFT_173713 BRAFLDRAFT_210451 BRAFLDRAFT_275928 BRAFLDRAFT_57451 BRAFLDRAFT_59608 BRAFLDRAFT_59849
CIN: 
100180505(prkd1) 100180863 100186768(prkca)
SPU: 
100890668 575375 581257(PRKCI) 582022 582463
DME: 
Dmel_CG1954(Pkc98E) Dmel_CG2049(Pkn) Dmel_CG42349(Pkcdelta) Dmel_CG42783(aPKC) Dmel_CG6518(inaC) Dmel_CG6622(Pkc53E) Dmel_CG7125(PKD)
DPO: 
Dpse_GA10200 Dpse_GA10861 Dpse_GA15149 Dpse_GA19657 Dpse_GA19732 Dpse_GA24329 Dpse_GA24330 Dpse_GA27185
DAN: 
Dana_GF11423 Dana_GF11424 Dana_GF12632 Dana_GF13089 Dana_GF16270 Dana_GF18121 Dana_GF19394
DER: 
Dere_GG10569 Dere_GG11634 Dere_GG16497 Dere_GG17719 Dere_GG20644 Dere_GG20645 Dere_GG22380
DPE: 
Dper_GL11569 Dper_GL11571 Dper_GL16898 Dper_GL16900 Dper_GL23202 Dper_GL24249 Dper_GL25244
DSE: 
Dsec_GM12756 Dsec_GM15303 Dsec_GM20164 Dsec_GM20615 Dsec_GM21738 Dsec_GM21740
DSI: 
Dsim_GD10089 Dsim_GD11232 Dsim_GD11233 Dsim_GD20181 Dsim_GD21405 Dsim_GD25642
DWI: 
Dwil_GK11499 Dwil_GK16493 Dwil_GK17968 Dwil_GK17969 Dwil_GK21803 Dwil_GK22030 Dwil_GK22032 Dwil_GK22565
DYA: 
Dyak_GE11630 Dyak_GE11833 Dyak_GE12269 Dyak_GE17008 Dyak_GE22423 Dyak_GE23824 Dyak_GE25210
DGR: 
Dgri_GH17566 Dgri_GH18675 Dgri_GH19234 Dgri_GH20027 Dgri_GH20028 Dgri_GH20802 Dgri_GH22649 Dgri_GH22650
DMO: 
Dmoj_GI19206 Dmoj_GI20886 Dmoj_GI21162 Dmoj_GI21163 Dmoj_GI21641 Dmoj_GI24186 Dmoj_GI24268
DVI: 
Dvir_GJ10533 Dvir_GJ10840 Dvir_GJ16879 Dvir_GJ20273 Dvir_GJ20275 Dvir_GJ20621 Dvir_GJ21015 Dvir_GJ21016
AGA: 
AgaP_AGAP000070 AgaP_AGAP000418 AgaP_AGAP002748 AgaP_AGAP007587 AgaP_AGAP012252
AAG: 
AaeL_AAEL000810 AaeL_AAEL001108 AaeL_AAEL001549 AaeL_AAEL002885 AaeL_AAEL002892
CQU: 
CpipJ_CPIJ000227 CpipJ_CPIJ005701 CpipJ_CPIJ006704 CpipJ_CPIJ013835 CpipJ_CPIJ020037
AME: 
406106(Pkc) 411270(Pkcdelta) 412608(PKD) 413834(aPKC) 725923(Pkn)
NVI: 
100114311(NV16050) 100114442(NV14764) 100116629(NV14251) 100117158(NV12122) 100117679(NV14702)
TCA: 
658064 659637 663080 663551 663691
API: 
100160218 100160542 100160881 100161464 100163880 100166226 100166344(PRKCI)
PHU: 
Phum_PHUM238860 Phum_PHUM513980 Phum_PHUM528520 Phum_PHUM529700 Phum_PHUM537470 Phum_PHUM544690
ISC: 
IscW_ISCW004410 IscW_ISCW011060 IscW_ISCW020000 IscW_ISCW023594
CEL: 
CELE_B0545.1(tpa-1) CELE_E01H11.1(pkc-2) CELE_F09E5.1(pkc-3) CELE_W09C5.5(dkf-1)
CBR: 
CBG01645(Cbr-tpa-1) CBG02381(Cbr-pkc-3) CBG16150(Cbr-pkc-2) CBG17105 CBG17230 CBG19775 CBG23354(Cbr-pkc-1)
BMY: 
Bm1_03335 Bm1_26110 Bm1_26205 Bm1_31105 Bm1_50250 Bm1_52195
TSP: 
Tsp_04112 Tsp_06981 Tsp_09284 Tsp_11610 Tsp_11978 Tsp_12157
SMM: 
Smp_096310(aPKC) Smp_131700 Smp_155950 Smp_160760 Smp_176360
NVE: 
NEMVE_v1g104852 NEMVE_v1g202173 NEMVE_v1g245970 NEMVE_v1g93932 NEMVE_v1g98367
HMG: 
100197654 100198141 100199454 100201868 100208590 100210930
TAD: 
TRIADDRAFT_20496 TRIADDRAFT_20881 TRIADDRAFT_30067 TRIADDRAFT_30089 TRIADDRAFT_57608
AQU: 
100631608 100633255 100633428(Prkce) 100633579 100633652 100636609
SCE: 
YBL105C(PKC1)
AGO: 
AGOS_ACR191C
ERC: 
Ecym_4652
KLA: 
KLLA0E06447g
LTH: 
KLTH0C05478g
PPA: 
PAS_chr2-1_0124
VPO: 
Kpol_520p17
ZRO: 
ZYRO0F13310g
CGR: 
CAGL0M09361g
NCS: 
NCAS_0E03010(NCAS0E03010)
NDI: 
NDAI_0E04610(NDAI0E04610)
TPF: 
TPHA_0B01520(TPHA0B01520)
TBL: 
TBLA_0I00910(TBLA0I00910)
TDL: 
TDEL_0C03050(TDEL0C03050)
KAF: 
KAFR_0G01080(KAFR0G01080)
DHA: 
DEHA2G13904g
PIC: 
PICST_81215
PGU: 
PGUG_04383
LEL: 
LELG_02660
CAL: 
CaO19.13322(PKC1) CaO19.5901(PKC1)
CTP: 
CTRG_02299
CDU: 
CD36_84410(PKC1)
COT: 
CORT_0C03120
YLI: 
YALI0F09746g
CLU: 
CLUG_03890
NCR: 
NCU06544
SMP: 
SMAC_04666
PAN: 
PODANS72p033
TTT: 
THITE_2114319
MTM: 
MYCTH_98099
MGR: 
MGG_08689
FGR: 
FG09660.1
NHE: 
NECHADRAFT_103351
VAL: 
VDBG_03477
SSL: 
SS1G_14026
BFU: 
BC1G_07478
ANI: 
AN0106.2
NFI: 
NFIA_075320
AFM: 
AFUA_5G11970
AOR: 
AOR_1_552094(AO090120000316)
ANG: 
ANI_1_290164(An18g02400)
AFV: 
AFLA_092990
ACT: 
ACLA_014990
PCS: 
Pc21g07090
CIM: 
CIMG_09206
CPW: 
CPC735_016210
PBL: 
PAAG_02441
URE: 
UREG_05250
ABE: 
ARB_04376
TVE: 
TRV_03166
AJE: 
HCAG_02636
PNO: 
SNOG_07073
PTE: 
PTT_19155
ZTR: 
MYCGRDRAFT_87605(Pkc1b)
TML: 
GSTUM_00001395001
SPO: 
SPBC12D12.04c(pck2)
CNE: 
CNC03300
CNB: 
CNBC3910
CGI: 
CGB_C5150C
PPL: 
POSPLDRAFT_126101
LBC: 
LACBIDRAFT_309070(LbPKC1)
MPR: 
MPER_01651 MPER_10185
CCI: 
CC1G_07190
SCM: 
SCHCODRAFT_233381
MGL: 
MGL_2756 MGL_2757
PGR: 
PGTG_12641
NCE: 
NCER_101503
MBR: 
MONBRDRAFT_10752 MONBRDRAFT_20766 MONBRDRAFT_21555
 » show all
Taxonomy
Reference
1  [PMID:2194521]
  Authors
Jaken S.
  Title
Protein kinase C and tumor promoters.
  Journal
Curr. Opin. Cell. Biol. 2 (1990) 192-7.
Reference
2  [PMID:10675318]
  Authors
Parekh DB, Ziegler W, Parker PJ.
  Title
Multiple pathways control protein kinase C phosphorylation.
  Journal
EMBO. J. 19 (2000) 496-503.
  Organism
mammalian
Reference
3  [PMID:10604989]
  Authors
Valledor AF, Xaus J, Comalada M, Soler C, Celada A.
  Title
Protein kinase C epsilon is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.
  Journal
J. Immunol. 164 (2000) 29-37.
  Organism
Mus musculus [GN:mmu]
Reference
4  [PMID:9480876]
  Authors
Lendenfeld T, Kubicek CP.
  Title
Characterization and properties of protein kinase C from the filamentous fungus Trichoderma reesei.
  Journal
Biochem. J. 330 ( Pt 2) (1998) 689-94.
  Organism
Trichoderma reesei
Reference
5  [PMID:9530509]
  Authors
Brooks SP, Storey KB.
  Title
Protein kinase C from rainbow trout brain: identification and characterization of three isozymes.
  Journal
Biochem. Mol. Biol. Int. 44 (1998) 259-67.
  Organism
Oncorhynchus mykiss
Other DBs
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